Effect of madecassic acid on retinal oxidative stress, inflammation and Growth Factors in streptozotocin-induced diabetic rats.

Diabetic retinopathy (DR) is the leading cause of blindness and visual loss in people with diabetes. It has been suggested that the progression of DR is associated with chronic inflammation and oxidative stress. The aim of the present work was to evaluate the ability of the natural compound madecassic acid (MEA) to reverse the negative impact of streptozotocin (STZ) on retinal injury in rats.

Fabrication of ibuprofen/naringenin-coloaded into zein/sodium caseinate nanoparticles: evaluation of antiproliferative activity and apoptosis induction in liver cancer cells.

Nowadays, liver cancer is one of the most disturbing types of cancer that can affect either sex. Nanoparticles (NPs) of zein/sodium caseinate incorporating ibuprofen (IBU) and naringenin (NAR) have improved bioavailability and a high encapsulation efficiency (EE%). These nanoparticles are uniformly spherical.

Cu-W bimetallic nanoparticles decorated g-CN sheets: Facile construction and characterization for perception of dopamine in sensing application.

In this study, we present the development and analysis of electrochemical sensors utilizing graphitic carbon nitride copper-tungsten nanoparticles (g-CN @Cu-W Nps) capped with various cationic surfactants of differing chain lengths and counter ions. The fabricated nanoparticles underwent thorough characterization to assess their morphological, structural, and compositional attributes, revealing their uniformity, spherical morphology, and monoclinic crystal phases. Subsequently, these nanoparticles were employed in the fabrication of electrochemical sensors for hydrazine detection.

Solanine Inhibits Proliferation and Angiogenesis and Induces Apoptosis through Modulation of EGFR Signaling in KB-ChR-8-5 Multidrug-Resistant Oral Cancer Cells.

The most important factors contributing to multi-drug resistance in oral cancer include overexpression of the EGFR protein and the downstream malignancy regulators that are associated with it. This study investigates the impact of solanine on inflammation, proliferation, and angiogenesis inhibition in multidrug-resistant oral cancer KB-Chr-8-5 cells through inhibition of the EGFR/PI3K/Akt/NF-κB signaling pathway. Cell viability was assessed using an MTT assay to evaluate cytotoxic effects.

Role of chitinase expression in the virulence of Lecanicillium lecanii against citrus black aphid (Toxoptera aurantii).

Chitinase plays a vital role in the virulence of entomopathogenic fungi (EPF) when it infects host insects. We used gene recombination technology to express chitinase of three strains of Lecanicillium lecanii: Vl6063, V3450, and Vp28. The ORF of ChitVl6063, ChitV3450 and ChitVp28 were inserted into the fungal expression vector pBARGPE-1, which contained strong promoter and terminator, respectively, to construct a chitinase overpressing plasmid, then transformed the wild-type strain with blastospore transformation method.

Comparative analysis of nutrient composition and antioxidant activity in three dragon fruit cultivars.

Dragon fruit has significant economic value in many countries due to has excellent nutritional content, health advantages, and adaptability to different climates, making it an important crop in the global fruit industry. This study aimed to gather comprehensive nutritional data on three dragon fruit cultivars by analysing the levels of micronutrients, fibre, carbohydrates, antioxidants, vitamins, and minerals in their pulps. Uniform dragon fruit samples underwent thorough analysis for proximate composition, mineral content, pigments, antioxidants, and vitamin C, with statistical methods used to assess significant differences among the parameters studied.

Unveiling soil animal community dynamics beneath dominant shrub species in natural desert environment: Implications for ecosystem management and conservation.

The Taklimakan Desert, known for extreme aridity and unique ecological challenges, maintains a delicate life balance beneath its harsh surface. This study investigates intricate dynamics of soil animal communities within this desert ecosystem, with a particular focus on vertical profile variations beneath four dominant shrub species (AS-Alhagi sparsifolia, KC-Karelinia caspia, TR- Tamarix ramosissima, CC- Calligonum caput-medusae). Utilizing comprehensive soil sampling and metagenomics techniques, we reveal the diversity and distribution patterns of soil animal communities from the soil surface down to deeper layers (0-100 cm).

