Reinforcing β-tricalcium phosphate scaffolds for potential applications in bone tissue engineering: impact of functionalized multi-walled carbon nanotubes.

Beta-tricalcium phosphate (β-TCP) scaffolds manufactured through the foam replication method are widely employed in bone tissue regeneration. The mechanical strength of these scaffolds is a significant challenge, partly due to the rheological properties of the original suspension. Various strategies have been explored to enhance the mechanical properties.

Integrated Fabrication of CuO Nanorod-Decorated Polymer Membranes for the Catalytic Flow-Through Reduction of -Nitrophenol.

We developed a novel method to fabricate copper nanorods in a poly(ether sulfone) (15 wt %) casting solution by a sonochemical reduction of Cu ions with NaBH. The main twist is the addition of ethanol to remove excess NaBH through Cu(0) catalyzed ethanolysis. This enabled the direct use of the resulting copper-containing casting dispersions for membrane preparation by liquid nonsolvent-induced phase separation and led to full utilization of the copper source, generating zero metal waste.

Antioxidant flavonoid-loaded nano-bioactive glass bone paste: apatite formation and flow behavior.

Non-cement pastes in the form of injectable materials have gained considerable attention in non-invasive regenerative medicine. Different osteoconductive bioceramics have been used as the solid phase of these bone pastes. Mesoporous bioactive glass can be used as an alternative bioceramic for paste preparation because of its osteogenic qualities.

Investigating the effect of mesenchymal stem cells on the rate of clinical and pathological improvement of asthmatic lung in mouse model.

Asthma is a pulmonary disease and its pathophysiology includes inflammation, obstruction, edema of the airways, and mucus secretions in the airways. Mesenchymal stem cells (MSCs) are self-renewal that use the therapeutic potential of these cells can be applied as treatments of asthma. In this study, the effect of Mesenchyme stem cells on asthma was investigated.

Design and Manufacture of Bone Cements Based on Calcium Sulfate Hemihydrate and Mg, Sr-Doped Bioactive Glass.

In the present study, a novel composite bone cement based on calcium sulfate hemihydrate (CSH) and Mg, Sr-containing bioactive glass (BG) as solid phase, and solution of chitosan as liquid phase were developed. The phase composition, morphology, setting time, injectability, viscosity, and cellular responses of the composites with various contents of BG (0, 10, 20, and 30 wt.%) were investigated.

Nanocomposite chitosan dressing incorporating polydopamine‑copper Janus nanoparticle.

This research aims to introduce a new wound dressing with antibacterial and anti-inflammatory properties made from chitosan and copper-containing Janus nanoparticles (JNPs). The JNPs were synthesized by attaching copper to PDA nanospheres, which were then embedded in Chitosan at different concentrations. The resulting spherical JNPs had a mean size of 208 ± 96 nm, and EDX mapping showed successful adhesion of Cu ions to PDA nanospheres with a total Cu content of 16.

The effect of green synthesis of TiO nanoparticles/collagen/HA scaffold in bone regeneration: As an animal study.

Background: The bone defects cannot heal by themselves when their range exceeds the critical size defect (CSD). In clinical treatment, significant bone defects are often caused by trauma, developmental deformity, tumour resection and infection.

Objectives: The purpose of this study was to investigate the effect of green synthesis of TiO from propolis extract/collagen/HA (Hydroxyapatite) scaffolds on bone regeneration in rats.

L-Theanine Improves Locomotor Function in a Model of Multiple Sclerosis Mice.

This study designed to investigate the protective effects of L-theanine on experimental Multiple sclerosis in mice. Frothy Male C57BL/6 mice were allocated into 4 experimental groups: control no treatment received a regular chew pellet, and the cuprizone (CPZ) group received a standard chew pellet containing 0.2% (w/w) CPZ.

Controlled release of a non-steroidal anti-inflammatory drug from a photocurable polymeric calcium phosphate cement.

In this research, a photocurable composite based on tetracalcuim phosphate ceramic and, hydroxyethyl methacrylate-modified poly(acrylic-maleic acid) was developed and studied as a potential drug delivery system for bone defects. Different concentrations (5, 10 and 20 wt. %) of a non-steroidal anti-inflammatory drug, Indomethacin, were loaded on to the composite and its release behavior was investigated in phosphate buffered solution during 504 h.

Reinforcement of Calcium Phosphate Cement with Hybrid Silk Fibroin/Kappa-Carrageenan Nanofibers.

