Effects of D,L-alpha-aminoadipate on postsynaptic amino acid responses in cultured mouse spinal cord neurons.

The effects of the dicarboxylic amino acid, DL-alpha-aminoadipate (DLAA) on amino acid responses have been investigated using intracellular recordings from mouse spinal cord neurons grown in dissociated cell culture. DL-alpha-Aminoadipate markedly antagonized postsynaptic responses to iontophoretically appllied aspartate; antagonism of glutamate was much less prominent. DL-alpha-Aminoadipate altered the affinity of aspartate for its receptor while having no observed effects on aspartate-receptor cooperativity.