Interprofessional Education Week: the impact of active and passive learning activities on students' perceptions of interprofessional education.

Healthcare professions faculty at a private Midwestern university designed an Interprofessional Education (IPE) Week, consisting of 12 different interprofessional learning activities over the span of one week. The purpose of the study was to determine students' perceptions toward interprofessional healthcare, as measured by the Student Perceptions of Interprofessional Clinical Education-Revised (SPICE-R), one week before and one week after the events to determine if the type of learning activity - more passive, didactic-type events or active learning events - impacted outcomes. Of the over 400 students representing predominantly athletic training, nursing, occupational therapy, and physical therapy programs who attended IPE Week, a total of 190 health professions students completed the pre- and post-IPE Week SPICE-R.

Cytokine biomarkers associated with clinical cases of acute flaccid myelitis.

Acute flaccid myelitis (AFM) is a serious neurological illness first recognized in the United States in 2014, with subsequent outbreaks every two years. Following extensive etiologic testing by multiple laboratories of hundreds of specimens collected from patients diagnosed with AFM, no consistent cause of AFM has been identified. However, viruses, including enteroviruses, have been implicated through detection in non-sterile site specimens and antibody studies.

The Effect of Estradiol Administration on Muscle Mass Loss and Cachexia Progression in Female Mice.

Cancer cachexia is a multifactorial muscle wasting condition characterized by severe body weight and muscle mass loss which is secondary to chronic disease. The mechanistic examination of cachexia has predominately focused on the male phenotype and created significant gaps in understanding cachexia progression in the female. Female hypogonadism can accompany cancer cachexia and is characterized by reduced circulating 17ß-estradiol and uterine atrophy.

Interprofessional Healthcare Students' Perceptions of a Simulation-Based Learning Experience.

Academic healthcare programs are incorporating interprofessional education (IPE) into students' learning experiences in order to prepare students for optimal clinical practice. This paper describes a simulation-based learning experience (SBLE) designed to encourage students (n = 130) from six healthcare professions to learn more about interprofessional communication, roles and responsibilities of the healthcare team, and knowledge of interprofessional collaborative practice. Data analysis showed statistically significant differences in participants' perceptions of roles/responsibilities for collaborative practice (p = 0.

Antibodies to Enteroviruses in Cerebrospinal Fluid of Patients with Acute Flaccid Myelitis.

Acute flaccid myelitis (AFM) has caused motor paralysis in >560 children in the United States since 2014. The temporal association of enterovirus (EV) outbreaks with increases in AFM cases and reports of fever, respiratory, or gastrointestinal illness prior to AFM in >90% of cases suggest a role for infectious agents. Cerebrospinal fluid (CSF) from 14 AFM and 5 non-AFM patients with central nervous system (CNS) diseases in 2018 were investigated by viral-capture high-throughput sequencing (VirCapSeq-VERT system).

Standardizing the Bedside Report to Promote Nurse Accountability and Work Effectiveness.

Background: This study evaluated bedside reporting from the nurse's perspective regarding accountability, empowerment, work effectiveness, satisfaction, and communication. The aim was to examine the effects of an educational learning activity on bedside handoff reporting related to accountability and work effectiveness. The communication was used at change of shift between frontline nurses, with future interprofessional implementation.

Ovarian function's role during cancer cachexia progression in the female mouse.

Cachexia is a debilitating condition that occurs with chronic disease, including cancer; our research has shown that some regulation of cancer cachexia progression is affected by sex differences. The mouse is genetically predisposed to develop intestinal tumors; IL-6 signaling and hypogonadism are associated with cachexia severity in the male. This relationship in the female warrants further investigation, as we have shown that the ability of IL-6 to induce cachexia differs between the sexes.

Eccentric contraction-induced myofiber growth in tumor-bearing mice.

Cancer cachexia is characterized by the progressive loss of skeletal muscle mass. While mouse skeletal muscle's response to an acute bout of stimulated low-frequency concentric muscle contractions is disrupted by cachexia, gaps remain in our understanding of cachexia's effects on eccentric contraction-induced muscle growth. The purpose of this study was to determine whether repeated bouts of stimulated high-frequency eccentric muscle contractions [high-frequency electrical muscle stimulation (HFES)] could stimulate myofiber growth during cancer cachexia progression, and whether this training disrupted muscle signaling associated with wasting.

Sex differences in the relationship of IL-6 signaling to cancer cachexia progression.

A devastating aspect of cancer cachexia is severe loss of muscle and fat mass. Though cachexia occurs in both sexes, it is not well-defined in the female. The Apc(Min/+) mouse is genetically predisposed to develop intestinal tumors; circulating IL-6 is a critical regulator of cancer cachexia in the male Apc(Min/+) mouse.

The effect of radiation dose on mouse skeletal muscle remodeling.

Background: The purpose of this study was to determine the effect of two clinically relevant radiation doses on the susceptibility of mouse skeletal muscle to remodeling.

Materials And Methods: Alterations in muscle morphology and regulatory signaling were examined in tibialis anterior and gastrocnemius muscles after radiation doses that differed in total biological effective dose (BED). Female C57BL/6 (8-wk) mice were randomly assigned to non-irradiated control, four fractionated doses of 4 Gy (4x4 Gy; BED 37 Gy), or a single 16 Gy dose (16 Gy; BED 100 Gy).

The homoeobox gene SIX1 alters myosin heavy chain isoform expression in mouse skeletal muscle.

Aim: Six1 is necessary for the genesis of several tissues, but in adults, it is expressed primarily in skeletal muscle where its function is unclear. Overexpression of Six1 with a cofactor in skeletal muscle causes slow-to-fast fibre-type transition. We sought to characterize the effects of a physiologically relevant Six1 knockdown.

Inferolateral migration of hydrogel orbital implants in microphthalmia.

Purpose: Hydrogel spheres may be useful in treating orbital hypoplasia associated with congenital microphthalmia. The authors describe migration associated with the use of these devices.

Methods: The authors retrospectively reviewed 5 cases in which a hydrogel orbital expander (Osmed) was implanted to treat orbital hypoplasia in pediatric patients with congenital microphthalmia (with or without previous surgery).

Dermal-fat graft as a primary enucleation technique.

A retrospective study of 36 dermal-fat grafts was undertaken to determine the indications as a primary enucleation implant material. Twenty-two patients or 61% required a reoperation in a three-year follow-up period. Sixty-seven percent required secondary prosthetic revision.

Improved prosthetic motility following enucleation.

Enucleation is the beginning of a long-term relationship between the ophthalmologist and the patient to provide a comfortable, cosmetically acceptable, anophthalmic socket. The ideal socket should have a low risk of implant extrusion, normal volume, and normal motility of the prosthesis. Aspheric motility implants provide good motility, but pressure points between implant and prosthesis may lead to discomfort or extrusion.