Bis(dimethylpyrazolyl)-aniline--triazine derivatives as efficient corrosion inhibitors for C-steel and computational studies.

4,6-Bis(3,5-dimethyl--pyrazol-1-yl)--phenyl-1,3,5-triazin-2-amine (), -(4-bromophenyl)-4,6-bis(3,5-dimethyl--pyrazol-1-yl)-1,3,5-triazin-2-amine () and 4,6-bis(3,5-dimethyl--pyrazol-1-yl)--(4-methoxyphenyl)-1,3,5-triazin-2-amine () were synthesized and characterized. Their corrosion inhibition of carbon C-steel in 0.25 M HSO was studied by electrochemical impedance.

Green Synthesis of Magnetic Supramolecules β-Cyclodextrin/Iron Oxide Nanoparticles for Photocatalytic and Antibacterial Applications.

Iron oxide nanoparticles (FeONPs) are a fascinating field of study due to their wide range of practical applications in environmental and medical contexts. This study presents a straightforward, environmentally friendly method for producing FeONPs utilizing β-cyclodextrin (β-CD) as a reducing and capping agent. This approach results in the rapid and effective eco-friendly synthesis of β-CD/FeONPs.

Corrigendum: Pyrazolyl-s-triazine with indole motif as a novel of epidermal growth factor receptor/cyclin-dependent kinase 2 dual inhibitors.

[This corrects the article DOI: 10.3389/fchem.2022.

Pyrazolyl-s-triazine with indole motif as a novel of epidermal growth factor receptor/cyclin-dependent kinase 2 dual inhibitors.

A series of pyrazolyl--triazine compounds with an indole motif was designed, synthesized, and evaluated for anticancer activity targeting dual EGFR and CDK-2 inhibitors. The compounds were tested for cytotoxicity using the MTT assay. Compounds , , and showed promising cytotoxic activity against two cancer cell lines, namely A549, MCF-7, and HDFs (non-cancerous human dermal fibroblasts).

Synthesis and characterization of photo-crosslinkable cinnamate-functionalized pectin.

The polysaccharide pectin (PC) was functionalized with the photo-responsive cinnamic acid hydrazide (CN) to produce the photo-crosslinkable PC-CN hydrogel material that was then evaluated as a carrier for encapsulation of the drug model aspirin. Cinnamic acid hydrazide was first prepared and then incorporated with the abundant -COOCH groups on the pectin chain via hydrazide linkage. The obtained polymeric derivatives have been characterized by means of instrumental techniques including FTIR and NMR.

Syntheses and Structural Investigations of Penta-Coordinated Co(II) Complexes with -Pyrazolo--Triazine Pincer Ligands, and Evaluation of Their Antimicrobial and Antioxidant Activities.

Two penta-coordinated ; and ; complexes with the -pyrazolyl--triazine pincer ligands and were synthesized and characterized. Both and act as NNN-tridentate pincer chelates coordinating the Co(II) center with one short Co-N(-triazine) and two longer Co-N(pyrazole) bonds. The coordination number of Co(II) is five in both complexes, and the geometry around Co(II) ion is a distorted square pyramidal in while shows more distortion.

Fe(III) Complexes Based on Mono and Bis-pyrazolyl--triazine Ligands: Synthesis, Molecular Structure, Hirshfeld, and Antimicrobial Evaluations.

The self-assembly of iron(III) chloride with three pyrazolyl--triazine ligands, namely 2,4-bis(3,5-dimethyl-1-pyrazol-1-yl)-6-(piperidin-1-yl)-1,3,5-triazine (), 4-(4,6-bis(3,5-dimethyl-1-pyrazol-1-yl)-1,3,5-triazin-2-yl)morpholine (), and 4,4'-(6-(3,5-dimethyl-1-pyrazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine () afforded [Fe(BPT)Cl][FeCl] (), [Fe(BPT)Cl][FeCl] (), and [H(PT)][FeCl]. PT.2HO (), respectively, in good yield.

Ultrasonically Assisted -Cyanoacylation and Synthesis of Alkyl(4-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2)-yl)benzoyl)amino Acid Ester Derivatives.

This work represents the use of -3-(3,5-dimethyl-1-pyrazol-1-yl)-3-oxopropanenitrile as a cyanoacetylating agent for the synthesis of cyanoacetamide benzoic acid and benzophenone derivatives by two different methods, namely, conventional heating and ultrasonication. The cyanoacetamide derivatives were subjected to cyclization to produce N-substituted 2-pyridone derivatives under conventional heating and by an ultrasonic method as well. The ultrasonic method afforded the products in less reaction time with high yields and purities compared to the conventional method, as observed from their spectral data.

Synthesis, Anti-proliferative Activity, and Molecular Docking Study of New Series of 1,3-5-Triazine Schiff Base Derivatives.

Based on the use of -triazine as a scaffold, we report here a new series of -triazine Schiff base derivatives and their anti-proliferative activity against two cancer cell lines: human breast carcinoma (MCF-7), and colon cancer (HCT-116) compared with tamoxifen as a reference compound. Several derivatives exhibited growth inhibition activity in the sub-micromolar range. The results reveal that the -triazine Schiff base derivatives showed varied activities and that the substituents on the -triazine core have a great effect on the anti-proliferative activity.

Synthesis and Characterization of New Series of 1,3-5-Triazine Hydrazone Derivatives with Promising Antiproliferative Activity.

A new series of -triazine hydrazone derivatives was prepared based on the reaction of 6-hydrazino-2,4-disubstituted--triazine with -substituted benzaldehyde derivatives using a straightforward synthetic pathway. The antiproliferative activity of all synthesized compounds was evaluated against two human cancer cell lines; breast cancer MCF-7 and colon carcinoma HCT-116 using MTT assay. Among all, 11 compounds have shown strong to moderate antiproliferative activity with IC values in the range 1.

Simple Approaches for the Synthesis of AgNPs in Solution and Solid Phase Using Modified Methoxypolyethylene Glycol and Evaluation of Their Antimicrobial Activity.

Purpose: Simple methodology for preparation of metal nanoparticles such as AgNPs uses an methanolic aqueous medium at room temperature or a solvent-free procedure under microwave irradiation. The prepared AgNPs showed a significant antimicrobial effect against Gram-positive bacteria, Gram-negative bacteria, and fungi.

Methods: The modified methoxypolyethylene glycol bishydrazino-s-triazine (mPEGTH2) showed remarkable activity for reducing Ag to Ag in an aqueous methanolic solution and using a solvent-free method (solid phase) under microwave irradiation.

Synthesis and characterisation of thiobarbituric acid enamine derivatives, and evaluation of their α-glucosidase inhibitory and anti-glycation activity.

A new series of thiobarbituric (thiopyrimidine trione) enamine derivatives and its analogues barbituric acid derivatives was synthesised, characterised, and screen for evaluation of α-glucosidase enzyme inhibition and anti-glycation activity. This series of compounds were found to inhibit α-glucosidase activity in a reversible mixed-type manner with IC between 264.07 ± 1.