Publications by authors named "Heyer C"
Article Synopsis
- Cardiac pressure overload can lead to problems for patients with congenital heart defects, and using stem cell-derived heart cells might help improve heart function alongside surgery.
- Researchers successfully implanted human stem cell-derived heart cells into the hearts of rhesus macaques facing induced pressure overload, achieving good integration with the existing heart tissue.
- Although some monkeys experienced episodes of ventricular tachycardia after the cell transplant, these events generally resolved within a few weeks, indicating a need for monitoring but also promising potential for this treatment approach.
Pathogenic variants in the ryanodine receptor 1 () gene are causative for a wide spectrum of muscular phenotypes, ranging from malignant hyperthermia over mild, non-progressive to severe congenital myopathy. Both autosomal dominant and recessive inheritance can occur, with the more severe forms usually showing recessive inheritance. However, genotype-phenotype correlations are complicated due to the large size of the gene and heterogeneous phenotypes.
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