Assessment of anthropogenic particles in Holothuria sanctori from Tenerife (Canary Islands, Spain).

Sea cucumbers play a key role in maintaining the health of coastal marine ecosystems. The aim of this research was to evaluate the presence of anthropogenic particles in sea cucumbers of the species Holothuria sanctori in intertidal pools from Tenerife (Canary Islands, Spain) and in the surrounding seawater. In the case of sea cucumbers (n = 18), the gastrointestinal tract (particles ingested directly from the sediment) and Cuvierian tubules (particles presence as a result of gas exchange with seawater) were analysed separately.

Anthropogenic debris pollution in yellow-legged gull (Larus michahellis atlantis) nests in biosphere reserves of the Canary Islands.

Anthropogenic debris, particularly plastic pollution, has emerged as a significant environmental threat to biodiversity. Given that seabirds interact with artificial debris through ingestion, entanglement, and nest incorporation, it is particularly important to quantify the quantity, origins, and chemical composition of these debris items. In this work, it was evaluated for the first time the occurrence of anthropogenic debris in nests of yellow-legged gull (Larus michahellis atlantis) in biosphere reserves of the Canary Islands (Spain).

Anthropogenic particles determination in northern krill (Meganyctiphanes norvegica) from the Azores region: A keystone species for marine food webs.

Plastic pollution poses a significant threat to marine ecosystems. Microfibres from fabrics have become the most prevalent shape of microplastic found in the marine environment. The northern krill (Meganyctiphanes norvegica) is the most abundant euphausiid species in the northern hemisphere, playing a crucial role in various pelagic ecosystems.

Beneath the water column: Uncovering microplastic pollution in the sublittoral coastal sediments of the Canary Islands, Spain.

Marine ecosystems pollution by microplastics (MPs) is a global problem of special concern. The present study examines the prevalence and distribution of MPs and cellulosic particles in sublittoral coastal sediments of the Canary Islands archipelago (Spain). At twenty-six different locations alongside seven islands, three samples were taken parallel to the shoreline between 1 and 10 m depth (n = 78).

A nationwide monitoring of atmospheric microplastic deposition.

Plastic production continues to increase every year, yet it is widely acknowledged that a significant portion of this material ends up in ecosystems as microplastics (MPs). Among all the environmental compartments affected by MPs, the atmosphere remains the least well-known. Here, we conducted a one-year simultaneous monitoring of atmospheric MPs deposition in ten urban areas, each with different population sizes, economic activities, and climates.

Ag S Biocompatible Ensembles as Dual OCT Contrast Agents and NIR Ocular Imaging Probes.

Ag S nanoparticles (NPs) emerge as a unique system that simultaneously features in vivo near-infrared (NIR) imaging, remote heating, and low toxicity thermal sensing. In this work, their capabilities are extended into the fields of optical coherence tomography (OCT), as contrast agents, and NIR probes in both ex vivo and in vivo experiments in eyeballs. The new dual property for ocular imaging is obtained by the preparation of Ag S NPs ensembles with a biocompatible amphiphilic block copolymer.

Three-dimensional evaluation of beaches of oceanic islands as reservoirs of plastic particles in the open ocean.

The quantification of plastic debris on beaches has been extensively used as an indicator of plastic pollution in the marine environment. However, most efforts have focused on surface layers, with few investigations looking deeper into the substrate, thus underestimating total standing stocks. Such information is crucial to improve our understanding of where plastic accumulates in the oceans.

TLR2 Is Highly Overexpressed in Retinal Myeloid Cells in the rd10 Mouse Model of Retinitis Pigmentosa.

Retinitis pigmentosa (RP) is a genetically heterogeneous disease and the predominant cause of hereditary blindness. Irrespective of the causative mutation, traits common to all forms of RP include photoreceptor dysfunction and death, activation of the retinal glial component, and retinal inflammation. Activation of Toll-like receptors (TLRs) in response to tissue damage is associated with inflammatory processes that contribute to neurodegeneration.

