Publications by authors named "Heo G"
Introduction: Evidence on the pre-clinical and clinical performance of internationally trained dental students compared with domestic students and competency standards is limited. The aim of this study was to compare, relatively and normatively, the psychomotor skills of domestic and internationally trained dental students who participated in the same pre-clinical, 9-week, fixed prosthodontics course.
Materials And Methods: Course grades were collected for a total of 224 domestic and 66 internationally trained dental students between 2014 and 2020.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint swelling, pain, and bone remodeling. We previously reported that autotaxin (ATX) deficiency disrupts lipid rafts in macrophages. Lipid raft disruption results in the dysregulation of RANK signaling, which is crucial for osteoclastogenesis and the pathogenesis of RA.
View Article and Find Full Text PDFKey Points: A higher medication burden was associated with a higher risk of adverse events in patients receiving maintenance hemodialysis. Medication burden can serve as a clinically relevant risk indicator for cardiovascular events and all-cause death in patients on maintenance hemodialysis.
Background: A high medication burden is associated with adverse outcomes.
Objectives: To compare the biomechanics of labial and lingual fixed orthodontic treatment options for a simulated curve of Spee malocclusion.
Materials And Methods: An in vitro electromechanical orthodontic simulator was used to measure the three-dimensional forces and moments on each tooth of a mandibular arch. Labial and lingual brackets, both with 0.
Article Synopsis
- Metabolic-dysfunction associated steatohepatitis (MASH) is linked to conditions like obesity and diabetes, leading to liver problems and cardiovascular disease, but identifying it in patients can be difficult.* -
- Researchers developed targeted peptide radiotracers for PET imaging to visualize changes in macrophage populations in the liver of mice with MASH, observing a decrease in resident macrophages and an increase in recruited ones during disease progression.* -
- The study found a strong correlation between the PET imaging results and tissue analysis, suggesting that these radiotracers could be useful for non-invasive diagnostics and monitoring of MASH in humans.*
Objective: Growing demand for embryo transfer is steadily expanding and further studies on in vitro fertilization of cattle. To assess the effect of calcium lactate by replacing Tyrode's Albumin Lactate Pyruvate (TALP) medium composition during fertilization and embryonic development.
Methods: Sodium lactate and CaCl2 were replaced with 2.
Receptor kinase (RK) families process information from small molecules, short peptides, or glycan ligands to regulate core cellular pathways in plants. To date, whether individual plant RKs are capable of processing signals from distinct types of ligands remains largely unexplored. Addressing this requires the discovery of structurally unrelated ligands that engage the same receptor.
View Article and Find Full Text PDFArticle Synopsis
- ABO-incompatible kidney transplantation (KT) is increasingly used to address organ shortages, but high levels of anti-ABO antibodies can hinder successful transplantation despite existing desensitization methods.
- Eculizumab was used as an additional treatment to help patients with very high anti-ABO antibodies who did not respond to standard therapies, showing improvements in kidney function and antibody levels after transplant.
- The study indicates that short-term eculizumab treatment may effectively support ABOi KT patients by maintaining stable kidney function and reducing antibody levels, even in cases previously deemed challenging.
Article Synopsis
- Pulmonary fibrosis involves immune cell activity and fibroblast expansion, with CCR2+ monocytes playing a key role in its progression.
- In mouse models, both an oral CCR2 inhibitor and the antifibrotic drug nintedanib reduced lung CCR2+ cells and fibrosis, indicating potential for using CCR2 inhibition as a treatment strategy.
- CCR2-PET imaging could serve as a valuable tool for monitoring treatment responses and guiding patient management in pulmonary fibrosis.
Article Synopsis
- * The isolated virus from the cats and raw food belonged to the HPAI A(H5N1) clade 2.3.4.4b, showing similarities to previously isolated viruses in Korea from November 2022.
- * Infected cats exhibited severe systemic lesions and harbored mutations indicating adaptation to mammals, leading to symptoms and death from consuming contaminated raw meat.
Article Synopsis
- The study investigates the link between inflammation and tissue fibrosis in human cardiac diseases, revealing unique fibroblast populations that contribute to heart dysfunction.
- Researchers used advanced techniques on heart samples to uncover these fibroblast types and their relationship with immune cells, specifically CCR2 macrophages, in promoting fibrosis through IL-1β signaling.
- By blocking IL-1β signaling, the study demonstrated reduced fibrosis and improved heart function, suggesting that targeting inflammation could be a promising approach for treating cardiac fibrosis.
Background: Evidence on the effectiveness of pulmonary artery catheters (PACs) in cardiac surgery is scarce.
Research Question: Does perioperative PAC use decrease 1-year all-cause mortality in patients undergoing cardiac surgery?.
