Publications by authors named "Heon Yoo"

The role of acetylated apurinic/apyrimidinic endonuclease 1/redox factor 1 (APE1/Ref-1) in ovarian cancer remains poorly understood. Therefore, this study aimed to investigate the combined effect of recombinant human APE1/Ref-1 (rhAPE1/Ref-1) and aspirin (ASA) on two ovarian cancer cells, PEO-14, and CAOV3. The viability and apoptosis of ovarian cancer cells treated with rhAPE1/Ref-1 or ASA were assessed.

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To compare the outcomes of single-port access laparoscopic surgery (SPALS) and single-site robotic surgery (SSRS) for benign gynecological diseases, we retrospectively analyzed clinical data from 367 patients who underwent gynecologic surgery at Sejong Chungnam National University Hospital from October 2020 to December 2023. : Of these 367 patients, 197 underwent SPALS, whereas 170 underwent SSRS. The SPALS group comprised 87 patients who underwent hysterectomy; 107, adnexal surgery (cystectomy: 44, adnexectomy: 63); and 1 myomectomy.

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Background: Leptomeningeal metastasis (LM) is a devastating complication of cancer that is difficult to treat. Thus, early diagnosis is essential for LM patients. However, cerebrospinal fluid (CSF) cytology has low sensitivity, and imaging approaches are ineffective.

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The use of neoadjuvant chemotherapy (NAC) as a first-line therapy for advanced high-grade serous ovarian carcinoma (HGSOC) has increased. However, several studies have reported NAC-induced platinum resistance. This study aimed to evaluate the predictive impact of clinical factors on chemotherapy response score (CRS) and to select patients who would respond well to NAC.

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  • The genus Streptococcus includes both harmless and harmful bacteria that naturally reside in the human body, particularly in the female genital tract (FGT), where there are two main groups: the pathogenic group B Streptococci (GBS) and the commensal viridans group streptococci (VGS).
  • A novel strain named Streptococcus sp. K0074 was isolated from a vaginal swab of an endometrial cancer patient and showed potential as a commensal member of the VGS, specifically within the mitis subgroup.
  • This strain produced a bacteriocin-like substance that can inhibit the growth and biofilm formation of the harmful bacterium MRSA, suggesting it may play a significant
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  • A nationwide survey in Korea was conducted to investigate the practices of gynecologic oncologists regarding peritonectomy techniques (total vs. selective) for treating advanced ovarian/fallopian tube cancer.
  • Results showed that 98.9% and 93.8% of the oncologists performed selective parietal peritonectomy (SPP) during primary and interval debulking surgeries, while only 4.9% performed total parietal peritonectomy (TPP).
  • Concerns about patient morbidity and unclear benefits of TPP were the main reasons for its low usage, indicating a need for further studies to assess TPP's feasibility before initiating a larger clinical trial.
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  • The study focuses on chordoma, a rare and aggressive tumor of the cervical spine, highlighting its resistance to standard treatments and the necessity of surgical intervention.
  • Conducted across 7 medical centers, the research analyzes data from 45 patients over a median of 52 months, tracking local recurrence and survival outcomes.
  • Results show that while age significantly influences mortality rates, the method of tumor removal and additional treatments do not have a considerable impact on controlling the disease or improving survival rates.
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  • * Patients who underwent surgery had higher initial lactic acid levels and shock indexes, indicating more severe conditions, while also exhibiting lower heart rates and body temperatures.
  • * Surgical patients had worse overall outcomes, with specific predictors for surgery identified, and the subgroup analysis revealed that delayed surgical interventions correlated with higher rates of severity in conditions like uterine atony and hysterectomy.
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Leptomeningeal metastasis (LM) is a common and fatal complication of advanced non-small cell lung cancer (NSCLC) caused by the spread of malignant cells to the leptomeninges and cerebrospinal fluid (CSF). While intra-CSF methotrexate (MTX) chemotherapy can improve prognosis, eventual MTX resistance deters continued chemotherapy. Recent studies have shown that increased miRNA-21 (miR-21) expression in the CSF of patients with LM after intraventricular MTX-chemotherapy is associated with poor overall survival; however, the molecular mechanisms underlying this resistance are poorly understood.

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Purpose: This study aimed to evaluate the symptomatic response and side effects of ventriculolumbar perfusion (VLP) methotrexate chemotherapy with a low perfusion rate in patients with leptomeningeal metastasis.

Methods: Patients in a single-arm, two-stage phase II trial based on Simon's minimax design received VLP with a reduced (15 cc/h) perfusion rate with the purpose of decreasing constitutional side effects such as nausea/vomiting, insomnia, and confusion. The primary outcome was control of increased intracranial pressure (ICP).

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Background And Objectives: Leptomeningeal metastases (LMs) are neoplasms that proliferate to membranes lining the brain and spinal cord. Intra-CSF methotrexate (MTX) chemotherapy is a prevalent treatment option. However, resultant long-term neurotoxicity can lead to irreversible disseminated necrotizing leukoencephalopathy (DNL).

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  • The study focuses on primary CNS tumors (PCNSTs) in South Korea, highlighting their significant impact on cancer mortality and the need for accurate epidemiologic data.
  • In 2020, over 15,500 new cases of PCNSTs were reported, showing an increase in glioblastoma and lymphoma diagnoses, linked to the aging population.
  • The findings stress the importance of teamwork in addressing the rising challenges of PCNST incidence related to demographic changes.
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The evolutionary trajectory of glioblastoma (GBM) is a multifaceted biological process that extends beyond genetic alterations alone. Here, we perform an integrative proteogenomic analysis of 123 longitudinal glioblastoma pairs and identify a highly proliferative cellular state at diagnosis and replacement by activation of neuronal transition and synaptogenic pathways in recurrent tumors. Proteomic and phosphoproteomic analyses reveal that the molecular transition to neuronal state at recurrence is marked by post-translational activation of the wingless-related integration site (WNT)/ planar cell polarity (PCP) signaling pathway and BRAF protein kinase.

