Publications by authors named "Hesham Al Saloos"
Article Synopsis
- The study investigates the prevalence of giant aneurysms (GiAn) and Kawasaki disease (KD) research trends across 16 Arab countries over a span of 45 years, revealing a 30% annual growth rate in KD publications.
- It finds that while UAE, KSA, and Egypt produced the majority of KD research, developing nations lag behind, and highlights significant issues like initial misdiagnosis and incomplete cases contributing to an underestimated epidemiology.
- The review emphasizes the need for strategic initiatives to improve KD research and collaboration among Arab countries to better understand and address these health challenges.
Article Synopsis
- TRPM4 is a calcium-activated channel that influences immune cell functions, and mutations in this gene are linked to heart issues but not previously studied for immune problems.
- This study investigates immune dysregulation in a patient with a TRPM4 mutation using various biological techniques, revealing that complete loss of TRPM4 causes heightened vulnerability to bacterial and fungal infections through impaired immune cell migration.
- Findings confirm that TRPM4 is essential for the proper migration of immune cells, suggesting that its dysfunction may lead to increased infection risk.
Transcatheter pulmonary valve implantation (TPVI) is a surgical alternative for correcting dysfunctional right ventricular outflow tract in previously operated patients. MyVal transcatheter heart valve (THV) (Meril Life Sciences, India), a new transcatheter valve designed for aortic position has recently been reported to be implanted in pulmonary position. Myval transcatheter valve were implanted in patients with stenosed dysfunctional conduits, severe regurgitation from transannular patch or dysfunctional surgical pulmonary valves (Bioprosthesis).
View Article and Find Full Text PDFArticle Synopsis
- - Kawasaki disease (KD) is the leading cause of acquired heart disease in children from developed countries, necessitating detailed studies within Arab nations to enhance diagnosis and care.
- - Kawarabi is a collaborative initiative involving North American and Arab experts aimed at improving knowledge and management of KD and similar conditions, primarily initiated during the COVID-19 pandemic's emergence of multisystem inflammatory syndrome in children.
- - Founded in 2021, Kawarabi has identified gaps in awareness and resources concerning KD in Arab countries, and it has organized educational webinars and meetings to promote better understanding of the disease and its long-term outcomes.
Article Synopsis
- - Kawasaki Disease (KD) remains the leading acquired heart disease in children under five, with limited data available from Arab nations, prompting the creation of the KD Arab Initiative (Kawarabi) in 2021 to enhance research and access to care.
- - A survey conducted across thirteen Arab countries revealed that while access to KD care was generally equal in urban and rural areas for over half of the countries surveyed, many rural areas still experienced significant disparities in healthcare access, especially in mid-size cities.
- - The survey indicated a difference in the quality of medical services for KD, with urban children receiving better care, and highlighted that the availability of intravenous immunoglobulin (IVIG) was critically low in rural and mid-size areas,
Background: Transcatheter repair of sinus venosus atrial septal defect (SVASD) has become an alternative option to surgical repair. There are potential significant complications related to stent stability in the superior vena cava (SVC) and potential migration of the stent that need to be addressed. Therefore, the technique is still evolving.
View Article and Find Full Text PDFCongenital heart disease (CHD) is one of the most common forms of birth defects worldwide, with a prevalence of 1-2% in newborns. CHD is a multifactorial disease partially caused by genetic defects, including chromosomal abnormalities and single gene mutations. Here, we describe the Sidra Cardiac Registry, which includes 52 families and a total of 178 individuals, and investigate the genetic etiology of CHD in Qatar.
View Article and Find Full Text PDFBicuspid aortic valve (BAV) is the most common congenital heart disease with a prevalence of 0.5%-1.3% of the population.
View Article and Find Full Text PDFArticle Synopsis
- Studies on Kawasaki disease in Arab countries show limited data, leading to the formation of the KD Arab Initiative (Kawarabi) consortium for collaborative research.
- An anonymous survey among 19 physicians from 12 institutions revealed that while 79% refer to American Heart Association guidelines, there are significant variations in treatment availability, particularly with intravenous immunoglobulin (IVIG).
- The survey found low awareness of Kawasaki disease among the general population (median score 3) but relatively higher knowledge within the medical community (median score 7), highlighting the need for more proactive collaboration and education.
Propionic acidemia is a rare autosomal recessive inborn error of metabolism. It is relatively common in Middle East. Dilated cardiomyopathy is one of the leading causes of morbidity and mortality for patients with propionic acidemia.
View Article and Find Full Text PDFWe sought to determine whether childhood obesity is associated with increased aortic stiffness by measuring the biophysical properties of the aorta in obese children using a noninvasive echocardiographic Doppler method. Increased aortic stiffness is a strong predictor of future cardiovascular events and mortality in adults. Obesity is known to be associated with increased aortic stiffness and arterial disease in adults.
View Article and Find Full Text PDFPurpose: Anthracycline-induced cardiotoxicity (ACT) is a serious adverse drug reaction limiting anthracycline use and causing substantial morbidity and mortality. Our aim was to identify genetic variants associated with ACT in patients treated for childhood cancer.
Patients And Methods: We carried out a study of 2,977 single-nucleotide polymorphisms (SNPs) in 220 key drug biotransformation genes in a discovery cohort of 156 anthracycline-treated children from British Columbia, with replication in a second cohort of 188 children from across Canada and further replication of the top SNP in a third cohort of 96 patients from Amsterdam, the Netherlands.
Two newborn infants presented with acute respiratory distress. In both cases, the left lung was opaque, hyperinflated, and associated with a rightward shift of the mediastinum. A diagnosis of retained fetal fluid secondary to vascular compression of the left bronchus by the ductus arteriosus was made by combining various imaging methods including chest radiograph, computed tomography (CT), and echocardiography.
View Article and Find Full Text PDFWe describe the successful use of the Impella LP 5.0 intracardiac microaxial pump (Abiomed, Danvers, MA) in a 13-year-old boy with fulminant biopsy-proven viral myocarditis. The patient, who previously was in refractory cardiogenic shock despite increasing inotropic and vasopressor support, immediately stabilized after Impella LP 5.
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