Publications by authors named "Hersh A"

Article Synopsis
  • This study examined how the volume of operative vaginal deliveries (OVDs) at hospitals in California from 2008 to 2020 affects adverse outcomes for both birthing individuals and newborns.
  • It categorized hospital OVD volume into low (less than 5.2%), medium (5.2%-7.4%), and high (7.4% or more), finding that lower volume hospitals had a higher incidence of complications such as obstetric anal sphincter injuries and adverse neonatal outcomes.
  • The research utilized extensive data from birth certificates and hospital records to analyze trends, highlighting the need for improvements in obstetric care based on hospital performance.
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Background: Emergency department (ED) use is common among patients with Medicaid insurance during pregnancy. However, it is unknown how ED utilization differs among those with different types of Medicaid such as Emergency Medicaid, with which access to outpatient care is more restricted.

Objective: We sought to compare differences in ED use during between pregnant persons with Emergency Medicaid and Traditional Medicaid and pregnancy outcomes by ED utilization.

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Objective: There is a paucity of high-quality return-to-play (RTP) data following treatment of cervical spine injuries in contact sports. In this study, the authors gathered insights from National Football League (NFL) team spine surgeon consultants to highlight current practices in treating cervical spine injuries and report decision-making regarding RTP in professional American football players.

Methods: A cross-sectional, online survey was distributed to all NFL consulting physicians specializing in the management of spine injuries.

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  • The study aimed to adapt the Inappropriate Diagnosis of UTI (ID-UTI) measure for use in Critical Access Hospitals (CAHs), assessing its feasibility, validity, and reliability.
  • Only 40% of participating CAHs met the target for case submissions, with the ID-UTI metric showing high specificity (100%) but low sensitivity (48.5%) compared to physician reviews.
  • While the adapted measure was reliable (93% agreement), challenges remain in ensuring its consistent application across CAHs.
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A survey of pediatric infectious diseases clinicians from 49 children's hospitals demonstrated variability across institutions in the treatment of epidural empyema from sinus extension, including antibiotic route, selection, and impact of neuroimaging on determining duration of therapy.

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Objective: Traditional management of patients with metastatic epidural spinal cord compression (MESCC) consists of radiotherapy (RT) with or without surgical decompression. With extensive literature and the introduction of clinical frameworks, such as the neurologic, oncologic, mechanical, and systemic criteria and the epidural spinal cord compression scale, progress has been made in refining the appropriate treatment regimen. In this review, we analyze the existing literature to identify the consensus frameworks and the remaining gaps in clinical knowledge.

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Objective: To determine whether differences exist in antibiotic prescribing for respiratory infections in pediatric urgent cares (PUCs) by patient race/ethnicity, insurance, and language.

Design: Multi-center cohort study.

Setting: Nine organizations (92 locations) from 22 states and Washington, DC.

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Objective: The authors investigated the predictors of cost of admission (CoA) for robot-assisted pedicle screw placement to assess the value of robotic systems in spine operations.

Methods: Demographic, operative, and postoperative variables were retrospectively collected from 506 patients undergoing robot-assisted spine surgery utilizing the ExcelsiusGPS robot at two high-volume tertiary care centers from 2017 to 2023. Perioperative parameters were evaluated against total hospital admission cost utilizing the Kruskal-Wallis and Wilcoxon rank-sum tests followed by multivariable linear regression.

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Background: Robotic platforms have increased in sophistication for pedicle screw placement. Here, we review our institutional experience using ExcelsiusGPS to assess the accuracy rate of pedicle screw placement throughout the spine and characterize predictors of placement inaccuracy.

Study Design: Retrospective cohort study.

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Introduction: There remains uncertainty about whether transitioning to oral antibiotic therapy is appropriate for the management of children with methicillin-resistant Staphylococcus aureus (MRSA) bacteremic osteomyelitis. We compared clinical outcomes for children with MRSA osteomyelitis with associated bacteremia who were transitioned to discharge oral antibiotic therapy to those discharged on outpatient parenteral antibiotic therapy (OPAT).

Methods: We performed a retrospective, multicenter, cohort study of children ≤ 18 years hospitalized with MRSA bacteremic osteomyelitis across four children's hospitals from 2007 to 2018 discharged on oral antibiotic therapy versus OPAT.