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Objective: To evaluate the usefulness of a cranial implantable chemoport, the H-port, as an alternative to the Ommaya reservoir for intraventricular chemotherapy/cerebrospinal fluid (CSF) access in patients with leptomeningeal metastasis (LM).

Methods: One hundred fifty-two consecutive patients with a diagnosis of LM and who underwent H-port installation between 2015 and 2021 were evaluated. Adverse events associated with installation and intraventricular chemotherapy, and the rate of increased intracranial pressure (ICP) control via the port were evaluated for safety and efficacy.

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Endometriosis, which is the presence of endometrial stroma and glands outside the uterus, is one of the most frequently diagnosed gynecologic diseases in reproductive women. Patients with endometriosis suffer from various pain symptoms such as dysmenorrhea, dyspareunia, and chronic pelvic pain. The pathophysiology for chronic pain in patients with endometriosis has not been fully understood.

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Unlabelled: Glioblastoma is the most common type of malignant primary brain tumor and displays highly aggressive and heterogeneous phenotypes. The transcription factor STAT3 has been reported to play a key role in glioblastoma malignancy. Thus, discovering targets and functional downstream networks regulated by STAT3 that govern glioblastoma pathogenesis may lead to improved treatment strategies.

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Background Aims: Human telomerase reverse transcriptase (hTERT) is an attractive target for anti-cancer therapies. We developed an effective method for generating hTERT-specific CD8 T cells (hTERT-induced natural T cells [TERTiNTs]) using peripheral blood mononuclear cells (PBMCs) from patients with solid cancers and investigated their feasibility and safety.

Methods: This was a single-center phase 1 trial using a 3 + 3 dose escalation design to evaluate six dose levels of TERTiNTs.

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Purpose: Glioblastoma (GBM) has a poor prognosis after standard treatment. Recently, metformin has been shown to have an antitumor effect on glioma cells. We performed the first randomized prospective phase II clinical trial to investigate the clinical efficacy and safety of metformin in patients with recurrent or refractory GBM treated with low-dose temozolomide.

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Surgical debridement is an essential step in treating complex facial lacerations (CFL). As the CFL severity increases, conventional surgical debridement (CSD) of wound edges becomes difficult and may be insufficient. Because the severity and shape of each CFL vary, it is necessary to tailor the customized pre-excisional design, that is, tailored surgical debridement (TSD), for each case before performing surgical debridement.

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  • Diffuse infiltration in glioblastoma (GBM) leads to treatment resistance and recurrence, highlighting the need for targeted therapies against GBM stem-like cells (GSCs) responsible for invasion.
  • The study identifies Insulin-like Growth Factor-Binding Protein 5 (IGFBP5) as a key ligand for the ROR1 receptor, which plays a significant role in GSC invasion and tumor development.
  • Utilizing CRISPR/Cas9-based gene editing delivered via targeted nanocapsules, researchers showed promising results in inhibiting GSC invasion and enhancing survival in tumor-bearing mice, positioning the IGFBP5-ROR1/HER2-CREB pathway as a potential therapeutic target for GBM.*
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Objective: Our objective is to analyze the occurrence, clinical course and risk factors for glioma patients with leptomeningeal metastasis (LM) according to different metastasis patterns and clinical variables.

Methods: We retrospectively reviewed data from 376 World Health Organization (WHO) grade II-IV adult glioma patients who were treated in the National Cancer Center from 2001 to 2020. Patients who underwent surgery at other institutions, those without initial images or those with pathologically unconfirmed cases were excluded.

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Most high-grade serous ovarian carcinomas (HGSOCs) involving the peritoneum are aggressive. Epidermal growth factor receptor 2 (HER2) is aberrantly activated in a variety of solid cancers. The HER2 status of a tumor is based on cytoplasmic membrane staining of an intracellular domain (ICD)-specific HER2 antibody.

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Background: Intra-cerebrospinal fluid (CSF) chemotherapy for leptomeningeal metastasis (LM) can be delivered intraventricularly via an Ommaya reservoir. However, hydrocephalus associated with LM can interfere with chemotherapeutic drug distribution, and ventriculoperitoneal shunts can prevent drug distribution to the extra-ventricular CSF space. This study examined the feasibility of combining a lumboperitoneal (LP) shunt with an Ommaya reservoir to both control intracranial pressure and allow for intraventricular chemotherapy.

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The COVID 19 pandemic is far from over, and vaccines remain important tool for fighting the disease. As the preventive effects of the COVID-19 vaccine emerges, it is likely that the perception of importance and safety of vaccines have a positive effect on the acceptance of other vaccines. However, it is still unclear how COVID-19 pandemic has affected the general vaccination perception and acceptance.

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The present study aimed to evaluate whether the cerebrospinal fluid (CSF) neurofilament light chain (NfL) is a potential prognostic marker for patients with leptomeningeal metastasis (LM). NfL levels were measured in CSF using a single-molecule array assay. A total of 42 patients with LM who were treated with ventriculo-lumbar perfusion (VLP) chemotherapy and had available stored CSF samples from the lumbar subarachnoid space before VLP chemotherapy were included in the present study, in order to investigate the prognostic value of CSF NfL.

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