Residual microglia following short-term PLX5622 treatment in 5xFAD mice exhibit diminished NLRP3 inflammasome and mTOR signaling, and enhanced autophagy.

While moderately activated microglia in Alzheimer's disease (AD) are pivotal in clearing amyloid beta (Aβ), hyperactivated microglia perpetuate neuroinflammation. Prior investigations reported that the elimination of ~80% of microglia through inhibition of the colony-stimulating factor 1 receptor (CSF1R) during the advanced stage of neuroinflammation in 5xFamilial AD (5xFAD) mice mitigates synapse loss and neurodegeneration. Furthermore, prolonged CSF1R inhibition diminished the development of parenchymal plaques.

Residual Microglia Following Short-term PLX5622 Treatment in 5xFAD Mice Exhibit Diminished NLRP3 Inflammasome and mTOR Signaling, and Enhanced Autophagy.

Chronic neuroinflammation represents a prominent hallmark of Alzheimer's disease (AD). While moderately activated microglia are pivotal in clearing amyloid beta (Aβ), hyperactivated microglia perpetuate neuroinflammation. Prior investigations have indicated that the elimination of ∼80% of microglia through a month-long inhibition of the colony-stimulating factor 1 receptor (CSF1R) during the advanced stage of neuroinflammation in 5xFamilial AD (5xFAD) mice mitigates synapse loss and neurodegeneration without impacting Aβ levels.

Effort-reward imbalance and its association with sociocultural diversity factors at work: findings from a cross-sectional survey among physicians and nurses in Germany.

Objective: Due to staff shortages and reports of high work stress, work conditions of hospital physicians and nurses receive wide attention. Additionally, sociocultural diversity of the workforce and patient population is increasing. Our study aim is to analyze how individual and organizational diversity-related factors are associated with the experience of staff's work stress.

Retrospective evaluation of carboxyhemoglobin and methemoglobin levels in dogs and cats with respiratory disease.

Objective: To evaluate carboxyhemoglobin (COHb) and methemoglobin (MetHb) levels in dogs and cats with respiratory disease in the ICU.

Design: Retrospective study.

Setting: University veterinary teaching hospital.

Participation in genetic research among Latinx populations by Latin America birth-residency concordance: a global study.

Latinx populations are underrepresented in DNA-based research, and risk not benefiting from research if underrepresentation continues. Latinx populations are heterogenous; reflect complex social, migration, and colonial histories; and form strong global diasporas. We conducted a global study using a survey tool (Amazon's Mechanical Turk portal) to ascertain willingness to participate in genetic research by Latin America birth-residency concordance.

Informal caregivers during the COVID-19 pandemic perceive additional burden: findings from an ad-hoc survey in Germany.

Background: While the relation between care involvement of informal caregivers and caregiver burden is well-known, the additional psychosocial burden related to care involvement during the COVID-19 pandemic has not yet been investigated.

Methods: A total of 1000 informal caregivers, recruited offline, participated in a cross-sectional online survey from April 21 to May 2, 2020. Questionnaires were used to assess COVID-19-specific changes in the care situation, negative feelings in the care situation, problems with implementation of COVID-19 measures, concerns/excessive demands, loss of support, change in informal caregivers' own involvement in care and problems with provision, comprehension & practicability of COVID-19 information, and to relate these issues to five indicators of care involvement (i.

Dimers and trimers of diphosphenes: a wealth of cyclo-phosphanes.

Various new P-based ring systems were synthesised by transferring established reaction routes from NP chemistry to the analogous PP compounds. Due to the different electronic situations of phosphorus and nitrogen with respect to s and p character of the lone pair, different reactivity of the phosphorus compounds was observed, especially with regard to the specificity of the reactions and the stability of the products. Whereas Mes*NPCl (Mes*=2,4,6-tri-tert-butylphenyl) is stable in the solid state and in solution, the formal phosphorus congener Mes*PPCl is highly reactive and could not be observed.

Neuropsychological functioning in adolescents and young adults with major depressive disorder--a review.

While neuropsychological dysfunction is a contributor to major depressive disorder (MDD) in adult MDD, little is known about neuropsychological function in MDD during adolescence and early adulthood. The aim of this review is to evaluate literature on neuropsychological function in this young age group. A database search of Medline, the Cochrane database and PsycInfo was conducted.

Azidophosphenium cations: versatile reagents in inorganic synthesis.

