Publications by authors named "Heqin Guan"
Objectives: Human leukocyte antigen G (HLA-G) plays a crucial role in pregnancy. Pregnancy loss (PL) is caused by a variety of causes, such as fetal chromosomal abnormalities, maternal hypertension and diabetes, immune causes, spontaneous immune diseases, infections, unknown causes, etc. This study reports on the association of fetal HLA-G 3'UTR polymorphisms and diplotypes with chromosomally abnormal fetuses (CAF) or unexplained pregnancy loss (UPL).
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- PCOS is a common endocrine disorder in women of reproductive age and our study investigates the pregnancy outcomes of embryo transfers in women with this condition, particularly focusing on the impact of high androgen levels on endometrial receptivity.
- A retrospective study involving 2714 infertile women and 452 women with PCOS found that pregnancy outcomes, including implantation and live birth rates, were significantly lower in women with PCOS after fresh embryo transfers, despite pretreatment.
- The research indicates that higher testosterone levels on the day of embryo transfer negatively affect pregnancy rates and the expression of important endometrial markers, suggesting that even with treatment, endometrial receptivity remains impaired in women with PCOS.
Objectives: A screening model for prediction of small-for-gestational-age (SGA) neonates (SGAp) was established by logistic regression using ultrasound data and maternal factors (MF). We aimed to evaluate the ability of SGAp as well as abdominal circumference (AC) and estimated fetal weight (EFW) measurements to predict SGA neonates at 33-39 weeks' gestation.
Methods: This retrospective study evaluated 5298 singleton pregnancies that had involved three ultrasound examinations at 21-27, 28-32, and 33-39 weeks.
Article Synopsis
- * Key assessments included mtDNA copies, mitochondrial activity, ATP content, and cytoskeleton integrity, showing significant differences between COH and NC, as well as between IVM and NC in various measures.
- * The findings suggest that COH and IVM can damage mitochondria, potentially explaining issues like low IVF efficiency and high embryonic loss rates associated with these treatments.
Mitochondrial metabolic capacity and DNA replication have both been shown to affect oocyte quality, but it is unclear which one is more critical. In this study, immature oocytes were treated with FCCP or ddC to independently inhibit the respective mitochondrial metabolic capacity or DNA replication of oocytes during in vitro maturation. To differentiate their roles, we evaluated various parameters related to oocyte maturation (germinal vesicle break down and nuclear maturation), quality (spindle formation, chromosome alignment, and mitochondrial distribution pattern), fertilization capability, and subsequent embryo developmental competence (blastocyst formation and cell number of blastocyst).
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