Publications by authors named "Herdis M Gudjonsdottir"
We previously mapped susceptibility to stroke to chromosome 5q12. Here we finely mapped this locus and tested it for association with stroke. We found the strongest association in the gene encoding phosphodiesterase 4D (PDE4D), especially for carotid and cardiogenic stroke, the forms of stroke related to atherosclerosis.
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- Stroke is a complex disease with various subtypes and multiple secondary risk factors like hypertension and diabetes, which have their own genetic and environmental influences.
- Researchers conducted a genomewide search for genes that might increase susceptibility to common stroke forms by analyzing data from stroke patients in Iceland and a genealogy database, identifying 476 patients within 179 extended families.
- A significant discovery was made on chromosome 5q12, with a high LOD score indicating strong evidence for a genetic link to stroke; this region, named "STRK1," is novel and not previously associated with known stroke susceptibility loci.