[Solid tumor lysis syndrome: an entity that should not be neglected].

Tumor lysis syndrome is a metabolic emergency resulting from a massive destruction of cancer cells. This is often associated with hematological malignancies, such as non-Hodgkin's lymphoma and acute leukemia, but the incidence tends to increase for solid tumors with the development of oncological treatments. Due to a poor prognosis, it is essential to recognize this syndrome early.

[Intensive care unit treatment for patients suffering from COVID-19: The second wave Neuchâtel experience].

Between mid-October 2020 and mid-January 2021, during the second wave of COVID-19 pandemia, 125 patients have been admitted in the intensive care units of Neuchâtel network hospitals. To manage this flow, the bed capacity of intensive care unit increased by 240%. Each patient received corticosteroids, an increased prophylactic anticoagulation and an antibiotic.

Acute cytokine release syndrome after a first dose of pembrolizumab as second-line treatment for metastatic, programmed death-ligand 1-positive, non-small-cell lung cancer.

Introduction: The use of programmed death-ligand 1 (PD-L1) checkpoint inhibitor therapy is expanding, although its adverse effects are not completely known. We report on a rare case of acute cytokine release syndrome related to pembrolizumab use in a patient with lung cancer.

Case Report: A 79-year-old man with metastatic, PD-L1-positive, non-small-cell lung cancer developed a febrile condition associated with a systemic inflammatory response syndrome and suffered haemodynamic compromise four hours after the first intravenous administration of pembrolizumab.

[Intensive care unit treatment for patients suffering from COVID-19: the Neuchâtel experience].

SARS-CoV-2 appeared in Switzerland in February 2020 and reached Neuchâtel in March. During 2 months, 43 patients were admitted in the intensive care unit. 55% of ICU admitted patients received mechanical ventilation, 66% of which in prone position.

Life-threatening pulmonary embolism associated with a thrombus straddling a patent foramen ovale: report of a case.

Background And Aim: A biatrial thrombus straddling a patent foramen ovale (PFO) is rare. The optimal management is controversial. This report offers an additional report and brief review of the literature.