Publications by authors named "Herbert R Marini"
Article Synopsis
- * The research investigated the impact of cadmium chloride (CdCl) on chondrocyte viability and gene expression, finding that higher doses resulted in reduced cell survival and increased markers of cell death.
- * Seleno-methionine (Se-Met) was shown to protect chondrocytes from CdCl damage by improving cell survival and reducing harmful gene expression, suggesting dietary interventions may help mitigate the effects of toxic environmental pollutants.
An acute metabolic complication of diabetes mellitus, especially type 1, is diabetic ketoacidosis (DKA), which is due to an increase in blood ketone concentrations. Sodium/glucose co-transporter-2 inhibitor (SGLT2-i) drugs have been associated with the occurrence of a particular type of DKA defined as euglycemic (euDKA), characterized by glycemic levels below 300 mg/dL. A fair number of euDKA cases in SGLT2-i-treated patients have been described, especially in the last few years when there has been a significant increased use of these drugs.
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- Research has shown that natural substances like selenium (Se) and lycopene may help reduce male infertility caused by varicocele, with each having a positive effect individually.
- In a study with male rats, those with varicocele showed decreased testosterone levels, testicular weight, and structural damage in testicular tissues, indicating infertility issues.
- When treated with Se, lycopene, or both, the rats demonstrated significant improvements in testis weight, testosterone levels, and overall testicular health, suggesting that combining these nutrients could be a potential therapeutic approach alongside surgery, although more research is needed.
Article Synopsis
- Increased production of reactive oxygen species (ROS) during cellular injury can lead to conditions like cancer, with glutathione (GSH) playing a crucial role in restoring cellular balance.
- A review of clinical and preclinical data revealed that GSH can interact with anti-cancer drugs, either reducing their harmful effects or, conversely, increasing their toxicity through bioactivation.
- While many cancer patients self-prescribe GSH to mitigate treatment side effects, there’s limited scientific backing for its effectiveness, and it's recommended to use GSH only under medical guidance for safe administration.
Article Synopsis
- * Research has identified several mechanisms of Cd-induced kidney injury, including inflammation, programmed cell death, and hormonal imbalances, which can contribute to skeletal fragility as well.
- * Emerging evidence suggests that dietary factors, particularly nutraceuticals found in the Mediterranean diet, may offer safe therapeutic options to counteract Cd’s harmful effects and improve CKD management.
Multiple myeloma (MM) is malignant disease characterized by the clonal proliferation of plasma cells in the bone marrow, leading to anemia, immunosuppression, and other symptoms, that is generally hard to treat. In MM, the immune system is likely exposed to neoplasia-associated neoantigens for several years before the tumor onset. Different types of neoantigens have been identified.
View Article and Find Full Text PDFVaricocele is one of the main causes of infertility in men, thus representing an important clinical problem worldwide. Inflammation contributes mainly to its pathogenesis, even if the exact pathophysiological mechanisms that correlate varicocele and infertility are still unknown. In addition, oxidative stress, apoptosis, hypoxia, and scrotal hyperthermia seem to play important roles.
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- Polydeoxyribonucleotide (PDRN), derived from salmon trout sperm, and selenium (Se), a trace dietary element, were studied for their effects on testicular damage after ischemia-reperfusion (I/R) in rats.
- The I/R condition increased harmful factors like HIF-1α and malondialdehyde (MDA) while decreasing testosterone and other protective factors in the testicles.
- Treatment with either PDRN or Se improved testicular health, but their combination provided the best results, suggesting they could help mitigate damage caused by conditions like varicocele.
The transition from premenopause to postmenopause is associated with the development of multiple elements of Metabolic Syndrome (MetS) [...
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- * Recent research focuses on how Cd causes damage to testicular structure and function, highlighting its effects like oxidative stress, inflammation, and cell death, with an urgent need for new treatments.
- * A potential solution involves dietary changes and nutraceuticals, especially those rich in fruits, beans, vegetables, and grains from the Mediterranean diet, which could help prevent or reduce Cd-related testicular injury.
Article Synopsis
- Cadmium (Cd) is harmful to public health due to its long-lasting presence in the body, primarily affecting the kidneys.