Calcium phosphate cements (CPCs) offer a promising solution for treating bone defects due to their osteoconductive, injectable, biocompatible, and bone replacement properties. However, their brittle nature restricts their utilization to non-load-bearing applications. In this study, the impact of hybrid silk fibroin (SF) and kappa-carrageenan (k-CG) nanofibers as reinforcements in CPC was investigated.

Assessment of tricalcium phosphate/titanium dioxide (TCP/TiO2) nanocomposite scaffold compared with bone autograft and hydroxyapatite (HA) on the healing of segmental femur bone defect in rabbits.

Bone healing is a tissue process after a surgical operation. Many formulated materials have been designed for improving these procedures. The purpose of this study was to evaluate the effectiveness of nanocomposite tricalcium phosphate scaffolds combined with Titanium dioxide scaffold (TCP/TiO2) for femoral defects regeneration in rabbits.

The Effect of Gracilaria Corticata and Scenedesmus Acuminates Extract Mixture on the Healing of Wounds Contaminated with Staphylococcus in the Rat Model.

Introduction: Wound healing processes are dependent on the severity of the trauma, invasion of opportunistic microorganisms, and inflammatory, immunological, and metabolic responses. We tried to show the ability of algae to inhibit wound infection, which can lead to proper wound healing.

Methods: Eighty rats were housed according to laboratory animal care protocols and divided into four groups at each operating time.

The controlled release, bioactivity and osteogenic gene expression of Quercetin-loaded gelatin/tragacanth/ nano-hydroxyapatite bone tissue engineering scaffold.

In this study, a Gelatin/Tragacanth/Nano-hydroxyapatite scaffold was fabricated freeze-drying method. A highly porous scaffold with an average pore diameter of 142 µm and porosity of 86% was found by the micro-computed tomography. The mean compressive strength of the scaffold was about 1.

Electrospun Silk Fibroin/-Carrageenan Hybrid Nanofibers with Enhanced Osteogenic Properties for Bone Regeneration Applications.

In this study, a novel nanofibrous hybrid scaffold based on silk fibroin (SF) and different weight ratios of -carrageenan (-CG) (1, 3, and 5 mg of -CG in 1 mL of 12 wt% SF solution) was prepared using electrospinning and genipin (GP) as a crosslinker. The presence of -CG in SF nanofibers was analyzed and confirmed using Fourier transform infrared spectroscopy (FTIR). In addition, X-ray diffraction (XRD) analysis confirmed that GP could cause SF conformation to shift from random coils or α-helices to β-sheets and thereby facilitate a more crystalline and stable structure.

Protective Effects of Phoenixin-14 Peptide in the Indomethacin-Induced Duodenal Ulcer: An Experimental Study.

Phoenixin-14‎ (PNX‎-14‎) is a newly identified neuropeptide with potential anti-inflammatory effects in the gastrointestinal tract. In this study, we evaluated the protective effect of PNX-14 against the formation of experimental indomethacin (IND)-induced duodenal ulcer. Thirty-two‎ male Sprague-Dawley rats were randomly assigned to the four following study groups: (1) negative control (2) IND (7.

Wound closure, angiogenesis and antibacterial behaviors of tetracalcium phosphate/hydroxyethyl cellulose/hyaluronic acid/gelatin composite dermal scaffolds.

Polymeric and tetracalcium phosphate (TTCP)-containing polymeric scaffolds were fabricated using a freeze-drying technique, with a homogenous solution of hydroxyethyl cellulose (HEC)/hyaluronic acid (HA)/gelatin (G) or suspension of 15 or 20% TTCP) particles in HEC/HA/G solution. The morphology, phase composition, chemical bands, and swelling behavior of the scaffold were determined. fibroblast cell viability and migration potential of the scaffolds were determined by MTT, live/dead staining, and scratch assay for wound healing.

Bioorthogonal hydroxyethyl cellulose-based scaffold crosslinked via click chemistry for cartilage tissue engineering applications.

In this study, azide and alkyne moieties were introduced to the structure of citric acid-modified hydroxyethyl cellulose (HEC) and then through a bioorthogonal click chemistry method: Strain-promoted azide-alkyne cycloaddition, a novel crosslinked HEC scaffold (click sample) was obtained. Chemical modifications and successful crosslinking of the samples were assessed with FTIR and H NMR spectroscopy. Lyophilized samples exhibited a porous interconnected microarchitecture with desirable features for commensurate cartilage tissue engineering applications.

evaluation of curcumin-loaded chitosan-coated hydroxyapatite nanocarriers as a potential system for effective treatment of cancer.

