Precision Measurement of Vibrational Quanta in Tritium Hydride.

Saturated absorption measurements of transitions in the (2-0) band of radioactive tritium hydride are performed with the ultrasensitive noise-immune cavity-enhanced optical-heterodyne molecular spectroscopy intracavity absorption technique in the range 1460-1510 nm. The hyperfine structure of rovibrational transitions of tritium hydride, in contrast to that of hydrogen deuteride, exhibits a single isolated hyperfine component, allowing for the accurate determination of hyperfineless rovibrational transition frequencies, resulting in R(0)=203 396 426 692(22)  kHz and R(1)=205 380 033 644(21)  kHz. This corresponds to an accuracy 3 orders of magnitude better than previous measurements in tritiated hydrogen molecules.

Mental health status according to the dual-factor model in Swedish adolescents: A cross sectional study highlighting associations with stress, resilience, social status and gender.

In this cross-sectional study, we aimed to I) investigate the dual-factor model of mental health by forming and describing four participant groups and II) examine associations between mental health status and background factors, school-related factors, stress, and resilience among adolescents in a community population in Sweden. Data were collected through a survey completed by 2,208 students in lower and upper secondary school on the Swedish island of Gotland. After missing data were removed, a total of 1,833 participants were included in the study.

'Feeling down one evening doesn't count as having mental health problems'-Swedish adolescents' conceptual views of mental health.

Aims: To explore Swedish adolescents' conceptual views of mental health and mental health problems.

Design: A qualitative descriptive study design.

Methods: Semi-structured focus group interviews and individual interviews were conducted with, in total, 32 Swedish adolescents (15-18 years old) in October-November 2020.

Precision measurement of the fundamental vibrational frequencies of tritium-bearing hydrogen molecules: T, DT, HT.

High-resolution coherent Raman spectroscopic measurements of all three tritium-containing molecular hydrogen isotopologues T2, DT and HT were performed to determine the ground electronic state fundamental Q-branch (v = 0 → 1, ΔJ = 0) transition frequencies at accuracies of 0.0005 cm-1. An over hundred-fold improvement in accuracy over previous experiments allows the comparison with the latest ab initio calculations in the framework of non-adiabatic perturbation theory including nonrelativisitic, relativisitic and QED contributions.

First use of cenerimod, a selective S1P receptor modulator, for the treatment of SLE: a double-blind, randomised, placebo-controlled, proof-of-concept study.

Objective: To investigate the pharmacodynamics, pharmacokinetics and safety of cenerimod-a potent, oral, selective sphingosine 1-phosphate 1 receptor modulator-in patients with SLE.

Methods: This multicentre, double-blind, placebo-controlled study was conducted in two parts. In part A, patients with SLE were randomised 1:1:1:1 to receive oral cenerimod 0.

The presence of small joint contractures is a risk factor for survival in 439 patients with systemic sclerosis.

Objectives: Analysis of risk factors and mortality of 439 patients with systemic sclerosis (SSc) in a tertiary care centre.

Methods: The mean follow up time was 8.4±5.

[Suffocation due to foreign body aspiration visualized by post-mortem CT].

The aspiration of a foreign body is a high-risk event in the life of an infant or toddler, which needs fast clinical diagnosis and therapy. If the respiratory tract is massively obstructed, the aspiration can be fatal, as shown in the case of an 18-month-old child. The little boy choked on a fragment of a hazelnut shell.

Longer versus shorter daily durations of electrical stimulation during task-specific practice in moderately impaired stroke.

Objective: To examine and compare efficacy of 30-, 60-, and 120-minute repetitive task-specific practice (RTP) sessions incorporating use of an electrical stimulation neuroprosthesis (ESN) on affected upper-extremity (UE) movement.

Design: Prospective, single-blinded, randomized controlled trial.

Setting: Outpatient rehabilitation hospital.

Affected upper-extremity movement ability is retained 3 months after modified constraint-induced therapy.

The practicality and patient compliance of constraint-induced movement therapy limit its application in many clinical environments. For more than a decade, the principal investigator's laboratory has shown efficacy of an outpatient, modified constraint-induced therapy (mCIT). The current study examined whether participants administered mCIT retained motor changes 3 mo after intervention.

Retention of motor changes in chronic stroke survivors who were administered mental practice.

Objective: To determine retention of motor changes 3 months after participation in a regimen consisting of mental practice (MP) combined with repetitive task-specific (RTP) practice.

Design: Prospective, blinded, cohort, pre-post study.

Setting: Outpatient rehabilitation hospital.

Portable neurorobotics for the severely affected arm in chronic stroke: a case study.

Background And Purpose: Few motor therapies increase active movement in the severely impaired arm of individuals with chronic stroke. Existing robotic devices to address this need are large and expensive. This case study describes the application and reports outcomes associated with a repetitive task-specific training (RTP) program incorporating a portable robotic device.

Longer versus shorter mental practice sessions for affected upper extremity movement after stroke: a randomized controlled trial.

Objective: To evaluate and compare efficacy of 20-, 40-, and 60-minute mental practice sessions on affected upper extremity impairment and functional limitation.

Design: Randomized controlled study with multiple baseline design.

Subjects: Twenty-nine subjects with chronic stroke and exhibiting stable, mild hemiparesis.

Computer-based rhythm and timing training in severe, stroke-induced arm hemiparesis.

Objective: We pilot tested the efficacy of computer-based training implementing rhythm and timing in chronic, severe, stroke-induced hemiparesis.

Method: Two chronic stroke patients were administered the upper-extremity section of the Fugl-Meyer Impairment Scale (FM), the Arm Motor Ability Test (AMAT), Stroke Impact Scale (SIS), and Canadian Occupational Performance Measure (COPM). We then administered the computer-based intervention for 60 min, 3 days/wk for 4 wk.

