Objective: Nrf2/ARE signaling pathway is reported to alleviate sleep anxiety in patients with sleep disorders. This study aimed at exploring the effect of escitalopram (ESC) on sleep anxiety in patients with cerebral small vessel disease (CSVD) and sleep disorder and its correlation with the Nrf2/ARE signaling pathway.
Methods: In the present study, we enrolled 80 CSVD patients (disease group) and 40 healthy patients (control group) in our hospital.