Attenuation of Human Growth Hormone-Induced Rash With Graded Dose Challenge.

Adult growth hormone (GH) deficiency is rare and requires replacement with extrinsic/synthetic injection. GH hypersensitivity has been reported; specifically, atopic patients may develop rashes from somatotropin therapy. Allergic and non-allergic skin reactions to recombinant human GH are uncommon and infrequently reported.

Uncovering the intricacies of microbial community dynamics at Helgoland Roads at the end of a spring bloom using automated sampling and 18S meta-barcoding.

In May 2016, the remote-controlled Automated Filtration System for Marine Microbes (AUTOFIM) was implemented in parallel to the Long Term Ecological Research (LTER) observatory Helgoland Roads in the German Bight. We collected samples for characterization of dynamics within the eukaryotic microbial communities at the end of a phytoplankton bloom via 18S meta-barcoding. Understanding consequences of environmental change for key marine ecosystem processes, such as phytoplankton bloom dynamics requires information on biodiversity and species occurrences with adequate temporal and taxonomic resolution via time series observations.

How feeling betrayed affects cooperation.

For a population of interacting self-interested agents, we study how the average cooperation level is affected by some individuals' feelings of being betrayed and guilt. We quantify these feelings as adjusted payoffs in asymmetric games, where for different emotions, the payoff matrix takes the structure of that of either a prisoner's dilemma or a snowdrift game. Then we analyze the evolution of cooperation in a well-mixed population of agents, each of whom is associated with such a payoff matrix.

Femoroacetabular impingement in athletes.

Besides professional sports, what do Alex Rodriguez, Michelle Kwan, and Greg Norman have in common? They all suffered from a condition called femoroacetabular impingement, or FAI. First identified by Dr. Reinhold Ganz, an orthopaedic surgeon in the mid-1990s, FAI has gained recognition in recent years as more professional athletes have been diagnosed with this condition.

Intraflagellar transport gene expression associated with short cilia in smoking and COPD.

Smoking and COPD are associated with decreased mucociliary clearance, and healthy smokers have shorter cilia in the large airway than nonsmokers. We hypothesized that changes in cilia length are consistent throughout the airway, and we further hypothesized that smokers with COPD have shorter cilia than healthy smokers. Because intraflagellar transport (IFT) is the process by which cilia of normal length are produced and maintained, and alterations in IFT lead to short cilia in model organisms, we also hypothesized that smoking induces changes in the expression of IFT-related genes in the airway epithelium of smokers and smokers with COPD.

Fish oil supplementation for management of dyslipidemia.

The use of herbal and natural remedies to prevent and manage disease is increasing in popularity. Individuals are attracted to the nonsynthetic qualities, affordability, and purity of natural remedies as compared to standard pharmacological and invasive interventions. Fish oil supplementation, for example, has been used in the management of dyslipidemia in patients choosing a natural approach to treatment or in adjunct to prescribed medication regimens.

Presence in nursing practice: a concept analysis.

Presence is an elusive concept in nursing practice that has been recognized as advantageous in the patient experience. Dictionary sources define presence as being with and attending to another; involvement, companionship. Nursing scholars and theorists have elaborated on the dictionary definition of presence to include a holistic definition inclusive of the patient experience and the connection experienced between both patient and provider.

Primate mating systems and the evolution of immune response.

White blood cell (WBC) and red blood cell (RBC) counts were examined in a sample comprising 762 specimens, representing 25 genera and 38 species of captive non-human primates. Animals suffering from illnesses exhibited higher WBC counts than healthy specimens sampled during routine health checks. Analysis of basal WBC counts in healthy animals confirmed a positive correlation between higher cell counts and occurrences of multiple partner mating.

Antihypertensive efficacy and acceptability of rilmenidine in elderly hypertensive patients.

Elderly hypertensive patients (older than 70 years, with a diastolic blood pressure [BP] between 95 and 114 mm Hg) were entered into a study after a 2-week wash-out period and randomized to 2 parallel groups: rilmenidine (n = 28) and methyldopa (n = 30). The initial dose (rilmenidine, 1 mg once daily A.M.

Reduced hexose transport by enterocytes associated with rapid, noninjurious rejection of Trichinella spiralis from immune rats.

Rats immunized against Trichinella spiralis rejected larvae from a challenge infection within minutes. Infectivity of these once-rejected larvae for nonimmune rats following intestine-to-intestine transfer, infectivity for nonimmune mice following oral inoculation, and normal development in these mice indicated that the parasite did not sustain immediate or long term damage as a result of the host's immune response. Associated with rapid worm rejection was a change in host intestinal function - altered absorption.

Altered intestinal fluid movement in response to Trichinella spiralis in immunized rats.

Net intestinal fluid movement was measured in immunized and non-immunized rats infected with the enteric stages of the nematode, Trichinella spiralis. Animals were studied 30 min, 5 days and 30 days after receiving infective larvae. Net water movement across the mucosal surface of the gut was measured in vivo by perfusing a cannulated segment (approximately 30 cm) of proximal small intestine with an isotonic solution containing a nonabsorbable marker, 14C polyethylene glycol, at a rate of 0.