Noninvasive imaging with thallium-201 scintigraphy may not correlate with survival in patients with osteosarcoma.

Background: Histologic response to preoperative chemotherapy is a strong prognostic factor for osteosarcoma (OS). Thallium-201 (Tl-201) scintigraphic response to initial chemotherapy has previously been described as a predictor of histologic response. In the current study, the authors re-examined a series of patients studied using Tl-201 scintigraphy to determine the correlation between changes observed on Tl-201 scintigraphy and event-free survival (EFS).

Incidental finding of focal FDG uptake in the bowel during PET/CT: CT features and correlation with histopathologic results.

Objective: The purpose of this study was to identify and characterize the clinically significant lesions associated with incidental detection of focal uptake of (18)F-FDG in the bowel at PET/CT.

Materials And Methods: Among 2,250 consecutively registered patients with various nongastrointestinal malignant diseases who underwent FDG PET/CT as part of their care, patients with the incidental finding of focal bowel uptake of FDG were included in the study. All patients underwent an endoscopic or surgical procedure for characterization of the lesions.

Chronic thyroiditis in patients with advanced breast carcinoma: metabolic and morphologic changes on PET-CT.

Purpose: To investigate clinical implications of FDG uptake in the thyroid glands in patients with advanced breast carcinoma by comparing metabolic and morphologic patterns on positron emission tomography (PET)/computed tomography (CT).

Methods: The institutional review board waived the requirement for informed consent. A retrospective analysis was performed in 146 women (mean age 54 years) with advanced breast carcinoma who received systemic treatment.

Bone metastases in patients with metastatic breast cancer: morphologic and metabolic monitoring of response to systemic therapy with integrated PET/CT.

Purpose: To retrospectively compare morphologic and metabolic changes in bone metastases in response to systemic therapy in patients with metastatic breast cancer (MBC) with integrated positron emission tomography (PET)/computed tomography (CT).

Materials And Methods: The institutional review board waived the requirement for informed consent and approved this HIPAA-compliant study. A retrospective analysis was performed with 102 women (mean age, 55 years) with MBC who received systemic treatment.

Thymic extension in the superior mediastinum in patients with thymic hyperplasia: potential cause of false-positive findings on 18F-FDG PET/CT.

Objective: Although 18F-FDG PET/CT is now well established as an accurate method for the staging and restaging of various cancers, it is also well recognized that many false-positive results can occur. One such false-positive is activity within the superior extent of the thymus in the superior mediastinum.

Conclusion: We reviewed all PET/CT examinations performed in children and young adults under the age of 20 years at our institution over a 2-month period.

Diagnostic accuracy and prognostic value of 18F-FDG PET in Hürthle cell thyroid cancer patients.

Unlabelled: Hürthle cell carcinoma is an uncommon and occasionally aggressive differentiated thyroid cancer associated with increased mortality compared with other differentiated thyroid malignancies. Because it generally has lower iodine avidity, 18F-FDG PET has been suggested as a more accurate imaging modality. However, there is limited information with regard to the true diagnostic accuracy and prognostic value of 18F-FDG PET in this disease.

18F-FDG PET/CT for detecting nodal metastases in patients with oral cancer staged N0 by clinical examination and CT/MRI.

Unlabelled: (18)F-FDG PET has a high accuracy in staging head and neck cancer, but its role in patients with clinically and radiographically negative necks (N0) is less clear. In particular, the value of combined PET/CT has not been determined in this group of patients.

Methods: In a prospective study, 31 patients with oral cancer and no evidence of lymph node metastases by clinical examination or CT/MRI underwent (18)F-FDG PET/CT before elective neck dissection.

Clinical value of combined positron emission tomography/computed tomography imaging in the interpretation of 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography studies in cancer patients.

Background: Positron emission tomography (PET)/computed tomography (CT) is a new imaging modality that provides exact coregistration of anatomic and metabolic data. We have investigated to what degree this new technique might affect the interpretation of PET images in a nonselected group of consecutive cancer patients, reflecting routine condition in a busy cancer center.

Methods: Whole-body 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-PET and PET/CT fusion image sets were compared in 100 consecutive, nonselected patients: 21 with head and neck cancer, 39 with chest malignancies, and 40 with malignancies of the abdomen and pelvis.

Intensity of 18fluorodeoxyglucose uptake in positron emission tomography distinguishes between indolent and aggressive non-Hodgkin's lymphoma.

Purpose: (18)Fluorodeoxyglucose positron emission tomography (FDG PET) is widely used for the staging of lymphoma. We investigated whether the intensity of tumor FDG uptake could differentiate between indolent and aggressive disease.

Materials And Methods: PET studies of 97 patients with non-Hodgkin's lymphoma who were untreated or had relapsed and/or persistent disease and had not received treatment within the last 6 months were analyzed, and the highest standardized uptake value (SUV) per study was recorded.

Clinical significance of unexplained abnormal focal FDG uptake in the abdomen during whole-body PET.

Objective: FDG PET is frequently used as part of the diagnostic workup in cancer patients. Visualization of radiotracer-avid foci suggests the presence of malignant disease. Unexplained focal FDG accumulation in the abdomen is sometimes noted, but the clinical significance of this finding is unknown.

Positron emission imaging of head and neck cancer, including thyroid carcinoma.

Most positron emission tomography (PET) imaging studies in head and neck cancer are performed using the radiotracer 18-fluorodeoxyglucose ((18)FDG). PET with FDG has become a standard clinical imaging modality in patients with head and neck cancer. It contributes valuable information in localizing a primary tumor in patients with neck nodal metastases from an unknown primary, in the staging of primary head and neck cancer, and in the detection of recurrent disease.

