[Highly refractive silicone lens with sharp optic edge (CeeOn Edge, Model 911): one year results of a multicenter clinical trial on performance and efficacy].

Purpose: To investigate the performance and efficacy of a new high refractive index (1.46) silicone intraocular lens with sharp optic edges.

Materials And Methods: In this open prospective multicenter study 149 patients underwent cataract surgery and implantation of CeeOn Edge in one eye.

Effect of heparin in irrigating solution on inflammation following small incision cataract surgery.

Purpose: To study the effect of heparin-sodium added to the irrigating solution on postoperative inflammation in patients having cataract surgery.

Setting: Department of Ophthalmology, University of Giessen, Giessen, Germany.

Methods: Seventy-two patients having phacoemulsification with posterior chamber intraocular lens (IOL) implantation were randomly assigned to receive regular irrigating solution or solution with heparin-sodium (final diluted concentration 10 IU/mL).

Pseudophakic retinal detachment in high axial myopia.

Purpose: To investigate the effect of extracapsular cataract surgery with intraocular lens (IOL) implantation and neodymium:YAG (Nd:YAG) laser posterior capsulotomy on the rate of retinal detachment (RD) in myopic eyes with an axial length of 27 mm or more.

Setting: Department of Ophthalmology, University of Giessen, Germany.

Methods: This retrospective, nonrandomized study comprised the records of 386 consecutive surgical procedures in 275 patients performed between December 1985 and December 1993.

Influence of panretinal photocoagulation on the ocular pulse curve.

Purpose: To study the ocular pulsation amplitude (an indicator of choroidal circulation) and systolic ophthalmic artery pressure after panretinal photocoagulation.

Methods: Prospectively, in 10 patients with diabetes mellitus (eight with type II and two with type I; mean age, 64 years) and severe, hitherto untreated, bilateral proliferative diabetic retinopathy, we performed intensive, unilateral panretinal photocoagulation with 1,500 argon laser burns (spot size, 500 microm) in two sessions (interval, 3 weeks). Before and (in 3-week intervals) up to 9 weeks after treatment, we recorded ocular pulse curves using oculo-oscillodynamography and determined each patient's ocular pulsation amplitude and systolic ophthalmic artery pressure.

Influence of the vasodilator drug isosorbide dinitrate on ocular circulation.

Objective: To evaluate the ocular hemodynamic effects of the vasodilator drug isosorbide dinitrate.

Design: Randomized, prospective, controlled clinical trial assessing the short-term effects of 1 tablet containing 40 mg of isosorbide dinitrate vs placebo.

Setting: Department of Ophthalmology, University of Giessen, Germany.

Reduced ocular pulse amplitude in low tension glaucoma is independent of vasospasm.

Purpose: A vascular basis for the pathogenesis of primary open angle glaucoma has been postulated for many years. Defects in the regulation of ocular blood flow may be the initiating factor in this group of multifactorial diseases. This study was designed to evaluate the effect of vasospasm on ocular pulse amplitude (OPA) in low tension glaucoma (LTG) patients.

[Effect of panretinal photocoagulation on the ocular pulse curve].

Background: Most studies on the effects of panretinal photocoagulation (PRPC) on ocular circulation are concerned with retinal circulation. In the present study, we examined the ocular pulse curve after PRPC and determined pulsatile ocular blood flow (an indicator of choroidal circulation) and ocular perfusion pressure.

Patients And Method: In 10 patients with diabetes mellitus (8 with type II and 2 with type I; mean age 64 yrs) and severe, hitherto untreated, bilateral proliferative diabetic retinopathy, an intensive unilateral PRPC with 1500 argon laser burns (spot size: 500 mu) was performed in 2 sessions (interval: 3 wks).

[Minor effect of anti-inflammatory therapy on intraocular inflammation after minimally invasive phacoemulsification].

Unlabelled: In a prospective study, we examined the influence of different anti-inflammatory treatments on intraocular inflammation after minimally invasive cataract surgery.

