Publications by authors named "Henryk Zrubek"
Background: Studies consistently reveal downregulation of major histocompatibility complex (MHC)-I molecules or/and selective loss of individual MHC-I alleles and upregulation of MHC-II molecules in the areas of cervical intraepithelial neoplasia (CIN) and in cervical cancers. In vitro studies demonstrated the interferon-gamma (IFN-gamma) potential of MHC class I and II molecule upregulation followed by increased cytolytic response against some cervical cancer cell lines.
Aim Of The Study: In vivo assessment of the correlation between regression/persistence state of CIN and the IFN-gamma-induced changes in both class of selected MHC molecule expression.
Objectives: The immediate results of interferon gamma (IFN-gamma) treatment in the management of cervical intraepithelial neoplasia (CIN) have been described. However, little is known of the long-term results of this conservative treatment and we aimed to assess them.
Methods: We conducted a 5-year follow-up of 13 women with either complete response to intracervical administration of 6,000,000 IU of IFN-gamma (remission from human papilloma virus-induced CIN occurred in nine cases) or partial response (a lower grade of CIN and/or HPV clearance was achieved in four cases).
Objectives: The aim of the study was the evaluation of the way of diagnostic and therapeutic management in case of neoplasm of the reproductive organ in pregnant women treated in the I Clinic of the Operative Gynaecology in Lublin.
Material And Methods: In the years 1990-2000 in the I Clinic of the Operative Gynaecology in Lublin, 3556 operations were performed. In 9 cases the operations were carried out because of the neoplasm of the reproductive organ diagnosed in the course of pregnancy.