- The study tested the protective effects of bergamot juice extract, curcumin, and resveratrol on mice exposed to cadmium, showing that these substances can improve kidney health significantly.
- Results indicated that combined treatment with all three nutraceuticals effectively normalized kidney function markers after cadmium exposure, suggesting a potential new approach for protecting against kidney damage from environmental toxins.
Article Synopsis
- Cadmium chloride (CdCl) negatively impacts testicular structure and function, increasing certain inflammatory and apoptotic markers while decreasing anti-apoptotic signals in mice.
- The study tested the protective effects of nutraceuticals, specifically bergamot juice extract (BJe), curcumin (Cur), and resveratrol (Re), on CdCl-induced testicular dysfunction over a 14-day period.
- Results showed that all three nutraceuticals significantly improved testicular health, with combinations of them bringing parameters back to near control levels, suggesting potential protective benefits against environmental toxins.
Varicocele is an age-related disease with no current medical treatments positively impacting infertility. Toll-like receptor 4 (TLR4) expression is present in normal testis with an involvement in the immunological reactions. The role of peroxisome proliferator-activated receptor-α (PPAR-α), a nuclear receptor, in fertility is still unclear.
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- Bioactive compounds like selenium and Polydeoxyribonucleotide (PDRN) are being studied for their potential to treat male infertility related to varicocele, focusing on the NLRP3 inflammasome's role.
- An experimental study on male rats showed that varicocele led to lower testosterone levels and increased apoptosis in testicular cells, alongside structural damage.
- Treatment with PDRN alone improved testicular health, but the combination of Se and PDRN showed the most significant benefits, indicating their potential as a therapeutic strategy along with surgical intervention.
Article Synopsis
- Varicocele is a major cause of male infertility, linked to oxidative stress and cell death, impacting prognosis.
- In an experimental study on male rats, those with varicocele showed reduced testosterone, testes weight, and increased cell apoptosis after surgery.
- Lycopene treatment improved testosterone levels, testes weight, and reduced markers of oxidative damage and cell death, suggesting it could be a potential natural treatment for varicocele and related infertility.
Article Synopsis
- Cadmium (Cd) is harmful to the thyroid gland, prompting a study on the protective effects of myo-inositol (MI) and seleno-L-methionine (Se) in mice exposed to Cd chloride (CdCl).
- Mice were divided into groups and treated with either CdCl alone or in combination with MI or Se over 14 days; the effects were measured by examining thyroid tissue for structural changes and inflammatory markers.
- Results showed that both MI and Se helped restore thyroid function, with the combination of MI and Se being particularly effective, outperforming resveratrol, suggesting these supplements could protect the thyroid from Cd damage.
Cadmium (Cd) induces functional and morphological changes in kidney. Therefore, the effects of a natural nutraceutical antioxidant, myo-inositol (MI), were evaluated in mice kidneys after Cd challenge. Twenty-eight C57 BL/6 J mice were divided into these groups: 0.
View Article and Find Full Text PDFCadmium (Cd) is a harmful heavy metal, which causes severe brain damage and neurotoxic effects. Polydeoxyribonucleotide (PDRN) stimulates adenosine A receptor, thus contrasting several deleterious mechanisms in course of tissue damages. We aimed to investigate the possible neuroprotective effect of PDRN in a murine model of Cd-induced brain toxicity.
View Article and Find Full Text PDFVibratory angioedema is a rare form of physical urticaria, hereditary or acquired, which occurs at body sites exposed to vibrations. Pathogenic mechanisms of disease are not completely clear and, consequently, current pharmacological treatment is sometimes unsatisfactory. We report the case of a horn player affected by acquired vibratory angioedema, relapsing after prolonged use of the instrument and resistant to systemic antihistamines and corticosteroids, which successfully responded to therapy with low doses of amitriptyline and bromazepam.
View Article and Find Full Text PDFObjective: Treatment for traumatic brain injury remains elusive despite compelling evidence from animal models for a variety of therapeutic targets. Melanocortins have established neuroprotective effects against experimental ischemic stroke. We investigated whether melanocortin treatment of traumatic brain injury induces neuroprotection and promotes functional recovery.
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