[To know more about the Prader-Willi syndrome. Multidisciplinary support].

Prader-Willi syndrome, induced by a loss of function of paternal genes in the subcentrometric region of the chromosome 15 (q11.2q13), is a complex neurodevelopmental disorder with characteristic obesity resulting from hyperphagia. In addition behavioural disturbancies with obsessive-compulsive features, aggression, temper tantrums included, are relatively frequently seen and they often require psychiatric intervention.

[To know more about the Prader-Willi syndrome. Diagnosis].

Prader-Willi syndrome, induced by a function changes of paternal genes in the subcentrometric region of the chromosome 15 (q11.2q13), is the most common genetic cause of obesity resulting from hyperphagia. Behavioural disturbancies with compulsions in which psychiatric interventions are necessary, are relatively frequently seen.

[May the dialogue between genes and environmental factors modify the behavioural phenotype of Rett syndrome and others?].

Formation of a phenotype during development of the human being may result from a specific dialogue between genes and environmental factors. Expression of particular genes is controlled not only on the transcriptional level but also on the level of accessibility of genetic information through the influence for remodelling of chromatin. We characterized Rett syndrome and its molecular basis as an example of the relation between genes and environment and their influence on epigenetic processes determining the gene expression.

Chronic neurotic and depressive disorders as posttraumatic reactions in the Polish Siberians.

The study "Chronic depressive and neurotic disorders as posttraumatic reactions in the Polish Siberians" focuses on the effect of traumatic factors in the form of chronic distress on mental and physical state. Test results confirmed earlier clinical observations of depressive and neurotic disorders, and the Posttraumatic Stress Disorder (PTSD). PTSD is a reaction associated with an event a threat to life or to physical integrity, during with a person experience sever distress.