Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Intravenous Infusions of PF-07304814 (Lufotrelvir) in Participants Hospitalized With COVID-19.

Background: An urgent need remains for antiviral therapies to treat patients hospitalized with COVID-19. PF-07304814-the prodrug (lufotrelvir) and its active moiety (PF-00835231)-is a potent inhibitor of the SARS-CoV-2 3CL protease.

Method: Eligible participants were 18 to 79 years old and hospitalized with confirmed COVID-19.

Histiocytoid Sweet Syndrome associated with anorectal lymphogranuloma venereum in a patient with HIV infection.

Sweet Syndrome belongs to a group of diseases known as neutrophilic dermatoses. An uncommon variant named Histiocytoid Sweet Syndrome (HSS) can be associated with a variety of conditions, including cancer, infections, drug toxicity and others. Here we present an instance of HSS in an HIV-positive patient in an infectious disease setting.

Recent wildfires in Central Chile: Detecting links between burned areas and population exposure in the wildland urban interface.

Wildfires are gaining importance in the Mediterranean regions owing to climate change and landscape changes due to the increasing closeness between urban areas and forests prone to wildfires. We analysed the dry season wildfire occurrences in the Mediterranean region of Central Chile (32°S-39°30' S) between 2000 and 2017, using satellite images to detect burned areas, their landscape metrics and the land use and covers (vegetal) pre-wildfire, in order to determine the population living in areas that may be affected by wildfires. The existing regulations in western Mediterranean countries (Portugal, Spain, France, and Italy) were used to identify and define the wildland-urban interface (WUI) areas, quantifying the people inhabiting them and estimating the population affected by burned areas from 2001 to 2017.

[Feasibility study of therapeutic exposure in virtual reality for pathological gamblers].

Unlabelled: The experiment presented is the result of a partnership between the Paris-Nanterre University (CLIPSYD laboratory, EA 4430) and the CSAPA Imagine (Simone Veil Hospital, GH Eaubonne-Montmorency). Virtual reality immersion exposure for pathological gamblers is beneficial in the context of cognitive and behavioral interventions. It can be used to evoke the desire to play and to have access to automatic thoughts and mistaken beliefs of the players when they find themselves in a gambling context.

Switching mechanisms in flexible solution-processed TiO₂ memristors.

Memristors are emerging as unique electrical devices with potential applications in memory, reconfigurable logic and biologically inspired computing. Due to the novelty of these devices, the complete details of their switching mechanism is not yet well established. In this work, the switching mechanism of our solution-processed titanium dioxide-based memristor is investigated by studying how variations in the device area and film thickness affect electrical behavior and correlating these behavioral changes to proposed switching mechanisms.

Radiologic aspects of hepatic echinococcosis. Value of the intravenous viscerogram and computed tomography.

Over five years, 105 patients with hepatic echinococcosis were studied. Plain radiographs of the hepatic area yielded the correct diagnosis in 35% of patients. Intravenous viscerograms were diagnostic in all but 14 of the patients (an accuracy of 83%).

Radiological characteristics of primary intestinal lymphoma of the "Mediterranean" type: observations on twelve cases.

Radiological findings in 12 cases of "Mediterranean" lymphoma are analyzed, 4 of which are associated with gammapathy. These findings have not permitted differentiation of this type of lymphoma from those classically described, although there are two signs that strongly suggest this diagnosis: extension of the lesions along wide areas of the small intestine, almost always including the duodenum, and spiculation of the mucosal fold edges, representing massive plasmocyte infiltration of the lamina propria. The principal clinical, immunological, and pathological aspects are described, as well as the radiological differential diagnosis.

Radiological characteristics of perforated pulmonary hydatid cysts.

Perforation of pulmonary hydatid cysts into the bronchial tree was seen in 56 of 239 cases. The resulting radiological signs are much more specific than those seen prior to perforation. These signs are described and correlated with the cystic structures that give rise to them.