Molecular characterization of U937-dependent T-cell co-stimulation.

U937 cells provide a co-stimulatory signal for CD3-mediated T-cell activation which is independent of the CD28/CD80/CD86 interaction. This study set out to identify which molecules contribute to this co-stimulatory activity. Monoclonal antibodies (mAb) to the known accessory molecules CD11a, CD18, CD54 and CD45, all inhibited T-cell proliferation.

Pharmacological adjuncts in the treatment of opioid and cocaine addicts.

Addiction consists of a complex neuropharmacologic behavioral cycle. The positive reinforcement of the drug and the negative reinforcement of withdrawal serve to drive the behavior of obtaining and ingesting the drug. The pharmacological adjuncts that are available today work by interfering with one or another part of the cycle.

A maniclike illness associated with right frontal arteriovenous malformation.

Secondary mania may be caused by metabolic derangements, intoxications, and/or structural lesions, as well as by epilepsy. The authors describe a maniclike illness in a 16-year-old girl in whom a right frontal arteriovenous malformation was discovered. The most effective medical therapy was a combination of lithium and carbamazepine.

Treatment of bulimia with nomifensine.

The authors treated 12 consecutive bulimic patients with nomifensine, a novel antidepressant recently approved for American use. Two patients developed fever, necessitating discontinuation of the drug. Of the other 10 patients, nine showed moderate or better improvement, with strikingly few side effects.

Treatment of bulimia and rapid-cycling bipolar disorder with sodium valproate: a case report.

Sodium valproate, a medication sometimes effective in bipolar disorder, produced a rapid remission of previously refractory bulimia and affective symptoms in a young woman. Like other medications used to treat major affective disorder, valproate may benefit certain patients with bulimia.

Stability of glycolytic enzymes of human erythrocytes.

The stability of various glycolytic enzymes of human erythrocytes has been studied by the mechanical shaking method. The rate of denaturation apparently followed first order kinetics. The t1/2, the shaking time required to denature 50% of the original activity, for glucose-6-phosphate dehydrogenase, phosphofructokinase, and pyruvate kinase was less than 1 min; that for hexokinase, 6-phosphogluconate dehydrogenase, and monophosphoglyceromutase was between 2 and 13 min; that for all the other enzymes was more than 30 min.