Publications by authors named "Hermann Klasen"
Article Synopsis
- * Among 526 eligible patients, those aged 70 or older showed a lower response rate to chemotherapy (44% compared to 57% for younger patients) and experienced higher rates of severe side effects like leukopenia and increased mortality during therapy.
- * Findings indicate that elderly patients have significantly worse progression-free survival and overall survival compared to younger patients, which is attributed to lower treatment intensity and response rates in this age group.
Background: The DNA damage by platinum cytostatics is thought to be the main cause of their cytotoxicity. Therefore the measurement of the DNA damage induced by cis- and carboplatin should reflect the sensitivity of cancer cells toward the platinum chemotherapeutics.
Methods: DNA damage induced by cis- and carboplatin in primary cells of ovarian carcinomas was determined by the alkaline comet assay.
Purpose: To search for subclinical systemic disease in bone marrow and peripheral blood in patients with primary CNS lymphoma (PCNSL) to elucidate whether extracerebral relapse may represent a sequel of initial occult systemic disease rather than true extracerebral spread.
Patients And Methods: Bone marrow and peripheral-blood specimens of 24 PCNSL patients were examined using polymerase chain reaction (PCR) for analysis of clonally rearranged immunoglobulin heavy-chain (IgH) genes.
Results: Identical dominant PCR products were found in bone marrow aspirates, blood samples, and tumor biopsy specimens of two patients, indicating that the same tumor cell population is present in the CNS and in extracerebral sites.