Harnessing glycofluoroforms for impedimetric biosensing.

Glycans play a major role in biological cell-cell recognition and signal transduction but have found limited application in biosensors due to glycan/lectin promiscuity; multiple proteins are capable of binding to the same native glycan. Here, site-specific fluorination is used to introduce protein-glycan selectivity, and this is coupled with an electrochemical detection method to generate a novel biosensor platform. 3F-lacto--biose glycofluoroform is installed onto polymer tethers, which are subsequently immobilised onto gold screen printed electrodes, providing a non-fouling surface.

Strength deficits in lower limb prosthesis users: A scoping review.

Background: Strength deficits may play a central role in the severity of balance, mobility, and endurance impairments in lower limb prosthesis users. A body of literature detailing the scope and specifics of muscle weakness in lower limb prosthesis users is emerging, but has yet to be summarized. A synopsis of strength deficits, and their impact on functional abilities in lower limb prosthesis users, may inform rehabilitation and research needs.

Autologous neurosensory retinal flap for closure of refractory macular hole in a patient with macular telangiectasia.

Purpose: This study explores autologous neurosensory autograph for a patient with a chronic full-thickness macular hole (FTMH) and idiopathic macular telangiectasia type 2 (IMT2).

Observations: The patient had a chronic 1355 μm FTMH and best corrected visual acuity (BCVA) of 2 logMAR units after two unsuccessful attempts to close the macular hole. Following a 25-gauge vitrectomy, a 2-disc diameter neurosensory autograft from the supertemporal retina was mobilized and secured with perfluoro-N-octane (PFO) tamponade.

Higher-Order Fermi-Liquid Corrections for an Anderson Impurity Away from Half Filling.

We study the higher-order Fermi-liquid relations of Kondo systems for arbitrary impurity-electron fillings, extending the many-body quantum theoretical approach of Yamada and Yosida. It includes, partly, a microscopic clarification of the related achievements based on Nozières' phenomenological description: Filippone, Moca, von Delft, and Mora [Phys. Rev.

Analytic Flow Equations for the Fermi Liquid Parameters of the Anderson Impurity Model.

The low temperature behavior of a Fermi liquid can be described in terms of quasiparticle excitations that are in 1-1 correspondence with those of the noninteracting system. Because of adiabatic continuity, the Landau parameters, which describe the interactions between the quasiparticles, must evolve continuously as the interactions are turned on and be described by a set of flow equations. For strongly correlated electron systems it is not possible to follow this flow in perturbation theory when the interactions become strong.

Mouthguard use and dental injury in sport: a questionnaire study of national school children in the west of Ireland.

Statement Of The Problem: The risk of children getting dental injuries during sport can be minimised by using a mouthguard. Within Ireland, information on mouthguard use and policy is limited. The extent of dental trauma experienced by children during sport is also unclear.

Full counting statistics for orbital-degenerate impurity Anderson model with Hund's rule exchange coupling.

We study nonequilibrium current fluctuations through a quantum dot, which includes a ferromagnetic Hund's rule coupling J, in the low-energy Fermi liquid regime using the renormalized perturbation theory. The resulting cumulant for the current distribution in the particle-hole symmetric case shows that spin-triplet and spin-singlet pairs of quasiparticles are formed in the current due to the Hund's rule coupling, and these pairs enhance the current fluctuations. In the fully screened higher-spin Kondo limit, the Fano factor takes a value F(b)=(9M+6)/(5M+4) determined by the orbital degeneracy M.

Convergence of energy scales on the approach to a local quantum critical point.

We find the emergence of strong correlations and universality on the approach to the quantum critical points of a two-impurity Anderson model. The two impurities are coupled by an interimpurity exchange interaction J and direct interaction U{12} and are hybridized with separate conduction channels. The low energy behavior is described in terms of renormalized parameters.

Cleft-affected children in Mayo: 1999-2007.

