Liraglutide and the management of overweight and obesity in people with schizophrenia, schizoaffective disorder and first-episode psychosis: protocol for a pilot trial.

Background: People with severe mental illness (SMI) are two to three times more likely to be overweight and obese than the general population and this is associated with significant morbidity and premature mortality. Although lifestyle interventions can support people with SMI to lose weight, some are unable to make the necessary lifestyle changes or, despite making the changes, continue to gain weight.

Objective: To assess the feasibility and acceptability of delivering a full-scale trial evaluating whether liraglutide 3.

Primary prevention of CVD: diet.

Introduction: Diet is important in the cause of many chronic diseases. Individual change in dietary behaviour has the potential to decrease the burden of chronic disease, particularly cardiovascular disease (CVD).

Methods And Outcomes: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of dietary advice in generally healthy adults without existing CVD or increased CVD risk factors to improve cardiovascular outcomes (mortality, cardiovascular events, and cardiovascular risk factors)? We searched: Medline, Embase, The Cochrane Library, and other important databases up to March 2014 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review).

Disseminating results to clinical trial participants: a qualitative review of patient understanding in a post-trial population.

Objective: To identify the most appropriate format for results dissemination to maximise understanding of trial results.

Design: Qualitative.

Setting: Of the original 58 4-T trial centres, 34 agreed to take part in this ancillary research.

Primary prevention of CVD: diet.

Introduction: Diet is important in the cause of many chronic diseases. Individual change in dietary behaviour has the potential to decrease the burden of chronic disease, particularly cardiovascular disease (CVD).

Methods And Outcomes: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of dietary advice in generally healthy adults without existing CVD or increased CVD risk factors to improve cardiovascular outcomes (mortality, cardiovascular events, and cardiovascular risk factors)? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2010 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review).