Influence of luminal pore size on the patency rate and endothelialization of polymeric microvenous prostheses.

In microvenous prosthetic surgery a continuous search for better patency rates is necessary to enable a clinical application. In this search for better patencies, modifications in the wall structure are being made. Directions found in the literature suggest that pore size plays an important role in achieving better patencies.

Activation of the mas oncogene involves coupling to human alphoid sequences.

We have shown previously that mouse NIH3T3 cells transfected with DNA from a human ovarian carcinoma were rendered tumourigenic by an activated mas oncogene in four independent transfection experiments. In all cases the 5'-noncoding region was rearranged in comparison to the original ovarian tumour DNA. We now report that in all four transfectants the newly acquired sequences consist of human centromeric alpha satellite repeat DNA.

Identification of variable simple sequence motifs in 19q13.2-qter: markers for the myotonic dystrophy locus.

Variable simple sequence motifs (VSSMs), or microsatellites, were used for the genetic delimitation of the myotonic dystrophy (DM) region at 19q. Three simple sequence motifs were identified in and around the ERCC1 DNA-repair gene at 19q13.2-13.

ras oncogene activation in human ovarian carcinoma.

Samples of 37 fresh human ovarian tumor biopsies were screened to detect proto-oncogene amplification and ras mutations. Three samples showed c-K-ras2 amplification; none of the other oncogenes tested revealed any gene amplification. 5-, 25-, and 120-fold amplifications were assessed by dilution experiments and soft laser densitometry.

High frequency of mas oncogene activation detected in the NIH3T3 tumorigenicity assay.

In four independent transfection experiments performed with high molecular weight DNA isolated from a human ovarian carcinoma, oncogenic NIH3T3 cells contained an activated mas gene in the in vivo tumorigenicity assay. Varying from 1.8 to 3.