Photodegrading rhodamine B dye with cobalt ferrite-graphitic carbon nitride (CoFeO/g-CN) composite.

The present research utilizes a sol-gel approach to create a CoFeO/g-CN nanocomposite (NC) and explored several analytical methods to evaluate physical, chemical and optical based characteristics via XRD, FTIR, UV-vis, SEM/EDS and XPS for the prepared pure CoFeO, g-CN, and CoFeO/g-CN NC. The XRD results show that the prepared g-CN, CoFeO, exhibits hexagonal and cubic phases respectively, whereas the g-CN/CoFeO NC exhibit mixing of two phases. The energy band gaps for pure g-CN, CoFeO and g-CN/CoFeO NC values are viz.

Minimization of heavy metal toxicity in radish (Raphanus sativus) by strigolactone and biochar.

Due to the high solubility of Cd in water, it is considered a potential toxin which can cause cancer in humans. In plants, it is associated with the development of oxidative stress due to the generation of reactive oxygen species. To overcome this issue, the roles of different plant hormones are vital.

Combined effect of gallic acid and zinc ferrite nanoparticles on wheat growth and yield under salinity stress.

Salinity stress significantly impacts crops, disrupting their water balance and nutrient uptake, reducing growth, yield, and overall plant health. High salinity in soil can adversely affect plants by disrupting their water balance. Excessive salt levels can lead to dehydration, hinder nutrient absorption, and damage plant cells, ultimately impairing growth and reducing crop yields.

Effect of methyl jasmonate and GA3 on canola (Brassica napus L.) growth, antioxidants activity, and nutrient concentration cultivated in salt-affected soils.

Salinity stress is a significant challenge in agricultural production. When soil contains high salts, it can adversely affect plant growth and productivity due to the high concentration of soluble salts in the soil water. To overcome this issue, foliar applications of methyl jasmonate (MJ) and gibberellic acid (GA3) can be productive amendments.

GC-MS based antioxidants characterization in Saussurea heteromalla (D. Don) Hand-Mazz by inhibition of nitric oxide generation in macrophages.

For centuries, medicinal plants have served as the cornerstone for traditional health care systems and same practice is still prevalent today. In the Himalayan region, Saussurea heteromalla holds a significant place in traditional medicine and is used to address various health issues. Despite its historical use, little exploration has focused on its potential for scavenging free radicals and reducing inflammation.

Myricetin Attenuates Ethylene Glycol-Induced Nephrolithiasis in Rats via Mitigating Oxidative Stress and Inflammatory Markers.

Urolithiasis or nephrolithiasis is a condition of kidney stone formation and is considered a painful disease of the urinary tract system. In this work, we planned to discover the therapeutic roles of myricetin on the ethylene glycol (EG)-induced nephrolithiasis in rats. The experimental rats were treated with 0.

Anti-Allergic and Anti-inflammatory Effects of Bakuchiol on Ovalbumin-Induced Allergic Rhinitis in Mice.

Allergic rhinitis (AR) is a prevalent inflammatory disease primarily affecting the nasal mucosa and is caused by allergies. The common symptoms of AR include rhinorrhea, sneezing, itchy nose, congestion, teary eyes, and nasal rubbings. The present study assessed the beneficial properties of bakuchiol on OVA-induced AR in mice via the regulation of inflammatory responses.

Antioxidant and anticancer potential of ethyl acetate extract of bark and flower of Tecoma stans (Linn) and In Silico studies on phytoligands against Bcl 2 and VEGFR2 factors.

This study was designed to appraise the antioxidant and anticancer competence of solvent extracts of Tecoma stans (Linn) and analyze the phytoligands interaction against Bcl 2 VEGFR2 through in silico studies. The phytochemical analysis revealed that the ethyl acetate extract contains more number of pharmaceutically valuable phytochemicals than other solvent extracts. Among the various phytochemicals, flavonoid was found as a predominant component, and UV-Vis- spectrophotometer analysis initially confirmed it.

Simultaneous quantification of losartan potassium and its active metabolite, EXP3174, in rabbit plasma by validated HPLC-PDA.

