[Solid tumor lysis syndrome: an entity that should not be neglected].

Tumor lysis syndrome is a metabolic emergency resulting from a massive destruction of cancer cells. This is often associated with hematological malignancies, such as non-Hodgkin's lymphoma and acute leukemia, but the incidence tends to increase for solid tumors with the development of oncological treatments. Due to a poor prognosis, it is essential to recognize this syndrome early.

Fatal fulminant hepatitis in a patient taking abiraterone acetate: a case report.

Abiraterone acetate is a steroidal inhibitor of cytochrome P450 17A1 indicated in the treatment of metastatic prostate cancer. This report examines the case of a 66-year-old patient diagnosed with prostate adenocarcinoma that had metastasized to the bones and lymph nodes. Treatment with abiraterone acetate and corticosteroid co-administration as well as LH-RH analog hormone therapy was initiated.

[Intensive care unit treatment for patients suffering from COVID-19: The second wave Neuchâtel experience].

Between mid-October 2020 and mid-January 2021, during the second wave of COVID-19 pandemia, 125 patients have been admitted in the intensive care units of Neuchâtel network hospitals. To manage this flow, the bed capacity of intensive care unit increased by 240%. Each patient received corticosteroids, an increased prophylactic anticoagulation and an antibiotic.

Development of the AL-O-A Score for Delirium Screening in Acute Internal Medicine: a Monocentric Prospective Study.

Background: Delirium occurs frequently in acute internal medicine wards and may worsen the patient's prognosis; it deserves a fast, systematic screening tool.

Objective: Develop a delirium screening score for inpatients admitted to acute internal medicine wards.

Design: A monocentric prospective study between November 2019 and January 2020.

Acute cytokine release syndrome after a first dose of pembrolizumab as second-line treatment for metastatic, programmed death-ligand 1-positive, non-small-cell lung cancer.

Introduction: The use of programmed death-ligand 1 (PD-L1) checkpoint inhibitor therapy is expanding, although its adverse effects are not completely known. We report on a rare case of acute cytokine release syndrome related to pembrolizumab use in a patient with lung cancer.

Case Report: A 79-year-old man with metastatic, PD-L1-positive, non-small-cell lung cancer developed a febrile condition associated with a systemic inflammatory response syndrome and suffered haemodynamic compromise four hours after the first intravenous administration of pembrolizumab.

[Intensive care unit treatment for patients suffering from COVID-19: the Neuchâtel experience].

SARS-CoV-2 appeared in Switzerland in February 2020 and reached Neuchâtel in March. During 2 months, 43 patients were admitted in the intensive care unit. 55% of ICU admitted patients received mechanical ventilation, 66% of which in prone position.

Rare case of bilateral pleural effusion caused by pancreaticopleural fistula.

A 51-year-old man presented with dyspnoea and basithoracic pain. Chest X-ray revealed bilateral pleural effusion, which was managed by bilateral chest drain placement. The pleural fluid analysis showed elevated lipase.

[Adult severe community-acquired pneumonia: from diagnosis to intensive care].

Severe community-acquired pneumonia is defined as a pneumonia acquired in an extra-hospital setting requiring intensive care. Clinical scores such as the ATS modified rule can help the clinician to recognize quickly the patients needing ICU. Evidence based interventions decreasing mortality consist of rapid administration of antibiotics, by probably privileging an association containing a macrolide, as well as fast and specialized care of shock and respiratory failure.

Life-threatening pulmonary embolism associated with a thrombus straddling a patent foramen ovale: report of a case.

Background And Aim: A biatrial thrombus straddling a patent foramen ovale (PFO) is rare. The optimal management is controversial. This report offers an additional report and brief review of the literature.

Toxic epidermal necrolysis after topical intranasal application of mupirocin.

We describe a case of toxic epidermal necrolysis after intranasal application of mupirocin in a 76-year-old woman. The drug was given for eradication of methicillin-resistant Staphylococcus aureus.