Patients And Methods: A total of 150 patients (39-88 years of age) underwent phacoemulsification using a temporal clear-corneal tunnel incision and implantation of a 5-mm PMMA posterior chamber. Each patient was randomly assigned to one of the following 5 treatment groups, each consisting of 30 patients: (1) diclofenac 0.

[Minimally inflammatory cataract surgery].

Background: Cataract surgery leads to a more or less intensive postoperative inflammation due to breakdown of the blood-aqueous barrier. In a prospective, randomized and controlled clinical trial, we examined aqueous flare as well as intraocular pressure and visual acuity after a minimally invasive cataract surgical procedure under different anti-inflammatory treatment.

Patients And Method: In 150 patients (39-88 years of age) without glaucoma or pre-existing deficiencies of the blood-aqueous barrier, phacoemulsification through a clear-corneal tunnel incision with implantation of a 5 mm PMMA posterior chamber intraocular lens was performed.

[Viscoelastic substances in cataract surgery. Principles and current overview].

The major aim for the application of viscoelastic substances in cataract surgery is prevention of corneal endothelial cell loss. This aim is fulfilled by deepening of the anterior chamber, mechanical endothelium protection against surgical trauma, absorption of ultrasound energy, and coating of intraocular lens. The first and mostly used viscoelastic in ophthalmic surgery is a 1% solution of sodium hyaluronate (NaHA) with a molecular weight of 4 million daltons, and a viscosity of 229,000 cP (Healon).

Influence of physical exercise and nifedipine on ocular pulse amplitude.

Background: Ocular pulse amplitude (OPA) was measured to investigate the influence of peripheral vasoconstriction and vasodilation on choroidal perfusion in healthy volunteers and to determine whether low OPA in low-tension glaucoma (LTG) patients is associated with a vasospastic reaction and its response to the calcium channel blocker nifedipine.

Methods: OPA was determined using the Langham ocular blood flow (OBF) system, applanation intraocular pressure (IOP), systemic blood pressure, and heart rate were measured, and ocular perfusion pressure was calculated before and after exercise and smoking in 12 otherwise nonsmoking, healthy volunteers and prior to and for 3 months after initiation of nifedipine therapy in 32 LTG patients with and without a vasospastic reaction as manifested by a nailfold capillary blood flow test.

Results: Exercise significantly (P < 0.

[Effect of the vasodilator isosorbide dinitrate on ocular circulation].

Background: Vasodilator drugs are increasingly being discussed as possible antiglaucomatous substances. Aim of the present study is to evaluate, from a hemodynamic point of view, the vasodilator drug isosorbide dinitrate (ISDN) regarding its suitability for glaucoma therapy.

Methods: 20 healthy subjects (mean age: 28 yrs) volunteered to participate in the study.

[Anti-inflammatory effects and aqueous humor concentration of various nonsteroidal anti-inflammatory drugs in extracapsular cataract surgery].

Background: Within the spectrum of anti-inflammatory drugs, the preference of nonsteroidal anti-inflammatory drugs (NSAID) is definitely increasing. In the present study, we compared the anti-inflammatory effects and aqueous humour concentrations of 3 topical NSAID (indomethacin, diclofenac, and flurbiprofen) during extracapsular cataract surgery.

Patients And Methods: We examined 90 patients (52-89 yrs of age) without pre-existing deficiencies of the blood-aqueous barrier.

[Motor blockade by retrobulbar anesthesia. Phenomenology and mechanism of action].

Unlabelled: The aim of this study was to analyze quantitatively the phenomenology and mechanisms of motor blockade induced by retrobulbar anesthesia (RETRO).

Patients And Methods: Prior to cataract surgery, 34 patients received RETRO using the intraconal technique of Atkinson. Four milliliters of mepivacaine 2% (Scandicain), prilocaine 2% (Xylonest) or lidocaine 2% (Xylocain) were injected in randomized order.

[Is subconjunctival steroid administration in addition to local therapy after cataract operations necessary? A laser tyndallometric study].