This work describes the synthesis and characterization of a series of iminophosphorane-substituted phosphenium cations of the type [R2NPNP(Cl)2NPNR'2][GaCl4] [R = iPr; R' = iPr (7[GaCl4]), SiMe3 (8)], which are directly derived from azidophosphenium salt [iPrNPN3][GaCl4] (2iPr[GaCl4]) and the corresponding chlorophosphane R2NPCl2. The reactivity of 7[GaCl4] toward 2,3-dimethylbutadiene (dmb) and 2,2'-bipyridine (bipy) was investigated, resulting in the formation of 7-dmb[GaCl4] and 7-Cl. In addition, self-condensation of [(Me3Si)2NPN3][GaCl4] (2SiMe3[GaCl4]) was studied in detail, and [(Me3Si)2NPNP(XY)N(SiMe3)2][GaCl4] [X = Cl; Y = Cl (13), N3 (14)] were determined as products on the basis of (31)P NMR spectroscopy.

Structure and bonding of novel acyclic bisaminoarsenium cations.

The synthesis and characterization of a salt bearing a labile bisaminoarsenium cation of the type {[(Me3Si)2N]2As}(+) (9a) are described, which was obtained in the reaction of the chloroarsane [(Me3Si)2N]2AsCl (8) with GaCl3. Reacting 8 with AgOTf did not yield an arsenium salt, but the cyclo-diarsadiazane [(Me3Si)2NAs-μ-NSiMe3]2 (11) was obtained in excellent yields. Moreover, the reactivity of the analogous antimony species [(Me3Si)2N]2SbCl (12) was studied.

On the synthesis and reactivity of highly labile pseudohalogen phosphenium ions.

The synthesis and characterization of salts bearing highly labile pseudohalogen-substituted aminophosphenium cations of the type [(Me3Si)2NPX][GaCl4] (X = NCO, NCS, O(SiMe3)) and their respective reactivity toward Lewis bases (4-dimethylaminopyridine, dmap) and dienes (2,3-dimethyl-1,3-butadiene, dmb; 1,3-cyclo-hexadiene, chd) are described. As π-acidic species, aminophosphenium cations react with dmap at low temperatures to yield adduct salts of the type [(Me3Si)2NP(dmap)X][GaCl4] (X = Cl, N3, NCO) which were fully characterized. In the reaction with dienes at -50 °C, salts bearing phospholenium cations were obtained that could be structurally characterized.

Chlorine/methyl exchange reactions in silylated aminostibanes: a new route to stibinostibonium cations.

The Lewis acid assisted triflate/methyl, azide/methyl, and chlorine/methyl exchange reactions between silicon and antimony have been studied in the reaction of R(Me(3)Si)N-SbCl(2) (R = Ter) with AgOTf, AgN(3), KOtBu, GaCl(3), and Me(3)SiN(3)/GaCl(3), resulting in the formation of different methylantimony compounds. Furthermore, R(Me(3)Si)N-SbCl(2) (R = SiMe(3)) was reacted with GaCl(3) at low temperatures to yield a hitherto unreported amino(chloro)stibenium cation, the proposed intermediate in methyl exchange reactions. Tetrachloridogallate salts bearing different stibinostibonium cations such as [(Me(3)Sb)SbMe(2)](+) and [(Me(3)Sb)(2)SbMe](2+) along with the GaCl(3) adduct of SbMe(3) were isolated from such R(Me(3)Si)N-SbCl(2)/GaCl(3) mixtures (R = SiMe(3)) at ambient temperatures, depending on the reaction parameters.

A structured reading algorithm improves telemetric detection of atrial fibrillation after acute ischemic stroke.

Background And Purpose: Anticoagulation is a highly effective secondary prevention in patients with cardioembolic stroke and atrial fibrillation/flutter (AF). However, the condition remains underdiagnosed, because paroxysmal AF may be missed by diagnostic tests in the acute phase. In this study, the sensitivity of AF detection was assessed for serial electrocardiographic recordings and continuous stroke unit telemetric monitoring with or without a structured algorithm to analyze telemetric data (SEA-AF).

Does the inactivation of leukocytes in blood transfusions during and following liver transplantation by gamma-irradiation have an impact on rejection and infection rate?

Background: Leukocytes transmitted in blood products exert a variety of immunological side-effects. Experience with bone marrow transplant recipients has shown that these can be induced even by very few cells. In liver transplant recipients, who usually receive large amounts of blood products, the effects of transfused leukocytes with regards to the rates of rejection and infection have not yet been investigated.