[Acute renal failure after gadolinium-containing contrast medium in preexisting chronic renal failure stage II].

Background: Gadolinium-containing contrast media in low concentration as normally used in magnetic resonance imaging are considered to be safe in patients with slightly impaired renal function.

Case Report: A case of acute renal failure after administration of gadolinium 0.09 mmol/kg body weight in a patient with preexisting mild renal failure (creatinine clearance 55 ml/min) is described.

[Does routine angiographic control make sense after percutaneous coronary intervention?].

Background And Purpose: Is it possible to avoid routine coronary angiography after previous coronary intervention, if angiography is done only on patients with pathologic or questionable results in noninvasive diagnostic tests (recent medical history, exercise electrocardiography)?

Patients And Methods: During the period from January 1996 until December 2000, all patients who underwent interventional treatment of coronary vessels (n = 509) were routinely reexamined by coronary angiography within 3-6 months. Out of the total group as well as out of the patients with normal exercise electrocardiography, all patients with significant restenosis or new stenosis were identified. Patients with pathologic exercise electrocardiography and patients who could not tolerate exercise electrocardiography were marked.

[Lysis of an extensive thrombus in the internal carotid artery using a glycoprotein IIb/IIIa receptor antagonist].

History: A 55-year-old man was admitted with acute right-sided arm and leg paralysis and motor aphasia, which were regressing at time of admission. He was known to have had several episodes of abnormal motor function in the right arm resulting from transitory cerebral ischaemic attacks. He was a heavy smoker.

[Yersinia arthritis. Long-term follow up].

Twenty-two patients were followed for a mean of 10.7 years after acute Yersinia arthritis. Their clinical course, agglutinating antibodies, and laboratory parameters of inflammation were analyzed.

Long term prognosis in yersinia arthritis: clinical and serological findings.

Twenty two patients were followed up for a mean of 10.7 years after acute yersinia arthritis. Their clinical course, agglutination antibodies, antibodies against plasmid coded yersinia proteins, and laboratory parameters of inflammation were analysed.

[Atrial lipoma as a cause of tachycardiac arrhythmia].

A 41-year-old man had paroxysmal tachycardic arrhythmias. Computed tomography revealed a right atrial lipoma, 7 cm in diameter. After the tumour had been removed (with histological confirmation of the diagnosis) the arrhythmia ceased.

[Intracellular gold content of circulating blood cells using various gold compounds].

Evidence on the action mechanisms of gold salts in the treatment of rheumatoid arthritis is still inconclusive. The intracellular localization of the place of action is likely. Therefore not only the serum gold levels but also the intracellular concentration of gold are of special interest.

[Successful conservative treatment of bronchial carcinoid with Cushing's syndrome due to ectopic ACTH production].

In a 53-year-old female patient with typical clinical Cushing's syndrome increased blood sugar levels, hypokalaemia, increased non-dexamethasone suppressable plasma cortisol levels and increased ACTH values in serum were observed. CAT scanning revealed bilateral adrenocortical hyperplasia. The endocrine anterior pituitary function was normal.

[Hyperostosis of the sterno-clavicular joint - an enthesopathy?].

Erosion of the insertions of tendons and ligaments in bone (i.e. of the enthesis) due to chronic aseptic inflammation causes reparative ossification.

[Protein binding of gold in serum of patients treated with different gold preparations].

Binding of gold to serum proteins of patients treated with Na-aurothiomalate (AM), gold keratinate (GK) and triethylphosphine gold (PG) was compared. In addition the pattern of distribution of gold in serum of healthy donors after in vitro incubation with these compounds and with tetrachlorogoldacid (GC) was studied. Serum specimens were fractionated by gel filtration (Sephadex G 200), gold was measured by atomic absorption spectroscopy, concentration of protein was calculated by extinction at 280 nm.

Distribution of gold in serum erythrocytes and white blood cells after in vitro incubation and during chrysotherapy with different gold compounds.

We examined the binding of gold to serum proteins and the gold level in serum and in blood cells both after incubation in vitro and under longterm treatment with 3 gold compounds. Gold was measured by atomic absorption spectrophotometry, a serum fractionated by gel chromatography; blood cells were separated by gradient centrifugation, and intracellular gold was measured after pressure decomposition and MIBK-extraction. Aurothiomalate (GSTM), gold keratinate (GK), and auranofin (AF) were used.

Oral gold therapy with auranofin (SK&F 39162). A multicenter open study in patients with rheumatoid arthritis.

One hundred and fifty patients with rheumatoid arthritis received 6 mg of auranofin daily for 2-24 months. Thirty patients were withdrawn from the study, and 82 patients were observed for 12 months. Statistical evaluation was available for 74 patients at weeks 24, 38, and 48, respectively.

[Clinical trial in couples of effectiveness and side-effects of gold and D-penicillamine in long term treatment of rheumatoid arthritis (author's transl)].

A prospective clinical trial in couples was done to compare effectiveness and toxicity of gold and D-penicillamine (D-Pen.) in treatment of rheumatoid arthritis (r.A.

[Pharmacokinetics of gold after administration of aurokeratinate (author's transl)].

Aurokeratinate (Auro-Detoxin) was administered intramuscularly to patients with chronic rheumatoid arthritis, using two different dosage schedules and measuring serum gold concentration. (1) Using slowly rising doses (as generally practised) the gold level gradually rose to 3.2 microgram/ml after four weeks (before the ninth injection), without reaching cumulation equilibrium.

[Yersinia arthritis (author's transl)].

Clinical picture and differential diagnosis of Yersinia arthritis are shown by means of three own observations. It is an acute oligoarthritis affecting especially knee- and ankle-joints. The involved joints are very painful, swollen and warm.

B cell activity in rat bone marrow and spleen during primary and secondary response: dependence on strength of antigen.

B cell activity was studied in the spleen and the bone marrow of inbred rats after applying xenogeneic erythrocytes of different antigenic strength (mouse or sheep). The hemolytic plaque technique of Cunningham was used. In contrast to the studies of other authors with other species, these experiments showed that in the rat the kinetics of IgM and IgG responses in bone marrow and spleen are principally similar during a primary as well as during a secondary reaction, varying only with the strength of the antigen.

Different suppressive effects of combined cyclophosphamide-antigen treatment compared with exclusive cyclophosphamide treatment on primary and secondary humoral immune reactivity.

The immunosuppressive effect of a combined treatment with antigen (C3H erythrocytes - ME) and cyclophosphamide (CY - dosage 65% LD50) has been studied in inbred CAP rats showing different degrees of immunological reactivity. When primary reactivity existed before treatment, this reactivity was not abolished but diminished. When weak secondary reactivity (after one antigen injection) existed before treatment this reactivity was abolished and again diminished primary reactivity was found.