Nanotechnology has many potential applications in cancer treatment. For example, nano-drug delivery systems (NDDS) with high bioavailability, biodegradability, and biocompatibility have been developed, in order to increase the therapeutic effects of anticancer drugs. Among these NDDS, high-performance hydroxyapatite (HA) nanoparticles are rapidly advancing in the targeted cancer treatment due to their numerous benefits.

The synergistic effects of SrF nanoparticles, YSZ nanoparticles, and poly-ε-l-lysin on physicomechanical, ion release, and antibacterial-cellular behavior of the flowable dental composites.

Resin-based pit-and-fissure sealants (flowable resin composites) were formulated using bisphenol-A-glycerolatedimethacrylate (Bis-GMA)-triethylene glycol dimethacrylate-(TEGDMA)-diurethanedimethacrylate (UDMA) mixed monomers and multiple fillers, including synthetic strontium fluoride (SrF) nanoparticles as a fluoride-releasing and antibacterial agent, yttria-stabilized zirconia (YSZ) nanoparticles as an auxiliary filler, and poly-ε-l-lysin (ε-PL) as an auxiliary antibacterial agent. Based on the physical, mechanical and initial antibacterial properties, the formulated nano-sealant containing 5 wt% SrF, 5 wt% YSZ and 0.5 wt% ε-PL was selected as the optimal specimen and examined for ion release and cytotoxicity.

Creep behavior of Biodegradable Triple-component Nanocomposites Based on PLA/PCL/bioactive Glass for ACL Interference Screws.

Background: Short-time creep behaviorfor aseries of biodegradable nanocomposites, which areused as implantable devices inthe body, is a crucial factor.The present study aimed to investigate the effect of bioactive glass nanoparticles (BGn) on creep and creep-recovery behaviors of polylactic acid/polycaprolactone (PLA/PCL) blends at different given loads and different applied temperatures.

Methods: A series of biodegradable nanocomposites consisted of PLA/PCL blends (comprising 80 parts PLA and 20 parts PCL) with different amounts of modified-BGn (m-BGn) fillers were prepared using the evaporated solvent casting technique.

Evaluation of Influence of Zeolite/Collagen Nanocomposite (ZC) and Hydroxyapatite (HA) on Bone Healing: A Study on Rabbits.

Bone healing is still a great challenge in orthopedic surgery and clinical practice. There is a dearth of research investigating the effect of Zeolite/Collagen (ZC) nanocomposite on bone regeneration. In the present study, a critical segmental defect of the rabbit femur was repaired using defects in femurs repaired by ZC nanocomposite, and the effects were examined histologically.

Histopathology and Histomorphological Study of Wound Healing Using Clove Extract Nanofibers (Eugenol) Compared to Zinc Oxide Nanofibers on the Skin of Rats.

In order to evaluate the healing effect of eugenol and other nanofibers, 100 male Wistar rats (200±10 g) were used with 14-15 weeks of age in this study. All of the male rats were transferred in the standard cages under controlled exposure conditions in a 12:12 h light/dark cycle with a constant temperature about 22±2 oC. In addition, the male rats were fed with pellets.

Effect of N-acetyl-cysteine nanoparticles on intra-abdominal adhesion after laparotomy in rats.

Postoperative adhesion (POA) is a common and well-known complication with an estimated risk of 50-100%. The antioxidant effect of n-acetyl-cysteine (NAC) can increase intracellular glutathione levels, thereby reducing adhesion. This study was conducted to compare the outcomes of NAC nanoparticles (Nano-NAC) on intra-abdominal adhesion (IAA) after laparotomy in rat.

The physical, mechanical, and biological properties of silk fibroin/chitosan/reduced graphene oxide composite membranes for guided bone regeneration.

In this study, blends of chitosan (CS)/silk fibroin (SF) and reduced graphene oxide (rGO) as guided bone regeneration membranes were fabricated by solvent casting method and their architectural features, hydrophilicity, porosity, swelling, degradation, and mechanical properties were investigated. The influence of CS, SF, and rGO on osteoblasts spreading and attachment was also determined by scanning electron microscopy (SEM) images and DAPI (4', 6-diamidoino-2-phenylindole) staining assay. The osteogenic differentiation was determined by the alizarin red staining and alkaline phosphatase activity.