Publications by authors named "Heung-Soo Beak"
Article Synopsis
- An ubiquinone derivative called pseudoalteromone A was isolated from marine species APmarine002 and ROA-050 and shown to have anti-melanogenesis effects.
- Treatment with pseudoalteromone A significantly reduced melanin production and tyrosinase activity in various melanocyte cell lines, indicating its potential for skin-whitening.
- Further analysis using a 3D pigmented skin model confirmed that pseudoalteromone A inhibits melanogenic gene expression, leading to its anti-melanogenic properties.
AP736 itself is a novel skin whitening agent reported to exhibit anti-melanogenic and tyrosinase inhibitory activity. However, formulating a topical product has been difficult because AP736 is insoluble in water as well as in many oils. In this study, we aimed to develop a new topical delivery system in which AP736 is not only physically stable, but also suitably delivered to the skin.
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- Recent research has focused on developing effective skin-lightening compounds, particularly studying AP736, a new compound derived from adamantyl benzylbenzamide, in melanoma cells.
- AP736 was found to reduce melanin production by inhibiting key enzymatic activities involved in melanogenesis, specifically through the GSK3β signaling pathway, rather than directly blocking tyrosinase activity.
- The compound led to inactivation of GSK3β, which contributed to the downregulation of tyrosinase expression, highlighting its potential as a dermatological depigmenting agent.
AP736 was identified as an antimelanogenic drug that can be used for the prevention of melasma, freckles, and dark spots in skin by acting as a suppressor of melanin synthesis and tyrosinase expression. Since macrophage-mediated inflammatory responses are critical for skin health, here we investigated the potential anti-inflammatory activity of AP736. The effects of AP736 on various inflammatory events such as nitric oxide (NO)/prostaglandin (PG) E2 production, inflammatory gene expression, phagocytic uptake, and morphological changes were examined in RAW264.
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