Effects of Hormone Replacement Therapy on Low Bone Mineral Density in Adolescents and Young Women with Hypogonadism: Comparison of Oral and Transdermal 17 Beta-Estradiol Administration.

Study Objective: To evaluate the effects of physiological dose 17 beta-estradiol (E) replacement on low bone mineral density (BMD) and compare the results of oral and transdermal (TD) E administration in adolescents and young women with hypogonadism DESIGN, SETTING, AND PARTICIPANTS: We retrospectively reviewed the medical records of patients aged 15 to 24 years who were diagnosed with hypogonadism, who had begun receiving oral or TD E replacement, and whose initial dual-energy X-ray absorptiometry scan detected a lumbar spine BMD Z-score of -1 or lower between 2014 and 2018. The patients were divided into 2 groups according to the E route of administration as those who received 2 mg orally (Group 1) and 0.1 mg TD (Group 2).