Publications by authors named "Herwig F Jansen"
Background: This study was conducted to determine the efficacy of the antimalarial artemisinin-based combination therapy (ACT) artesunate +sulfamethoxypyrazine/pyrimethamine (As+SMP), administered in doses used for malaria, to treat Schistosoma haematobium in school aged children.
Methodology/principal Findings: The study was conducted in Djalakorodji, a peri-urban area of Bamako, Mali, using a double blind setup in which As+SMP was compared with praziquantel (PZQ). Urine samples were examined for Schistosoma haematobium on days -1, 0, 28 and 29.
Article Synopsis
- - The study compared the effectiveness of artesunate-sulfamethoxypyrazine-pyrimethamine to artemether-lumefantrine in treating uncomplicated Plasmodium falciparum malaria in Mali during 2003 and 2004.
- - Results indicated a higher cure rate for artesunate-sulfamethoxypyrazine-pyrimethamine (98.7%) compared to artemether-lumefantrine (89.6%), with both treatments showing high efficacy post-re-infection correction.
- - Both treatments were well-tolerated, with no serious adverse events reported, but artesunate-sulfamethoxypyrazine-pyrimethamine also helped prevent new infections effectively.*