[Viral Hepatitis A over imposed on chronic hepatic damage due to tamoxifen: report of a case].

A case of Hepatitis A is reported in a patient prescribed tamoxifen after surgery for breast cancer and taking tamoxifen 20 mg/day for two and a half years. Documented is the indirect development of Hepatitis A and tamoxifen-induced hepatic damage.

[Vaccination against Hepatitis B: 20 years later].

More than 20 years have elapsed since 1984, when vaccination against Hepatitis B began, first with a plasma-derived vaccine and later a recombinant DNA-derived vaccine, and during this period important changes have taken place in several aspects of this disease: the acute and chronic infection rates, the mortality of fulminant Hepatitis B in infants and the incidence of hepatocellular carcinoma have been effectively reduced by approximately 25%. Vaccination during childhood has produced adequate protection for up to 20 years later. The appearance of Hepatitis B surface gene mutants in DNA HBV positive children has been confirmed, gradually increasing from 7.

[Prevalence of Hepatitis B infection and risk factors in two groups of pregnant adolescents related to the number of sexual partners].

Background Information: Hepatitis B has different routes of transmission and it is maintained in human populations mainly via transmission from person to person during intense physical contact, such as perinatal contact, contact during hetero and homosexual intercourse and non-sexual physical contact between children, their mothers and siblings.Migration from the provinces to the big cities of the country, added to changes in social behavior, specially among young people, have led to an increase in unprotected sexual encounters, with the resulting greater risk of contracting hepatitis B.

Patients And Methods: We included 1048 adolescent women between the ages of 14 and 19, pregnant and apparently healthy, who came to the Perinatal Maternal Institute (IMP) between August 2003 and February 2004.