Study Design And Methods: This nationwide, population-based cohort study included all adult patients who underwent cardiac surgery in Korea between January 2011 and December 2020, using a Korean health insurance claim database.
Article Synopsis
- Monocytes play a crucial role in atherosclerosis by turning into macrophages when they migrate to plaques, and this study explores how their glucose metabolism influences their behavior and contribution to the disease.
- Researchers found that higher serum glucose levels are linked to increased monocyte numbers, while restricted diets hinder monocytes from switching energy sources, which reduces their presence in the blood.
- The study highlights that glucose metabolism is vital for maintaining specific monocyte characteristics and functions, but inhibiting glucose uptake alone doesn't prevent atherosclerosis, likely because the remaining monocytes become more migratory.
In this high-throughput proteomic study of autosomal dominant Alzheimer's disease (ADAD), we sought to identify early biomarkers in cerebrospinal fluid (CSF) for disease monitoring and treatment strategies. We examined CSF proteins in 286 mutation carriers (MCs) and 177 non-carriers (NCs). The developed multi-layer regression model distinguished proteins with different pseudo-trajectories between these groups.
View Article and Find Full Text PDFBackground: Immune checkpoint inhibitor (ICI) usage has resulted in immune-related adverse events in patients with cancer, such as accelerated atherosclerosis. Of immune cells involved in atherosclerosis, the role of CCR2+ (CC motif chemokine receptor 2-positive) proinflammatory macrophages is well documented. However, there is no noninvasive approach to determine the changes of these cells in vivo following ICI treatment and explore the underlying mechanisms of immune-related adverse events.
View Article and Find Full Text PDFObjectives: This study aimed to evaluate the reliability and accuracy of an intraoral ultrasound (US) device to evaluate alveolar bone by comparing it between different raters and to microCT (µCT) measurements.
Methods: 38 teeth distributed across three human cadavers were prepared by placing two notches on the facial enamel surface. The maxillary and mandibular teeth were imaged with a custom-designed intraoral 20 MHz ultrasound and µCT with 0.
Article Synopsis
- A study explored the link between dietary magnesium intake and the development of chronic kidney disease (CKD) in adults with normal kidney function, involving a large cohort from the UK Biobank.
- Results indicated that lower dietary magnesium intake correlated with a higher incidence of CKD, where individuals with the lowest intake showed progressively greater risk.
- The findings suggest that maintaining adequate magnesium levels could be important for kidney health, as lower intake was associated with increased CKD risk during the follow-up period.
The analysis of membrane vesicles at the nanoscale level is crucial for advancing the understanding of intercellular communication and its implications for health and disease. Despite their significance, the nanoscale analysis of vesicles at the single particle level faces challenges owing to their small size and the complexity of biological fluids. This new vesicle analysis tool leverages the single-molecule sensitivity of super-resolution microscopy (SRM) and the high-throughput analysis capability of deep-learning algorithms.
View Article and Find Full Text PDFIntroduction: Numerous studies of school-based smoking prevention programs (SSPPs) exist; however, most have been conducted from the students' perspective, and insufficient research has explored teachers' perceptions. Our study aimed to identify factors affecting overall satisfaction and operational status from the perspective of teachers participating in the SSPP.
Methods: This is a cross-sectional study analyzing data from a survey regarding the operation of an SSPP conducted by the Korea Health Promotion Institute in 2022.
Article Synopsis
- CCR2 is a receptor found on certain inflammatory monocytes and macrophages that play a role in heart failure, distinguishing them from other myeloid cells in the heart.
- Researchers tested a specialized imaging probe (Cu-DOTA-ECL1i) that can identify these CCR2-expressing cells for potential use in imaging the human heart.
- The probe showed increased uptake in patients who had suffered an acute myocardial infarction, primarily in the damaged area of the heart, and this was linked to poor heart muscle movement, suggesting it could help visualize inflammation in heart injuries.
Sex and age are major risk factors for chronic diseases. Recent studies examining age-related molecular changes in plasma provided insights into age-related disease biology. Cerebrospinal fluid (CSF) proteomics can provide additional insights into brain aging and neurodegeneration.
View Article and Find Full Text PDFAdequacy of Dialysis and Incidence of Atrial Fibrillation in Patients Undergoing Hemodialysis.
Circ Cardiovasc Qual Outcomes
August 2024
Background: Atrial fibrillation (AF) can lead to stroke, heart failure, and mortality and has a greater prevalence in dialysis patients than in the general population. Several studies have suggested that uremic toxins may contribute to the development of AF. However, the association between dialysis adequacy and incident AF has not been well established.
View Article and Find Full Text PDFHighly pathogenic avian influenza H5N6 and H5N1 viruses of clade 2.3.4.
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