Chronometry of mentally versus physically practiced tasks in people with stroke.

Objective: The purpose of this study was to determine whether chronometry is appropriate for monitoring engagement in mental practice by comparing the time taken for people with chronic stroke to mentally and physically practice five tasks.

Method: Eighteen stroke participants mentally and physically rehearsed each task. Time was recorded for each of the three trials per task.

Combined bracing, electrical stimulation, and functional practice for chronic, upper-extremity spasticity.

Objective: Conventional methods for managing upper-extremity (UE) spasticity are invasive, usually require readministration after a certain time period, and do not necessarily increase UE function. This study examined efficacy of combining two singularly efficacious modalities-UE bracing and electrical stimulation-with functional training to reduce UE spasticity and improve function.

Method: Two chronic stroke patients exhibiting UE spasticity were administered the Modified Ashworth Scale (MAS), the upper-extremity section of the Fugl-Meyer Impairment Scale (FM), the Box and Block Test (B&B), and the Arm Motor Ability Test (AMAT).

Orthotic functional electrical stimulation following botulinum toxin for a young adult with severe hand impairment due to childhood stroke.

ABSTRACT This case report describes the outcomes of a task-specific training protocol using functional electrical stimulation for a young adult with severe hand impairment from a childhood stroke who had a history of tendon transfer and a recent botulinum toxin injection. A 22-year-old female who had a hemorrhagic stroke at age 5, a tendon transfer at 18, and a botulinum toxin injection 6 weeks before study entry, participated in a home- and clinic-based task-specific training program using a functional electrical stimulation orthosis. Training was 30-90 minutes per day, 4 days per week, for 4 weeks.

Telerehabilitation and electrical stimulation: an occupation-based, client-centered stroke intervention.

Objective: We examined the efficacy of a remotely based arm rehabilitation regimen. A 62-year-old man participated in occupation-based, task-specific practice of activities of daily living (ADLs) >3 years after stroke. The entire regimen was administered over the Internet using personal computer-based cameras and free network meeting software.

[Posterior tibial nerve stimulation in the management of overactive bladder: a prospective and controlled study].

Unlabelled: The aim of this study was to evaluate the efficacy of the Posterior Tibial Nerve stimulation in women with overactivity bladder symptoms and the impact in the quality of life using the Overactivity Bladder Questionnaire (OABq).

Methods: thirty seven women from female urology outpatient clinic of the Hospital das Clinicas de Campinas (HC/UNICAMP) were enrolled in this prospective, controlled and randomized clinical trial. The patients were randomly placed in one of two groups: TREATMENT GROUP: patients were submitted to tibial posterior nerve electrical stimulation (n=21) and Sham group: patients had electrodes placed without electricity (n = 16).

Activity-based electrical stimulation training in a stroke patient with minimal movement in the paretic upper extremity.

Background: Existing task-specific practice interventions do not increase movement in stroke patients exhibiting minimal distal movement in the paretic upper extremity. Although often used, an important limitation of conventional electrical stimulation is that it does not involve task-specific practice.

Objective: To determine the impact of an activity-specific electrical stimulation program on paretic limb impairment, functional limitation, and ability to perform valued activities in a subacute stroke patient exhibiting minimal paretic wrist and hand movement.

Arcus to arcus microsling: technique and preliminary results.

Sling procedures have been around for decades in the management of female stress urinary incontinence (SUI), but only in the past decade have they become the preferred technique. The arcus to arcus microsling is an anatomical approach that involves placing a midurethral low-tension tape anchored to the obturator internus muscles bilaterally at the level of the tendinous arc. From February 2005 to July 2006, 20 female patients (mean age=53 years old) with SUI underwent arcus to arcus microsling procedure.

Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression.

Background: In vivo studies on HIV-1 pathogenesis and testing of antiviral strategies have been hampered by the lack of an immunocompetent small animal model that is highly susceptible to HIV-1 infection. Since native rodents are non-permissive, we developed transgenic rats that selectively express the HIV-1 receptor complex, hCD4 and hCCR5, on relevant target cells. These animals display a transient low-level plasma viremia after HIV-1YU-2 infection, demonstrating HIV-1 susceptibility in vivo.

[Correlation between urogenital prolapse and detrusor overactivity].

Purpose: To evaluate the urodynamic characteristics of a series of women with stress urinary incontinence presenting various rates of vaginal prolapse.

Methods: 92 female patients were included in this study, mean age was 48 years (range 29-75). All patients underwent urogynecologic physical examination (vaginal prolapse was graded) and complete urodynamic study in order to detect the presence of detrusor overactivity.

Urea promotes polyproline II helix formation: implications for protein denatured states.

It is commonly assumed that urea denatures proteins by promoting backbone disorder, resulting in random-coil behavior. Indeed, it has been demonstrated that highly denatured proteins obey random-coil statistics. However, the random-coil model is specified by the global geometric properties of a polymeric chain and does not preclude locally ordered backbone structure.

Biophysical characterization of ERp29. Evidence for a key structural role of cysteine 125.

ERp29 is a major resident of the endoplasmic reticulum (ER) that seemingly plays an important role in most animal cells. Although a protein-folding association is widely supported, ERp29's specific molecular function remains unknown. A chaperone activity was postulated from evidence that ERp29 forms multimers like the classical ER chaperones, but conflicting results have emerged from our recent studies.

Vagus-mediated activation of mucosal mast cells in the stomach: effect of ketotifen on gastric mucosal lesion formation and acid secretion induced by a high dose of intracisternal TRH analogue.

TRH analogue, RX 77368, injected intracisternally (i.c.) at high dose (3 microg/rat) produces gastric mucosal lesion formation through vagal-dependent pathway.