Publications by authors named "Heung Sik Kim"

Electroconvulsive therapy (ECT) is a therapeutic intervention that induces generalized seizures under general anesthesia. This case report compares the efficacy of dexmedetomidine (DEX) and nitrous oxide (N2O) to that of propofol during ECT procedures. A 33-year-old woman with a 15-year history of schizophrenia and recurrent psychotic episodes underwent ECT.

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Layered honeycomb cobaltates are predicted as promising for realizing the Kitaev quantum spin liquid, a many-body quantum entangled ground state characterized by fractional excitations. However, they exhibit antiferromagnetic ordering at low temperatures, hindering the expected quantum state. We demonstrate that controlling the trigonal distortion of CoO octahedra is crucial to suppress antiferromagnetic order through enhancing frustration in layered honeycomb cobaltates.

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Kagome lattice has been actively studied for the possible realization of frustration-induced two-dimensional flat bands and a number of correlation-induced phases. Currently, the search for kagome systems with a nearly dispersionless flat band close to the Fermi level is ongoing. Here, by combining theoretical and experimental tools, we present ScMnAlSi as a novel realization of correlation-induced almost-flat bands in the kagome lattice in the vicinity of the Fermi level.

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Layered honeycomb magnets with strong atomic spin-orbit coupling at transition metal sites have been intensively studied for the search of Kitaev magnetism and the resulting non-Abelian braiding statistics. α-RuCl3 has been the most promising candidate, and there have been several reports on the realization of sibling compounds α-RuBr3 and α-RuI3 with the same crystal structure. Here, we investigate correlated electronic structures of α-RuCl3 and α-RuI3 by employing first-principles dynamical mean-field theory.

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Hypophosphatasia (HPP) is a rare condition characterized by abnormal bone mineralization. The manifestations of HPP vary from no symptoms to intrauterine fetal death; short stature is another indication of HPP. A 3 ½-year-old boy presented with short stature, transient hypercalcemia, and mild gait disturbance without definite bony deformity.

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Background/aims: We evaluated the feasibility and long-term efficacy of the combination of cytarabine, idarubicin, and all-trans retinoic acid (ATRA) for treating patients with newly diagnosed acute promyelocytic leukemia (APL).

Methods: We included 87 patients with newly diagnosed acute myeloid leukemia and a t(15;17) or promyelocytic leukemia/retinoic acid receptor alpha (PML-RARα) mutation. Patients received 12 mg/m2/day idarubicin intravenously for 3 days and 100 mg/m2/day cytarabine for 7 days, plus 45 mg/m2/day ATRA.

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The realization of Kitaev's honeycomb magnetic model in real materials has become one of the most pursued topics in condensed matter physics and materials science. If found, it is expected to host exotic quantum phases of matter and offers potential realizations of fault-tolerant quantum computations. Over the past years, much effort has been made on 4- or 5-heavy transition metal compounds because of their intrinsic strong spin-orbit coupling.

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Finding new materials with antiferromagnetic (AFM) Kitaev interaction is an urgent issue for quantum magnetism research. We conclude that NaCoSbOand NaCoTeOare new honeycomb cobalt-based systems with AFM Kitaev interaction by carrying out inelastic neutron scattering experiments and subsequent analysis. The spin-orbit excitons observed at 20-28 meV in both compounds strongly support the idea that Coions of both compounds have a spin-orbital entangled= 1/2 state.

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Article Synopsis
  • The study addressed the challenges of diagnosing inherited platelet function disorders (IPFDs) in Korea due to lack of available testing methods.
  • Conducted by the Korean Pediatric Hematology Oncology Group, researchers used next-generation sequencing (NGS) to identify genetic variants in patients suspected of having IPFDs from March 2017 to December 2020.
  • Among 11 patients, 10 were diagnosed with Glanzmann thrombasthenia (GT), revealing both known and novel genetic variants, while one patient had platelet type bleeding disorder 18 with newly identified variants.
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Acute myeloid leukemia (AML) is the second most common pediatric leukemia, with a survival rate of 70%. In this retrospective study, we evaluated the treatment outcomes of pediatric AML among 144 patients diagnosed between 2000 and 2013. After induction, 80.

