[Biological availability of digoxin and beta-methyl-digoxin administered in the fasting state or after meals].

Ten healthy volunteers were given 0.75 mg digoxin and 0.5 mg beta-methyl-digoxin (BMD) in tablet form in the fasting state or after breakfast.

[Immunological treatment of digitalis poisoning with heterologous antibodies].

Our own experience with the production of digoxin-specific antibody preparations from the sheep and the results of the experimental and clinical use are briefly reviewed. Advantages, risks and unsolved problems of therapy with glycoside-specific antibodies are discussed.

[Underdosing and overdosing with digitalis].

Incorrect dosage of digitalis occurs frequently and is due in most cases to relative over- or underdosage. The narrow therapeutic range of all cardiac glycosides and the lack of an ideal preparation form the basis, and noncompliance of the ill-informed patient as well as the changing digitalis requirement from patient to patient, and even in the same patient, are the most frequent causes of dosage errors. Important guidelines for the dosage of digoxin and digitoxin (renal failure, diseases of the liver and gastrointestinal tract, body weight, age, electrolyte disorders, hypoxia, thyroid dysfunction and drug interactions) are discussed.

[Features and treatment of heart failure in old age].

Heart failure is a syndrome with many causes and well known symptoms, which are mentioned in the introduction. In aged people coronary and hypertensive cardiopathy are the main causes of heart failure, and only rarely do senile changes of the heart play a role. A causal therapy cannot be performed in most cases since in old age several heart diseases and concommittant affections are combined.

[The treatment of digitalis poisoning with antibiotics (author's transl)].

Digitalis intoxication occurs frequently and proves fatal in 5-10% of all cases. Treatment is limited to symptomatic measures. Glycoside-specific antibodies offer a new way of treatment of digitalis intoxication.

The effectiveness of digoxin-specific F(ab')2-antibody fragments in the treatment of digitoxin poisoning: experimental investigations in the cat.

In animal experiments heterologous digoxin-specific F(ab')2 antibody fragments have been found to be effective for the treatment of arrhythmias induced by toxic doses of digoxin. So far they have been successfully employed in three patients suffering from digoxin poisoning. The present study was undertaken to test whether these antibodies are also effective in the treatment of digitoxin poisoning.

Transient global amnesia after clioquinol: five personal observations from outside Japan.

Five personal observations of an acute amnestic episode in younger individuals after intake of clioquinol are described together with three observations from the medical literature. In five of these cases the episode began after an unusually large dose, in three after a therapeutic one with a latency of about 24 hours. The clinical aspect closely resembled classical transient global amnesia but the episode after clioquinol lasted longer (24 hours to three days) and a more or less extensive retrograde amnesia persisted permanently.

[Antibody treatment of digoxin intoxication in a patient with renal failure (author's transl)].

A 72-year-old man with coronary heart disease and renal failure required hospitalization because of digoxin intoxication with severe arrhythmias and generalised heart failure. The intoxication was successfully treated and sinus rhythm rapidly restored after administration of heterologous digoxin-specific F(ab')2 antibody fragments. There were no side-effects and the heart failure improved after treatment.

Field evaluation of selected monitoring methods for phosgene in air.

Four selected methods have been evaluated and field tested as candidates for a specific, continuous procedure for monitoring phosgene in air at or below concentrations of 0.05 ppm. The methods evaluated were automated colorimetry, gas chromatography, infrared spectrophotometry and a recently developed paper tape monitor.

The prevention and reversal of digoxin intoxication with specific antibodies.

The formation of digoxin-specific antibodies was induced in sheep by immunization with a digoxin-albumin conjugate. The efficacy of the antibodies was investigated in anesthetized cats. When the digoxin-specific antibodies were administered prophylactically as a gammaglobulin, IgG or F (ab')2 preparation, the dose of digoxin needed to induce ventricular dysrhythmia was significantly greater (p less than 0.

Biotransformation products of 3,4,4'-trichlorocarbanilide in rat, monkey, and man.

3,4,4'-Trichlorocarbanilide (TCC), uniformly labeled with 14C in the monochloro ring, was administered to rats, rhesus monkeys, and humans. Radioactive materials in the plasma and urine of all three species and in the bile of rats and monkeys were separated by high performance liquid chromatography. The chromatography showed great similarity between the monkey and the human.

[Sclerosing peritonitis and practolol (author's transl)].

Skin manifestations, eye complications, a nephrotic syndrome, appearance of lupus erythematosus cells and antinuclear antibodies, sometimes combined with a systemic side effects of the beta adrenergic blocker Practolol. Another side effect is though to be sclerosing peritonitis. The latter is identical with the idiopathic fibroplastic peritonitis, described at the turn of this fibroplastic peritonitis, described at the turn of this century by German authors.