The aims of this study were to investigate the medical and dental care of children born in Mayo with cleft lip and/or palate in the period 1999-2007. Thirteen subjects were identified--nine males and four females. Galway was the main locus for cleft surgical referral and care, with 10 subjects receiving treatment by the same surgeon.

A new renormalization group approach for systems with strong electron correlation.

The anomalous low energy behaviour observed in metals with strong electron correlation, such as in the heavy fermion materials, is believed to arise from the scattering of the itinerant electrons with low energy spin fluctuations. In systems with magnetic impurities this scattering leads to the Kondo effect and a low energy renormalized energy scale, the Kondo temperature T(K). It has been generally assumed that these low energy scales can only be accessed by a non-perturbative approach due to the strength of the local inter-electron interactions.

Numerical renormalization group study of probability distributions for local fluctuations in the Anderson-Holstein and Holstein-Hubbard models.

We show that information on the probability density of local fluctuations can be obtained from a numerical renormalization group calculation of a reduced density matrix. We apply this approach to the Anderson-Holstein impurity model to calculate the ground state probability density ρ(x) for the displacement x of the local oscillator. From this density we can deduce an effective local potential for the oscillator and compare its form with that obtained from a semiclassical approximation as a function of the coupling strength.

Axenfeld-Rieger syndrome (ARS): A review and case report.

Axenfeld-Rieger syndrome (ARS) is a rare, autosomal dominant condition characterized by ocular, craniofacial, dental, and periumbilical abnormalities. Relatively little information exists on this syndrome within the dental literature despite the fact that midface hypoplasia and maxillary hypodontia are classical presenting features of this syndrome. This is a case report of a 7-year-old Caucasian female with ARS who presented with significant ocular and dental anomalies.

Quantification of the bioavailability of riboflavin from foods by use of stable-isotope labels and kinetic modeling.

Background: Discrepancies have been reported between estimates of the prevalence of riboflavin deficiency based on intakes of riboflavin and estimates based on measures of riboflavin status. One reason for this may be an overestimate of the bioavailability of riboflavin from foods, about which relatively little is known.

Objective: We aimed to quantify the bioavailability of riboflavin from milk and spinach by using stable-isotope labels and a urinary monitoring technique and by a plasma appearance method based on kinetic modeling.

Polaronic quasiparticles in a strongly correlated electron band.

We show that a strongly renormalized band of polaronic quasiparticle excitations is induced at the Fermi level of an interacting many-electron system on increasing the coupling of the electrons to local phonons. We give results for the local density of states at zero temperature both for the electrons and phonons. The polaronic quasiparticles satisfy Luttinger's theorem for all regimes considered, and their dispersion shows a kink similar to that observed experimentally in copper oxides.

Severe mesh complications following intravaginal slingplasty.

Objective: Synthetic meshes are increasingly used in the management of stress urinary incontinence and pelvic organ prolapse. This report describes severe complications following anterior and/or posterior intravaginal slingplasties employing a multifilament polypropylene mesh.

Methods: We describe the symptoms, findings, subsequent management, and outcome of 19 consecutive women who have been referred with complications following anterior (n = 11) and/or posterior intravaginal slingplasty (n = 13) employing the multifilament polypropylene tape.

Central responsiveness to a ghrelin mimetic (GHRP-6) is rapidly altered by acute changes in nutritional status in rats.

The hypothalamus appears to be more responsive to ghrelin and growth hormone secretagogues (GHS) in fasting, as reflected by a two- to three-fold increase in the number of cells detected that express Fos protein in the arcuate nucleus, in 48-h fasted rats compared to fed controls. Moreover, this increased hypothalamic responsiveness to GHS in fasting is regulated by the central action of exogenous leptin and insulin, although it is unknown whether these hormones mediate the changes in hypothalamic responsiveness to GHS associated with the fasting/fed state. In the present study, we show that refeeding with normal rat chow for only 2 h at the end of a 48-h fast reversed the potentiation of the Fos response to GHRP-6 observed in fasted rats.