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Background: Hodgkin's lymphoma (HL) constitutes 10%-20% of all malignant lymphomas and has a high cure rate (5-year survival, around 90%). Recently, interest has increased concerning preventing secondary complications (secondary cancer, endocrine disorders) in long-term survivors. We aimed to study the epidemiologic features and therapeutic outcomes of HL in children, adolescents, and young adults in Korea.

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Backgruound: Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe, life-threatening inflammatory condition if untreated. We aimed to investigate the etiologies, outcomes, and risk factors for death in children and adults with HLH.

Methods: The medical records of patients who met the HLH criteria of two regional university hospitals in Korea between January 2001 and December 2019 were retrospectively investigated.

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Recent experimental findings of two dimensional ferromagnetism in Fe3GeTe2, whose critical temperature can reach room temperature by gating, has attracted great research interest. Here we performed elaborate ab initio studies using density functional theory, dynamical mean-field theory and magnetic force response theory. In contrast to the conventional wisdom, it is unambiguously shown that Fe3GeTe2 is not ferromagnetic but is antiferromagnetic, carrying zero net moment in its stoichiometric phase.

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Article Synopsis
  • Oral propranolol is the primary treatment for infantile hemangiomas (IH), and this study aimed to identify key cytokines affecting IH biology and indicators of regression after treatment.
  • Out of 49 patients under 1 year old with IH, 33 completed a year of propranolol therapy, showing a decrease in certain cytokines (MMP-2, bFGF, VEGF-α, MCP-1) that correlated with the lesions regressing.
  • The research suggests that monitoring cytokine levels, especially bFGF and VEGF before treatment, could be useful in predicting how well a patient will respond to propranolol.
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Background: For children and adolescents with cancer, going back to school is a key milestone in returning to "normal life."

Purpose: To identify the support vital for a successful transition, we evaluated the parents' needs and the challenges they face when their children return to school.

Methods: This multi-institutional study was conducted by the Korean Society of Pediatric Hematology and Oncology.

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  • Transition metal phosphorous trichalcogenides, denoted as MPX_{3}, are gaining attention for their potential Mott transitions in two-dimensional structures, particularly with M=Mn and Ni.
  • The study employs advanced calculations to examine the electronic properties of these compounds under external pressure, focusing on how MnPS_{3} experiences significant structural changes while NiPS_{3} remains stable.
  • The differences in lattice behavior are attributed to the orbital types (t_{2g} for Mn and e_{g} for Ni), with the findings suggesting that NiPS_{3} and NiPSe_{3} may enable ultrafast resistivity switching due to their unique electronic properties.
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Background: Pilocytic astrocytoma (PA) is a brain tumor that is relatively more common in children and young adults.

Methods: We retrospectively reviewed the medical records of patients with PA treated at a single center between 1988 and 2018.

Results: We included 31 subjects with PA.

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Article Synopsis
  • - We studied superlattices made of Ir and Ni, finding that electrons completely transfer from Ir to Ni at their interface, causing significant structural and electronic changes.
  • - Through experiments and calculations, we discovered that a strong crystal field splitting at the interface plays a bigger role than expected, enhancing spin configurations on both Ir and Ni sites.
  • - This research highlights how charge transfer at interfaces can influence various physical properties, paving the way for new studies on quantum states in oxide superlattices.
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Idiopathic infantile hypercalcemia is characterized by hypercalcemia, dehydration, vomiting, and failure to thrive, and it is due to mutations in 24-hydroxylase (CYP24A1). Recently, mutations in sodium-phosphate cotransporter (SLC34A1) expressed in the kidney were discovered as an additional cause of idiopathic infantile hypercalcemia. This report describes a female infant admitted for evaluation of nephrocalcinosis.

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Objectives: We aimed to evaluate treatment outcomes of pediatric acute lymphoblastic leukemia (ALL) subgroups by risk-stratification, in the Yeungnam region of Korea.

Methods: We reviewed the courses of 409 newly diagnosed ALL patients from January 2004 to December 2013 in the Yeungnam region.

Results: All patients were classified into three risk groups: standard risk (SR, n=212), high risk (HR, n=153) and very high risk (VHR, n=44).

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