Bacterial Colonization of Microplastics at the Beaches of an Oceanic Island, Tenerife, Canary Islands.

(1) Isolated systems, such as oceanic islands, are increasingly experiencing important problems related to microplastic debris on their beaches. The formation of microbial biofilm on the surface of microplastics present in marine environments provides potential facilities for microorganisms to survive under the biofilm. Moreover, microplastics act as a vehicle for the dispersion of pathogenic organisms, constituting a new route of exposure for humans.

Fluoride Levels in Supply Water from the Canary Islands Region.

The Canary Islands, located in the Atlantic Ocean, are an archipelago of volcanic origin which, for decades, has been affected by natural fluoride contamination in the water supply of some of its islands, mainly the island of Tenerife. In addition, recent volcanic eruptions in the archipelago and the increased demand for water supply have led to an increase in the fluoride content in other areas which, historically, were not affected. Fluoride content was determined in 274 water supply samples from the most populated islands of the Canary Islands (Tenerife and Gran Canaria) collected during the months of June 2021 to May 2022.

Microplastics in snow of a high mountain national park: El Teide, Tenerife (Canary Islands, Spain).

Human activities have introduced high amounts of microplastics (MPs) into the atmosphere that can be transported long distances and be later deposited in terrestrial and aquatic ecosystems with precipitation (rain or snow). In this work, it has been assessed the presence of MPs in the snow of El Teide National Park (Tenerife, Canary Islands, Spain, 2150-3200 m above sea level) after two storm episodes (January-February 2021). The data set (63 samples) was divided into three groups: i) samples from "accessible areas" (after the first storm episode and in places with a strong previous/recent anthropogenic activity); ii) "pristine areas" (after the second storm episode, in places with no previous anthropogenic activity), and iii) "climbing areas" (after the second storm episode, in places with a soft recent anthropogenic activity).

The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers Arrestin-1 Translocation upon Light Reception in the Retina.

The short and long isoforms of FAIM (FAIM-S and FAIM-L) hold important functions in the central nervous system, and their expression levels are specifically enriched in the retina. We previously described that knockout (KO) mice present structural and molecular alterations in the retina compatible with a neurodegenerative phenotype. Here, we aimed to study KO retinal functions and molecular mechanisms leading to its alterations.

Nanoplastics in the soil environment: Analytical methods, occurrence, fate and ecological implications.

Soils play a very important role in ecosystems sustainability, either natural or agricultural ones, serving as an essential support for living organisms of different kinds. However, in the current context of extremely high plastic pollution, soils are highly threatened. Plastics can change the chemical and physical properties of the soils and may also affect the biota.

Plastitar: A new threat for coastal environments.

Oil residues have been frequently found on the coasts all over the world as a result of different accidental releases. Their partial evaporation and solidification onto the coastal rocks can produce the formation of a new solid structure forming an agglomerate with other materials, mainly microplastics (though wood, glass, sand and rocks were also found), yielding to a new plastic formation, name herein for the first time as "plastitar". These new formations have been found in several of the islands of the Canary Islands archipelago (Spain).

Microplastics Determination in Gastrointestinal Tracts of European Sea Bass () and Gilt-Head Sea Bream () from Tenerife (Canary Islands, Spain).

Microplastic pollution has an extremely widespread distribution, to the extent that microplastics could be ingested by aquatic organisms, including species of commercial importance for fisheries and aquaculture. In this work, the anthropogenic particles content of the gastrointestinal tracts of 86 individuals of cultivated European sea bass (, = 45) and gilt-head sea bream (, = 41) from Tenerife (Canary Islands, Spain) was determined. Samples were bought at local markets and directly transported to the laboratory.

Possible Role of Insulin-Degrading Enzyme in the Physiopathology of Retinitis Pigmentosa.

Insulin-degrading enzyme (IDE) was named after its role as a proteolytic enzyme of insulin. However, recent findings suggest that IDE is a widely expressed, multitask protein, with both proteolytic and non-proteolytic functions. Here, we characterize the expression of IDE in the mammalian retina in both physiological and pathological conditions.

Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa.

Synaptic loss, neuronal death, and circuit remodeling are common features of central nervous system neurodegenerative disorders. Retinitis pigmentosa (RP), the leading cause of inherited blindness, is a group of retinal dystrophies characterized by photoreceptor dysfunction and death. The insulin receptor, a key controller of metabolism, also regulates neuronal survival and synaptic formation, maintenance, and activity.

Recycled wastewater as a potential source of microplastics in irrigated soils from an arid-insular territory (Fuerteventura, Spain).

In this work, the occurrence of microplastics (MPs) in irrigation recycled wastewaters (RWWs) and a desalinated brackish water (DBW) from the arid territory of Fuerteventura (Canary Islands, Spain) was studied. Besides, the presence of MPs in two types of soils (sandy-loam and clay-loamy; with no mulch film or fertilization with sewage sludge applied) irrigated with both water qualities was addressed. Results showed the prevalence presence of cellulosic and polyester microfibers (between 84.

Assessment of microplastic content in Diadema africanum sea urchin from Tenerife (Canary Islands, Spain).

Sea urchins are highly abundant in the marine ecosystem where they graze limiting algal biomass and also serving as food for other predators. In this work, the presence of microplastics in the digestive tracts and gonads of 33 Diadema africanum sea urchins collected at two sampling points in Tenerife (Canary Islands, Spain) was studied. After separation and digestion of the digestive tracts and the gonads, the visualization of the filtrates under the stereomicroscope revealed the presence of 320 items which were microfibers (97.

Microplastic pollution in sublittoral coastal sediments of a North Atlantic island: The case of La Palma (Canary Islands, Spain).

In this work, the microplastic content of sediments collected in July 2020 between 5 and 7 m depth was studied in four locations of La Palma island (Canary Islands, Spain). At each sampling location, three samples were taken parallel to the shoreline. The microplastic content in each sampling corer was studied every 2.

Gene Deletion Delays Retinal Degeneration in Two Genetically Distinct Mouse Models of Retinitis Pigmentosa.

Although considered a rare retinal dystrophy, retinitis pigmentosa (RP) is the primary cause of hereditary blindness. Given its diverse genetic etiology (>3000 mutations in >60 genes), there is an urgent need for novel treatments that target common features of the disease. TLR2 is a key activator of innate immune response.

Arenas Blancas (El Hierro island), a new hotspot of plastic debris in the Canary Islands (Spain).

The present work has studied the incidence and type of micro (1-5 mm), meso (5-25 mm) and macroplastics (>25 mm) that have reached Arenas Blancas beach, located in the north coast of El Hierro island, in the Canary Islands (Spain), from October 2019 to May 2020 (13 sampling dates with 3 sampling points each). Taking into consideration the three studied plastic debris fractions (macro, meso and microplastics), a total of 9206 items were found, which had a total weight of 1169.7 g and a concentration of 891.

Social Environment Ameliorates Behavioral and Immune Impairments in Tyrosine Hydroxylase Haploinsufficient Female Mice.

The social environment can influence the functional capacity of nervous and immune systems, and consequently the state of health, especially in aged individuals. Adult female tyrosine hydroxylase haploinsufficient (TH-HZ) mice exhibit behavioral impairments, premature immunosenescence and oxidative- inflammatory stress. All these deteriorations are associated with a lower lifespan than wild type (WT) counterparts.

GSK-3 Inhibitors: From the Brain to the Retina and Back Again.

Enzyme glycogen synthase kinase-3 (GSK-3) is a candidate pharmacological target for the treatment of neurodegenerative diseases of the brain. Given the many molecular, cellular, and functional features shared by the brain and the retina in both physiological and pathological processes, drugs originally designed to treat neurodegenerative diseases of the brain could be useful candidates for the treatment of retinal degenerative pathologies. Moreover, the accessibility of the eye to noninvasive, quantitative diagnostic techniques allows for easier evaluation of the efficacy of candidate therapies in clinical trials.