Biocompatibility and mechanical properties evaluation of chitosan films containing an N-acylhydrazonic derivative.

The N-acylhydrazone subunit is considered a privileged structure in medicinal chemistry for its importance in pharmaceutical research. Also, alternative methods to deliver these molecules have a great pharmaceutical interest. Therefore, the objective of this work was to encapsulate JR19, an N-acyl hydrazone subunit, into chitosan films and evaluate several properties relevant for transdermal delivery, including biocompatibility using in vitro tests.

Acute superoxide scavenging restores depressed baroreflex sensitivity in renovascular hypertensive rats.

In some pathological conditions such as hypertension, there is an impairment in the autonomic control of blood pressure resulting in changes in baroreflex sensitivity. In the present study we tested the hypothesis that acute superoxide scavenging would restore the reduced baroreflex sensitivity in renovascular hypertension. Male Wistar rats underwent 2-Kidney-1-Clip (2K1C) or sham surgery and were maintained untouched for six weeks to develop hypertension.