Pathological implications of iNOS expression in central white matter: an ex vivo study of optic nerves from rats with experimental allergic encephalomyelitis.

Excessive nitric oxide (NO) production from the inducible isoform of nitric oxide synthase (iNOS) has been invoked as a causative factor in many neurodegenerative disorders, including multiple sclerosis. This hypothesis has been supported by in vitro studies showing that glial iNOS expression results in toxic NO concentrations (near 1 microm). To investigate the relevance of such findings, experiments were carried out ex vivo on optic nerves from rats with exacerbated experimental allergic encephalomyelitis, a model of multiple sclerosis.

Glucocorticoid-dependent stimulation of adiposity and appetite by a ghrelin mimetic in the rat.

Objective: Chronic administration of GH secretagogues (GHSs) induces a state of positive energy balance in rodents by a GH-independent mechanism. Here we sought to determine to what extent the GHS effects to increase food intake and increase fat accumulation are glucocorticoid-dependent.

Design: The effects of twice-daily s.

Simplified colposuspension: a 15-year follow-up.

Aim: Retrospective analysis of long-term results of a simplified 'Burch type' colposuspension.

Methods: A retrospective chart review, with follow-up through postal questionnaires sent in September 2000, of all 374 patients who had a simplified colposuspension between 1985 and 1998, with additional total abdominal hysterectomy in 103 patients. Outcome measures were patient satisfaction, complications and recovery.

Intracerebroventricular injection of apelin-13 reduces food intake in the rat.

Apelin is a peptide recently identified as a ligand for the APJ receptor, a receptor located in tissues such as the small intestine and in the hypothalamus. Apelin has been detected in adipose tissue, gastrointestinal tract, heart and stomach. Recent reports suggest a role for apelin in the regulation of blood pressure and the control of body fluid homeostasis.

The rat arcuate nucleus integrates peripheral signals provided by leptin, insulin, and a ghrelin mimetic.

The hypothalamic circuits controlling food intake and body weight receive and integrate information from circulating satiety signals such as leptin and insulin and also from ghrelin, the only known circulating hormone that stimulates appetite following systemic injection. Activation of arcuate neurons by ghrelin and ghrelin mimetics (the growth hormone secretagogues) is augmented in 48-h-fasted rats compared with fed rats, as reflected by a greater number of cells expressing Fos protein in response to administration of the same maximally effective dose. Here we sought to determine whether this increased responsiveness in fasting might reflect or be influenced by low levels of circulating satiety factors such as leptin or insulin.

Gap formation and soft phonon mode in the Holstein model.

We investigate electron-phonon coupling in many-electron systems using the dynamical mean-field theory in combination with the numerical renormalization group. This nonperturbative method reveals significant precursor effects to the gap formation at intermediate coupling strengths. The emergence of a soft phonon mode and very strong lattice fluctuations can be understood in terms of Kondo-like physics due to the development of a double-well structure in the effective potential for the ions.

Growth hormone (GH) and GH-releasing peptide-6 increase brain insulin-like growth factor-I expression and activate intracellular signaling pathways involved in neuroprotection.

Beneficial effects of GH on memory, mental alertness, and motivation have been documented. Many actions of GH are mediated through IGF-I; hence, we investigated whether systemic administration of GH or GH-releasing peptide (GHRP)-6 modulates the brain IGF system. Treatment of adult male rats with GHRP-6 or GH for 1 wk significantly increased IGF-I mRNA levels in the hypothalamus, cerebellum, and hippocampus, with no effect in cerebral cortex.

Transfusion rate associated with hysterectomy for benign disease.

The transfusion rate associated with hysterectomy for benign disease is an indirect indicator of haemorrhage. It is used in quality assurance activities and is one measure of standard of care. This retrospective study was conducted to determine the transfusion rate for these operations in a tertiary referral hospital.