Anuria in childhood due to bilateral urolithiasis. A report of four cases.

Four children with anuria due to occlusion of both ureters by calculi are presented. A plain film of the abdomen revealed faintly radiopaque urinary calculi bilaterally in three patients. In the fourth case, one calculus was visualized in the right ureter, but further contralateral exploration showed an obstructing ureteral calculus in the left ureter as well.

Radiological findings of the urinary tract in hypospadias: a report of 110 cases.

One hundred and ten patients with hypospadias underwent excretory urography and micturating cysto-urethrography before surgical correction. Urographic studies revealed abnormalities in 50 patients (45%), mainly anomalies of ascent and rotation of the kidneys. None of these patients required corrective surgery.

Symphalangism, short stature, skeletal anomalies, and accessory testis: a new malformation syndrome.

A 17-year-old Jewish Sephardi male is described with symphalangism, short stature, multiple skeletal anomalies, and an accessory testis, which appears to be a new malformation syndrome of possible genetic aetiology.

Transfer of bromocriptine across the blood-brain barrier in man.

The transfer of 14C-bromocriptine across the blood-brain barrier was studied in 10 patients using the double indicator single injection method. The extraction (E) of bromocriptine was 8 % (quartiles: 6 and 14 %). Based on the results the cerebral uptake velocity of bromocriptine was calculated assuming constant arterial drug concentration.

The effect of propranolol on cerebral oxygen consumption and blood flow in the rat: measurements during normocapnia and hypercapnia.

The cerebral blood flow (CBF) and cerebral oxygen consumption (CMRO2) in the rat during normocapnia and hypercapnia were investigated by means of the intraarterial 133Xenon injection technique; measurements were performed during normocapnia and hypercapnia and the effect of propranolol upon CBF and CMRO2 was studied. The CBF technique applied to rat yield reliable results even in high flow situations. A steady state period of only 10--15 s is all that is necessary to obtain the initial slope of the 133Xenon clearance curve from which CBF is calculated and measurements may be repeated within minutes.

Blood-brain barrier permeability during shortlasting intravascular hyperosmolality.

Blood-brain barrier permeability for 24Na+ and 36Cl- ions and for 3HOH was studied during isoosmolality and during shortlasting intravascular hyperosmolality in twenty-five patients using the double indicatir single injection method. Hyperosmolality was induced by a rapid injection into the internal carotid artery of 8 ml of one of the following hypertonic solutions: 5% saline, 25% mannitol or a contrast medium of the metrizoat group (Isopaque-amine 280). The extractions of the small sodium and chloride ions remained unchanged and essentially zero indicating that 'opening' of the blood-brain barrier did not occur.

Cystourethrography as an aid in the evaluation of hypospadias and its complications.

We report the use of micturating cystourethrography to demonstrate complications of the urethra in hypospadias. We recommend MCU to evaluate hypospadias, both before and after the surgical repair.

Hodgkin's disease of the lung.

The clinical and radiological findings in 16 patients with Hodgkin's disease involving the lung are reviewed. Lung involvement was evident at initial presentation in 11 patients and appeared during the course of the disease in five patients. All the patients had hilar as well as mediastinal lymphadenopathy; most of them--14 of 16--had the nodular sclerosis type of the disease.

Unilateral vascular plethora--a sign in advanced unilateral basal bronchiectasis.

Unilateral basal bronchiectasis results in a regional high vascular pressure and the flow of blood is thereby diverted to the uninvolved portion of the lung through bronchopulmonary anastomoses. Unilateral plethora of the upper lobe vessels in significant basal bronchiectasis of the same lung constitutes an important additional sign in the recognition of bronchiectasis on the plain chest radiograph. Attention is drawn to the fact that this will not occur if the adjacent lung is compromised by a related or unrelated disease process.

Isoproterenol and propranolol: ability to cross the blood-brain barrier and effects on cerebral circulation in man.

Using the "double indicator" technique the ability of 3H-isoproterenol and 14C-propranolol to cross the blood-brain barrier was studied in man. In 3 subjects extraction of isoproterenol was 3.8% in a single passage and the PS product was 2.

Glycocinnamoylspermidines, a new class of antibiotics. II. Isolation, physiocochemical and biological properties of LL-BM123beta, gamma1 and gamma2.

LL-BM123beta, gamma1 and gamma2 are three new antibiotics produced by fermentation of an unidentified species of Nocardia. These strongly basic, water soluble compounds were isolated from the culture filtrate by CM-Sephadex ion-exchange and carbon chromatography. All three antibiotics are active against both gram-positive and gram-negative bacteria.

Fused labia. Clinical and radiological findings.

The clinical and radiological findings in fused labia are described. Some of the patients were asymptomatic. The others were referred because of a suspicion of urinary infection.

Increased permeability to horseradish peroxidase across cerebral vessels, evoked by electrically induced seizures in the rat.

Under normal conditions a slight vesicular transfer of intravenously injected horseradish peroxidase (HRP) occurs across the endothelium of cerebral vessels, especially short segments of arterioles. The vesicular transport can be notably increased by chemically induced acute hypertension. In the present investigation 4 groups of animals received HRP, and the permeability of the cerebral endothelium was studied semimacroscopically, light microscopically and electron microscopically.

Extramedullary hematopoiesis with multiple tumor-simulating mediastinal masses in a patient with beta-thalassemia intermedia.

A patient with beta-thalassemia intermedia with massive extramedullary hematopoiesis in the mediastinum is presented. These masses, which simulate tumors, are usually asymptomatic only rarely causing spinal cord compression. The histologic examination showed that they consist of hematopoietic tissue.

Acute hypertension causing blood-brain barrier breakdown during epileptic seizures.

The influence of shortlasting (less than 1 min) epileptic seizures on the permeability to protein of the blood-brain barrier (BBB) was studied in rats. The protein tracer, horseradish peroxidase (HRP) was used as marker substance. Monitoring arterial blood pressure (BP) and electroencephalogramme (EEG) seizures were induced electrically after HRP was given intravenously.

Renal vein thrombosis in a newborn: a case report with emphasis on pathological and radiological features.

A case of renal vein thrombosis in a newborn is presented. Trauma during pregnancy is suggested as an etiological factor. In contradistinction to most cases reported the newborn showed no signs of acute illness except for a palpable abdominal mass.

A unique combination of congenital genitourinary anomalies in a child.

A case of solitary crossed renal ectopia with concomitant, severe vesicoureteral reflux and a rudimentary ipsilateral ectopic ureter draining into the vas deferens is presented. In addition to these anomalies the patient had complete urethral duplication and right cryptorchidism, as well as right congenital dislocation of the hip. To our knowledge this is the first such case to be documented in the medical literature.