Publications by authors named "Herve Dechaud"
Article Synopsis
- The study reviews the surgical treatment of endometriosis in specialized French centers, analyzing data from 361 patients over 21 hospitals between 2015 and 2017.
- Most patients had severe stages of endometriosis, with common procedures being uterosacral ligament resection and rectal surgery; around 60% received antiadhesion treatments.
- Post-surgery, a high satisfaction rate (95%) was noted among patients, with low major complication risks under 10%.
Article Synopsis
- The study examines how an early increase in serum progesterone levels on the day of hCG administration affects endometrial gene expression in patients undergoing IVF.
- It was found that patients with elevated progesterone (>1.5 ng/mL) displayed a different gene expression shift from the prereceptive to the receptive stage of the endometrium, indicating faster endometrial maturation.
- Despite these changes in gene expression, the overall endometrial receptivity remained similar between patients with normal and elevated progesterone levels.
Article Synopsis
- Successful pregnancy relies on dynamic early embryonic development, particularly the trophoblast cell lineage, but there's limited molecular data on these processes.
- Researchers compared RNA transcripts from human trophectoderm (TE) cells at day 5 of blastocyst development with those from day 3 embryos, finding 2,196 TE-specific transcripts and 1,714 up-regulated in day 3 embryos, including key genes linked to TE functions and stemness.
- The study identifies important genes involved in processes like trophoblast invasion, chromatin remodeling, and steroid metabolism, which could be used as biomarkers for selecting viable embryos in fertility treatments.
Article Synopsis
- Endometriosis affects 10-15% of women of reproductive age and is marked by painful symptoms, with certain cytokines in peritoneal fluid (PF) correlating to disease severity.
- A study used the Bio-Plex platform to compare cytokine levels in the PF of women with and without endometriosis across different menstrual phases (proliferative and secretory).
- Results showed that IL-6, IL-18, and MCP-1 were elevated in women with endometriosis and remained consistent regardless of the menstrual cycle, suggesting these cytokines could be potential biomarkers for the disease.
Article Synopsis
- The study investigates how in vitro maturation (IVM) affects the gene expression in cumulus cells (CCs) associated with oocytes, comparing CCs from in vivo and in vitro matured oocytes at different stages of nuclear maturation.
- Researchers analyzed CCs from patients with polycystic ovary syndrome (PCOS) and normal responders, using microarray technology to reveal differences in gene expression profiles.
- Results show that IVM leads to down-regulation of genes important for cumulus expansion and oocyte maturation, suggesting that IVM may result in an incomplete maturation process and highlighting the need for improved IVM conditions.
Insights into human endometrial receptivity from transcriptomic and proteomic data.
Reprod Biomed Online
January 2012
Article Synopsis
- Understanding endometrial receptivity is essential in assisted reproductive technology since many implantation failures are linked to its abnormalities.
- Recent advancements in omics technologies have allowed researchers to identify molecular signatures and specific biomarkers that characterize a receptive endometrium.
- This review focuses on how analyzing gene and protein expression changes between different stages can lead to better strategies for assessing endometrial receptivity and understanding the impact of stimulation protocols on clinical outcomes.
Article Synopsis
- The study focuses on the communication between oocytes and cumulus cells (CCs), which is essential for the oocyte's development and quality.
- Researchers analyzed the gene expression in human CCs from different stages of oocyte maturity using advanced microarray technology.
- The findings showed distinct gene expression patterns in CCs from mature oocytes, which could help predict oocyte quality and improve reproductive outcomes.
Article Synopsis
- * BCL2 family proteins are key regulators of cell death and survival, with most research focusing on the opposing roles of BCL2 (survival) and BAX (pro-apoptotic), alongside new candidate genes linked to embryonic viability and apoptosis.
- * Understanding how BCL2 family proteins are distributed during oocyte maturation and early embryonic development could enhance fertility diagnostics and assisted reproductive technologies, particularly in cases of infertility linked to gene expression and protein distribution issues.
Article Synopsis
- The study investigates how certain antihypertensive medications used to treat preeclampsia affect endothelin-1 (ET-1) induced contractions in human uterine arteries.
- Only dihydropyridines among the tested antihypertensive drugs were effective in partially blocking the contractile response to ET-1, while others had no impact.
- The research concludes that existing treatments do not fully reverse ET-1 induced contractions, suggesting a potential role for dihydropyridines in improving placental blood flow.
Article Synopsis
- Scientists studied how human embryos develop in the first week and how this knowledge can help improve in vitro fertilization (IVF).
- They looked at many research articles and data about human eggs, embryos, and stem cells to see what genes were active during this time.
- Their findings showed that specific genes affect early development, and understanding these could help choose the best embryos for IVF without hurting them.
Members of the phylum Synergistetes have been demonstrated in several environmental ecosystems and mammalian microflorae by culture-independent methods. In the past few years, the clinical relevance of some uncultivated phylotypes has been demonstrated in endodontic infections, and uncultured Synergistetes have been demonstrated in human mouth, gut and skin microbiota. However, Synergistetes are rarely cultured from human samples, and only 17 isolates are currently reported.
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- * Endometrial biopsies were taken from normal-responder patients during different stages of IVF, and gene expression was analyzed using DNA microarrays to assess receptivity changes.
