Publications by authors named "Hernandez Paniagua Liliana Alejandra"
Bioconjug Chem
September 2024
Article Synopsis
- A new method for forming stable cell aggregates using click chemistry with water-soluble zwitterionic dibenzo cyclooctadiyne (WS-CODY) and azide-modified hyaluronic acid (HA-N) allows for rapid aggregation in just 10 minutes.
- By optimizing the concentrations of HA-N and WS-CODY, researchers ensured effective cross-linking between modified cell surfaces and HA-N, achieving aggregates that remained stable for up to 5 days while maintaining an 80% cell viability rate.
- Transcriptome analysis of the aggregates revealed significant gene expression changes related to cell migration and adhesion, indicating that HA-N-mediated aggregation not only forms the aggregates but also alters cellular behavior, a phenomenon termed 'chemo-resilience,' with
