Publications by authors named "Henyun Shi"
Mitochondria transfer is a recently described phenomenon in which donor cells deliver mitochondria to acceptor cells. One possible consequence of mitochondria transfer is energetic support of neighbouring cells; for example, exogenous healthy mitochondria can rescue cell-intrinsic defects in mitochondrial metabolism in cultured ρ cells or Ndufs4 peritoneal macrophages. Exposing haematopoietic stem cells to purified mitochondria before autologous haematopoietic stem cell transplantation allowed for treatment of anaemia in patients with large-scale mitochondrial DNA mutations, and mitochondria transplantation was shown to minimize ischaemic damage to the heart, brain and limbs.
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- Ahed is a newly identified gene in haematopoiesis that plays a crucial role in blood cell development, discovered through screening mutant embryonic stem cells.
- Conditional knockout of Ahed leads to severe anemia and prenatal death, as its absence hampers the ability of haematopoietic cells to regenerate in living organisms.
- Deletion of Ahed disrupts multiple biological pathways in adult mice and is linked to mutations found in cancer patients, highlighting its importance in both normal blood development and potential involvement in cancers.
Signal-transducing adaptor protein-2 (STAP-2) was discovered as a C-FMS/M-CSFR interacting protein and subsequently found to function as an adaptor of signaling or transcription factors. These include STAT5, MyD88 and IκB kinase in macrophages, mast cells, and T cells. There is additional information about roles for STAP-2 in several types of malignant diseases including chronic myeloid leukemia, however, none have been reported concerning B lineage lymphocytes.
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