Publications by authors named "Herve Nordmann"
Low-grade inflammation is a characteristic of the obese state, and adipose tissue releases many inflammatory mediators. The source of these mediators within adipose tissue is not clear, but infiltrating macrophages seem to be especially important, although adipocytes themselves play a role. Obese people have higher circulating concentrations of many inflammatory markers than lean people do, and these are believed to play a role in causing insulin resistance and other metabolic disturbances.
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- The paper showcases the BRAFO-tiered method for benefit-risk assessments applied to various case studies related to dietary interventions.
- It tests this approach across five specific examples, including food fortification and macronutrient replacements, using existing evaluations rather than conducting new ones.
- Results varied, indicating scenarios ranging from halting the assessment due to unclear benefit-risk questions to progressing through detailed calculations.