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Background: Asymptomatic bacteriuria (ASB) treatment is a common form of antibiotic overuse and diagnostic error. Antibiotic stewardship using the inappropriate diagnosis of urinary tract infection (ID-UTI) measure has reduced ASB treatment in diverse hospitals. However, critical access hospitals (CAHs) have differing resources that could impede stewardship.

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We updated a descriptive analysis of national outpatient antibiotic prescribing during the COVID-19 pandemic. Prescribing volume was lower during 2020 and January-June in 2021 and 2022 compared to corresponding baseline months in 2019. Prescribing approached or exceeded baseline during July-December of 2021 and 2022 for all antibiotics, especially for azithromycin.

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Article Synopsis
  • The study examines the effectiveness of antibiotics in treating pediatric pneumonia in children and adolescents, specifically comparing outcomes for those who received antibiotics versus those who did not.
  • Data was collected from a multistate claims database for Medicaid-insured individuals under 17 years old who were diagnosed with pneumonia between 2017 and 2019, taking into account factors to minimize bias.
  • Results showed that treatment failure rates were slightly higher in children who did not receive antibiotics (10.7%) compared to those who did (8.7%), although the difference was not clinically significant.
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  • The study focused on posterior vertebral column subtraction osteotomy (PVCSO), a surgical procedure aimed at alleviating symptoms in patients with recurrent tethered cord syndrome (TCS) by shortening the spinal column and relieving tension on the spinal cord.
  • Researchers retrospectively analyzed six patients who underwent PVCSO from 2019 to 2023, measuring changes in spinal cord dimensions through MRI and recording clinical outcomes such as motor function and pain relief after surgery.
  • Results showed significant improvements in motor function for all patients, sensory function for 40%, and pain relief for 83%, along with notable anatomical changes in the spinal cord, indicating successful outcomes and minimal complications associated with the surgery.
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  • Some experts and patients worked together to create a set of important data to help study childhood lupus, a disease that affects children.
  • They made two datasets: a Core Dataset with 46 necessary items and an Expanded Dataset with 26 extra items, to help gather more information.
  • This new information will help researchers around the world study childhood lupus better by using the same important facts and details.
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Importance: In the US, 50% of all pediatric outpatient antibiotics prescribed are unnecessary or inappropriate. Less is known about the appropriateness of pediatric outpatient antibiotic prescribing.

Objective: To identify the overall percentage of outpatient antibiotic prescriptions that are optimal according to guideline recommendations for first-line antibiotic choice and duration.

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Article Synopsis
  • * Among 540 children studied, Black children were found to have significantly lower chances of reaching LLDAS and higher disease activity compared to their White counterparts, with 41% of Black children living in the most disadvantaged neighborhoods.
  • * The findings suggest that addressing underlying issues related to race and neighborhood socioeconomic status is critical for improving treatment outcomes and reducing health disparities in cSLE.
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  • Immunodeficiency disorders, particularly primary immunodeficiency disorders (PIDDs), can significantly impact patients' health and quality of life, affecting approximately 1-2% of the population, with males being more frequently diagnosed than females.
  • * PIDDs, if left untreated, can lead to high mortality rates due to infections, respiratory issues, and cancers, as well as a greater disease burden compared to conditions like diabetes and COPD.
  • * Effective management of PIDDs requires a multidisciplinary approach, focusing on medical care, mental health support, and quality of life improvements to enhance patient outcomes.
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Background: Better understanding differences associated with antibiotic prescribing for acute sinusitis can help inform antibiotic stewardship strategies. We characterized antibiotic prescribing patterns for acute sinusitis among commercially insured adults and explored differences by patient- and prescriber-level factors.

Methods: Outpatient encounters among adults aged 18 to 64 years diagnosed with sinusitis between 2016 and 2020 were identified by national administrative claims data.

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Objective: Intramedullary spinal cord lipomas without spinal dysraphism are rare. Although they are benign tumors, they can cause significant neurological deficits. Their tight adherence to the spinal cord presents a challenge for resection.

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Background: The safety and efficacy of mycophenolate mofetil (MMF) for lupus nephritis (LN) treatment is established in adults and in some children. MMF is rapidly converted to the biologically active metabolite mycophenolic acid (MPA) whose pharmacokinetics (PK) is characterized by large inter- and intra-individual variability.

Methods/design: This randomized, double-blind, active comparator, controlled clinical trial of pediatric subjects with proliferative LN compares pharmacokinetically-guided precision-dosing of MMF (MMF, i.

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