MicroRNA-148a Controls Epidermal and Hair Follicle Stem/Progenitor Cells by Modulating the Activities of ROCK1 and ELF5.

Skin and hair development is regulated by complex programs of gene activation and silencing and microRNA-dependent modulation of gene expression to maintain normal skin and hair follicle development, homeostasis, and cycling. In this study, we show that miR-148a, through its gene targets, plays an important role in regulating skin homeostasis and hair follicle cycling. RNA and protein analysis of miR-148a and its gene targets were analyzed using a combination of in vitro and in vivo experiments.

A novel substrate directed multicomponent reaction for the syntheses of tetrahydro-spiro[pyrazolo[4,3-]quinoline]-8,5'-pyrimidines and tetrahydro-pyrazolo[4,3-]pyrimido[4,5-]quinolines selective multiple C-C bond formation under metal-free conditions.

A versatile and substrate oriented multicomponent reaction for the syntheses of novel highly diastereoselective tetrahydro-1'-spiro[pyrazolo[4,3-]quinoline-8,5'-pyrimidine]-2',4',6'(3')-triones (d.r. up to 20 : 1 ( : )) and tetrahydro-8-pyrazolo[4,3-]pyrimido[4,5-]quinoline-8,10(9)-diones formation of selective multiple C-C bonds under identical reaction conditions ( ethanol as a reaction medium and deep eutectic mixture as a catalyst) is demonstrated.

TNF-α and cancer cachexia: Molecular insights and clinical implications.

Cancer cachexia characterized by a chronic wasting syndrome, involves skeletal muscle loss and adipose tissue loss and resistance to conventional nutritional support. Cachexia is responsible for the reduction in quality and length of life of cancer patients. It also decreases the muscle strength of the patients.

Evaluation of role of telmisartan in combination with 5-fluorouracil in gastric cancer cachexia.

Background: The objective of the present study was to evaluate the effect of combination of telmisartan with 5-flourouracil (5-FU) in gastric cancer cachexia induced by administering N-methyl-N'-methyl-N-nitrosoguanidine (MNNG).

Method: MNND was administered once daily by oral gavage for two weeks, and saturated NaCl (1ml per rat) was then given once every 3days for 4weeks. 5-FU (75mg/kg, i.

An update on pharmacologic management of chronic obstructive pulmonary disease.

Purpose Of Review: Chronic obstructive pulmonary disease (COPD) is a widespread disease process with important clinical and economic implications. This review will summarize new pharmacotherapy for the treatment of COPD.

Recent Findings: Several recent clinical trials have led to the approval of new inhaler therapies for COPD.