- * Findings reveal that both GnRH protocols affect endometrial receptivity, with notable differences in chemokines and growth factors, and the GnRH antagonist protocol resembles natural cycle receptivity more closely than the GnRH agonist protocol.
Article Synopsis
- This review assesses the impact of severe endometriosis on IVF outcomes and explores complications, ovarian stimulation protocols, and the progression of endometrial conditions during treatment.
- IVF is shown to be an effective infertility treatment for severe endometriosis patients, comparable in success to those without the condition, but carries risks, especially concerning ovarian function.
- Early initiation of IVF with tailored protocols and thorough patient education about retrieval risks is recommended to optimize treatment results.
Total fertilization failure and molecular abnormalities in metaphase II oocytes.
Reprod Biomed Online
December 2008
Article Synopsis
- Total fertilization failures (TFF) in IVF via ICSI are rare but raise concerns regarding management when no male factor is involved.
- This study aimed to identify molecular abnormalities in eggs from a 30-year-old patient with repeated TFF by comparing mRNA expression profiles of her oocytes to those of fertile control patients.
- Findings indicated altered gene expression in crucial biological processes within the oocytes, suggesting that high-quality-looking eggs may still have hidden molecular issues, which could lead to more informed clinical management and potential alternative treatments.
Article Synopsis
- Transvaginal ultrasonography is used in IVF programs to non-invasively assess uterine receptivity, aiming to improve pregnancy prediction.
- A study involving 124 patients analyzed various ultrasonographic factors, including endometrial thickness and blood flow, during key IVF stages.
- The best predictors of pregnancy involved a combination of end-diastolic blood flow, endometrial pattern, and thickness, achieving around 81% sensitivity and specificity, particularly effective on the day of HCG administration.
Identifying new human oocyte marker genes: a microarray approach.
Reprod Biomed Online
February 2007
Article Synopsis
- Classical IVF techniques face challenges with low embryo implantation and pregnancy rates, largely due to insufficient criteria for selecting viable embryos.
- Recent research suggests that certain gene expression levels can serve as objective markers to assess oocyte and embryo quality.
- Microarray technology has revealed a broader range of potential gene markers, identifying new regulators like BARD1 and BUB1B that are involved in the maturation of oocytes.
Article Synopsis
- A comparative study was conducted on protein expression in human cumulus cells from oocytes subjected to two different ovarian stimulation protocols for classical IVF, using high-resolution techniques to analyze the proteins.* -
- The findings revealed that hormonal treatment notably impacts the protein expression profile of cumulus cells, even when comparing oocytes from the same patient.* -
- Significant differences were observed in protein patterns between different patients, suggesting that cumulus protein synthesis may correlate with oocyte maturity and fertility outcomes.*
Article Synopsis
- Researchers studied the differences in gene expression between immature and mature human oocytes and surrounding cumulus cells to better understand oocyte maturation.
- They discovered a substantial number of genes that were up-regulated during oocyte maturation, including key growth factors and transcription factors previously not reported in this context, as well as signaling genes in cumulus cells.
- The findings enhance our understanding of oocyte biology and suggest new markers for identifying viable oocytes, with potential implications for granulosa cell tumors.
Article Synopsis
- Cardiac arrest due to postpartum hemorrhage may not respond well to traditional resuscitation techniques, prompting consideration of alternative methods like sternotomy or ECMO.
- A case study detailed a woman who experienced severe hemorrhage after a cesarean delivery, leading to cardiac arrest that did not improve for two hours before ECMO was started.
- The successful use of ECMO suggests that aggressive mechanical support may be crucial for young obstetric patients facing serious circulatory issues.
Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer.
Eur J Obstet Gynecol Reprod Biol
July 2006
Article Synopsis
- The study aimed to evaluate how body mass index (BMI) affects the outcomes of in vitro fertilization (IVF) in infertile patients.
- A total of 573 patients were analyzed across four BMI categories during IVF cycles, revealing that obese patients required a higher dose of r-FSH for follicular development.
- Despite the increased medication dosage for obese patients, the study found that obesity did not negatively impact the overall success rates of IVF, such as implantation or pregnancy rates.
Article Synopsis
- A case was reported of a child with renal issues due to severe low amniotic fluid (anhydramnios) linked to maternal use of the medication valsartan during the first 28 weeks of pregnancy.
- The mother, who had hypertension, was taking valsartan alongside other medications; after stopping valsartan, the child's renal condition improved, leading to only mild chronic renal insufficiency by age 2.5 years.
- Research suggests that exposure to angiotensin II receptor antagonists like valsartan in pregnancy can cause serious fetal complications, and these medications should generally be avoided to prevent potential harm to the fetus.
Article Synopsis
- - A 28-year-old woman experienced secondary amenorrhoea due to an arteriovenous malformation (AVM), with no other symptoms besides the absence of menstrual cycles.
- - Imaging revealed the AVM, and it was successfully treated with endovascular embolization, resulting in partial thrombosis of the lesion.
- - Two months after the treatment, the woman regained her menstrual cycles, suggesting that the AVM may have been diverting blood from the endometrium, causing the amenorrhoea.