Herein, we report a novel, accurate and cost-effective validated analytical method for the quantification of losartan potassium and its active metabolite, EXP 3174, in rabbit plasma by reversed-phase high-performance liquid chromatography. Valsartan was used as an internal standard. The method was validated as per International Conference on Harmonization guidelines.

Utilisation of persistent chemical pollutant incorporating with nanoparticles to modify the properties of geopolymer and cement concrete.

The majority of industrial products are identified as persistent organic pollutants after their date of expiry, which is highly harmful to the ecosystem and human health and also going to be banned around the world. Paint latex is one of those pollutants which become a hazardous waste material after stocking for a long time. Approximately 20% of color paints do not get used for their desired purpose after getting sold out and end up in a landfill.

IOTEML: An Internet of Things (IoT)-Based Enhanced Machine Learning Model for Tumour Investigation.

In the current age of technology, various diseases in the body are also on the rise. Tumours that cause more discomfort in the body are set to increase the discomfort of most patients. Patients experience different effects depending on the tumour size and type.

An Image Processing Approach for Detection of Prenatal Heart Disease.

Prenatal heart disease, generally known as cardiac problems (CHDs), is a group of ailments that damage the heartbeat and has recently now become top deaths worldwide. It connects a plethora of cardiovascular diseases risks to the urgent in need of accurate, trustworthy, and effective approaches for early recognition. Data preprocessing is a common method for evaluating big quantities of information in the medical business.

Dental Students' Perception, Awareness and Knowledge About HPV Infection, Vaccine, and Its Association with Oral Cancer: A Multinational Study.

Background: Human papilloma virus (HPV) infection forms a major etiological factor for oropharyngeal cancer (OPC), which has exhibited increased global incidence.

Aim: To compare the knowledge regarding HPV, its association with OPC, and HPV vaccine among students from different countries, years of the undergraduate program, and gender.

Methods: The current multinational cross-sectional study was conducted in 886 undergraduate dental students from Egypt, India, Pakistan, Saudi Arabia, UAE, and Sudan through Google survey forms from July 2021 to September 2021.

A Deep Learning Framework for Earlier Prediction of Diabetic Retinopathy from Fundus Photographs.

Diabetic patients can also be identified immediately utilizing retinopathy photos, but it is a challenging task. The blood veins visible in fundus photographs are used in several disease diagnosis approaches. We sought to replicate the findings published in implementation and verification of a deep learning approach for diabetic retinopathy identification in retinal fundus pictures.

Dental students and COVID 19: An online multinational survey on perception and knowledge.

Background: Coronavirus is an emerging respiratory pathogen that causes coronavirus disease-2019 (COVID-19), as per the Chinese Center for Disease Control and Prevention.

Objective: This study aimed to assess the state of awareness and extent of knowledge about COVID-19 among dental students from India, Pakistan, and Saudi Arabia.

Materials And Methods: The present descriptive cross-sectional study was conducted on 872 participants from December 2020 to January 2021.

Investigation on Inorganic Salts K2TiF6 and KBF4 to Develop Nanoparticles Based TiB2 Reinforcement Aluminium Composites.

In the current research, AA6082 aluminium alloy matrix composites (AAMCs) incorporated with various weight fractions of titanium diboride (0, 3, 6, and 9 wt%) were prepared via an in situ casting technique. The exothermic reaction between inorganic powders like dipotassium hexafluorotitanate (K2TiF6) and potassium tetrafluoroborate (KBF4) in molten Al metal contributes to the development of titanium diboride content. The manufactured AA6082-TiB2 AAMCs were evaluated using a scanning electron microscope (SEM) and X-ray diffraction (XRD).

A novel synthesis, analysis and evaluation of Musa coccinea based zero valent iron nanoparticles for antimicrobial and antioxidant.

Zerovalent Iron Nanoparticles (MC-ZVI NPs) were synthesized from Musa coocinea peel extract as reducing and stabilizing agent using a novel synthesis technique. The synthesis of MC-ZVI NPs was confirmed using UV-vis spectroscopy showing a sharp absorption peak at 341 nm. Further the chemical and structural characterization of MC-ZVI NPs were performed using Fourier Transform Infrared spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Dynamic Light Scattering technique (DLS).