Unlabelled: Subconjunctival steroids are often injected at the end of cataract surgery. In the present laser flare-cell meter study, we investigated whether this procedure improves the anti-inflammatory effect of steroid eye drops.

Patients And Methods: Thirty patients (69-81 years of age) without preexisting deficiencies of the blood-aqueous barrier were investigated preoperatively and after ECCE with PC-IOL implantation.

[The anti-inflammatory effect of heparin-containing infusion solutions during phacoemulsification].

Unlabelled: The use of heparin prevented postoperative intraocular fibrin-clot formation in the rabbit after vitrectomy and cyclocryotherapy. A low rate of postoperative intraocular inflammation was observed in our patients receiving phacoemulsification with heparin infusion solution (slit-lamp examination). To verify this effect a randomized, prospective study was performed using laser-flare cell photometry (LFCP) for measuring protein concentration in the anterior chamber.

[Monotherapy vs combination therapy with topical prednisolone and indomethacin].

Unlabelled: The anti-inflammatory effects of topical steroids and nonsteroidal anti-inflammatory drugs (NSAID) are claimed to be additive, according to fluorophotometric measurements. This finding was reevaluated using laser flare-cell photometry.

Patients And Methods: Thirty patients (61-79 years of age) without pre-existing deficiencies of the blood-aqueous barrier were investigated preoperatively as well as on day 1 and 3 after ECCE with IOL implantation.

[Mesoptic vision in multi- and monofocal pseudophakia and in phakic control eyes].

Unlabelled: The mesopic visual acuity (MVA) after intraocular lens (IOL) implantation is reduced compared to phakic patients of the same age. However, previous studies from our clinic have shown no significant MVA difference between multi- and monofocal IOLs. In the present study (with the patients matched exactly for age), this topic was reevaluated.

[Systemic complications and side effects of retrobulbar anesthesia in risk patients].

Background: Serious systemic complications with possibly lethal exit after retrobulbar anesthesia have been reported. The present study was performed to evaluate the incidence of complications after anesthesia in risk patients with pre-existing diseases. 2.

[Anti-inflammatory effect of a local combination therapy with diclofenac and prednisolone vs. indomethacin and prednisolone. A laser flare cell photometry study].

Unlabelled: The nonsteroidal anti-inflammatory agent diclofenac (Voltaren) has recently become commercially available in form of 0.1% eyedrops (Voltaren ophtha). In the present study, we compared the anti-inflammatory effect of a topical combination therapy with diclofenac and prednisolone vs.

[Peribulbar anesthesia versus retrobulbar anesthesia with facial nerve block. Techniques, local anesthetics and additives, akinesia and sensory block, complications].

Background: Retrobulbar anesthesia (RETRO), combined with a facial block, is the most frequently employed method of anesthesia in cataract surgery. There is, however, an increasing tendency to use peribulbar anesthesia (PERI), which is claimed to provide the same degree of anesthesia and akinesia as RETRO while reducing many of the complications.

Objectives Of The Study: Survey of the principal techniques of RETRO, facial block and PERI as well as of the most important local anesthetics and additives; quantitative investigation of resulting akinesia and sensory blockade; comparison of systemic and local complications (literature review).

[Reproducibility of in vivo determination of protein and particle concentration with the laser flare cell photometer].

The laser flare-cell photometer was introduced as an instrument to measure anterior chamber inflammation (protein concentration and particle concentration, "cells") quantitatively and non-invasively. Thirty-two eyes with and without intraocular inflammation were examined using the laser flare-cell photometer by three different examiners under the same conditions to determine the reproducibility. The coefficients of variation of flare (Vfi) and of number of cells (Vci) were calculated for each eye (i).

[Scanning electron microscopy examination of 87 pre-injection blunted retrobulbar cannulas].

Unlabelled: The use of blunt cannulas for retrobulbar injection (retro) is recommended to reduce the risk of retrobulbar hemorrhage and globe perforation. Retro cannulas with blunt tips--so-called Atkinson needles--are commercially available. They can also be produced by being blunted on a sterile surface immediately before injection.