Publications by authors named "Herieth Ismael Wilson"
Article Synopsis
- The study aimed to examine weight changes in HIV-positive individuals receiving either dolutegravir- or efavirenz-based antiretroviral therapy (ART) in rural Tanzania, where undernutrition is common.
- It analyzed the weight changes over 18 months for 1,205 adults starting ART, finding that those on dolutegravir gained more weight (5.1 kg) compared to those on efavirenz (4.0 kg).
- The results indicated that dolutegravir led to higher obesity rates and increased hypertension risk, particularly in individuals with a higher body mass index before starting treatment.*
Article Synopsis
- The study investigated the prevalence and incidence of renal impairment in people living with HIV (PLWH) in rural Tanzania when switching to ritonavir-boosted protease inhibitors (bPI) as part of their antiretroviral treatment.
- At the time of the switch, 7.6% of the participants exhibited renal impairment, and within this group, 7.4% developed renal issues over an average of 3.5 years.
- Factors contributing to renal impairment included older age, low body mass index, and arterial hypertension, while a longer duration of antiretroviral treatment was linked to a lower risk of developing impairment.
Background: Arterial hypertension is the most prevalent risk factor for cardiovascular disease in sub-Saharan Africa. Only a few and mostly small randomized trials have studied antihypertensive treatments in people of African descent living in sub-Saharan Africa.
Methods: In this open-label, three-arm, parallel randomized controlled trial conducted at two rural hospitals in Lesotho and Tanzania, we compare the efficacy and cost-effectiveness of three antihypertensive treatment strategies among participants aged ≥ 18 years.