Publications by authors named "Hessa Alduhailan"
Article Synopsis
- VPA, commonly prescribed for psychiatric and neurological disorders, may cause kidney injury with chronic use; this study investigates the underlying mechanisms and potential protective strategies.
- Rats were divided into groups for testing VPA-induced kidney damage and subsequent treatments with indole-3-acetic acid (IAA) and chenodeoxycholic acid (CDCA) to assess their protective effects.
- Results showed that VPA reduced antioxidant levels and increased inflammatory markers in kidneys, but IAA and CDCA effectively improved these conditions by enhancing antioxidant defenses and reducing inflammation.
Stress-related disorders are extremely complex and current treatment strategies have limitations. The present study investigated alternative pathological mechanisms using a combination of multiple environmental approaches with biochemical and molecular tools. The aim of the present study was to evaluate blood-brain-barrier (BBB) integrity in socially manipulated animal housing conditions.
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