Clinical implications of different image reconstruction parameters for interpretation of whole-body PET studies in cancer patients.

Unlabelled: The standardized uptake value (SUV) is the most commonly used parameter to quantify the intensity of radiotracer uptake in tumors. Previous studies suggested that measurements of (18)F-FDG accumulation in tissue might be affected by the image reconstruction method, but the clinical relevance of these findings has not been assessed.

Methods: Phantom studies were performed and clinical whole-body (18)F-FDG PET images of 85 cancer patients were analyzed.

Head and neck cancer: clinical usefulness and accuracy of PET/CT image fusion.

Purpose: To compare diagnostic accuracy of attenuation-corrected positron emission tomography (PET) with fused PET and computed tomography (CT) in patients with head and neck cancer and to evaluate the effect of PET/CT findings on patient care.

Materials And Methods: Studies of 68 patients were reviewed by two physicians in consensus. Focal fluorodeoxyglucose (FDG) uptake in the head and neck on attenuation-corrected PET images was graded as benign, equivocal, or malignant.

PET/CT in oncology: integration into clinical management of lymphoma, melanoma, and gastrointestinal malignancies.

PET/CT is a new imaging technology that has already found a number of clinical applications in oncologic imaging. Widespread introduction into clinical practice started approximately 2.5 years ago.

Patterns of (18)F-FDG uptake in adipose tissue and muscle: a potential source of false-positives for PET.

Unlabelled: The routine use of PET/CT fusion imaging in a large oncology practice has led to the realization that (18)F-FDG uptake into normal fat and muscle can be a common source of potentially misleading false-positive PET imaging in the neck, thorax, and abdomen. The goal of this study was to characterize this normal variant of (18)F-FDG uptake in terms of incidence and characteristic extent.

Methods: All body scans done on our PET/CT scanners in July and August 2002 were retrospectively reviewed.

Respiratory artefact causing malpositioning of liver dome lesion in right lower lung.

The new combined positron emission (PET)/computed tomographic (CT) scanners have many advantages over PET scanners alone. However, physicians must be aware of the potential artefacts observed in PET/CT scanners. A body PET/CT was performed on an 81-year-old man with colorectal cancer.

FDG-PET in Esophageal Cancer. Incremental Value over Computed Tomography.

OBJECTIVES: To evaluate the clinical utility of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in patients with cancer (CA) of the esophagus, and its incremental value over computed tomography (CT) scan.METHODS: Positron emission tomography (PET) scan and CT scan reports of all patients with biopsy-proven CA esophagus from December 1995 to August 1998 were reviewed. PET images were acquired on a high-resolution dedicated PET scanner 45 minutes to 1 hour after intravenous injection of 370 MBq of fluorine-18-fluorodeoxyglucose (F-18-FDG).

Defining the Role of FDG PET in Head and Neck Cancer.

The purpose of this article is to elucidate the role of 2-[18F] Fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) in evaluating patients with head and neck cancer. This will include background information on patient preparation and image acquisition. Normal patterns of uptake will be described in reference to computerized tomography (CT)/magnetic resonance imaging (MRI) to illustrate the relationship of physiology to the anatomic landmarks.

Differential Metabolism and Pharmacokinetics of L-[1-(11)C]-Methionine and 2-[(18)F] Fluoro-2-deoxy-D-glucose (FDG) in Androgen Independent Prostate Cancer.

Metabolic imaging with positron emission tomography (PET) for the staging and monitoring of treatment response has important implications in clinical oncology. The choice of radiotracer is likely to be critically important. The objective of our study was to compare the pharmacokinetics of C-11-methionine with FDG in a group of androgen independent patients with metastatic prostate cancer, to determine the differential metabolism of the two tracers, and to determine the optimal time of imaging after injection in treated and untreated patients.

Tumor Treatment Response Based on Visual and Quantitative Changes in Global Tumor Glycolysis Using PET-FDG Imaging. The Visual Response Score and the Change in Total Lesion Glycolysis.

"Functional" tumor treatment response parameters have been developed to measure treatment induced biochemical changes in the entire tumor mass, using positron emission tomography (PET) and [F-18] fludeoxyglucose (FDG). These new parameters are intended to measure global changes in tumor glycolysis. The response parameters are determined by comparing the pre- and posttreatment PET-FDG images either visually from the change in image appearance in the region of the tumor, or quantitatively based on features of the calibrated digital PET image.

PET/CT: a new imaging technology in nuclear medicine.

This review discusses the technical background of combined PET and CT and considers the clinical applications of PET/CT imaging. Questions addressed include: Is PET/CT superior to PET imaging alone? If so, in which patient populations and in what respect? Can PET/CT imaging affect patient management? Can PET/CT be practiced economically? While much work remains to be done, the available data clearly suggest that PET/CT decreases imaging time per patient and, even for the experienced reader, significantly reduces the number of equivocal PET interpretations. PET/CT also has the ability to improve accuracy of PET image interpretation and to affect clinical decision making, thereby improving patient management.

Combined 18F-FDG and 11C-methionine PET scans in patients with newly progressive metastatic prostate cancer.

Unlabelled: Metastatic prostate cancer may respond initially to hormone suppression, with involution of tumor sites, but ultimate tumor progression is inevitable. Our aim was to detect the proportion of bone and soft-tissue lesions that represent metabolically active tumor sites in patients with progressive metastatic prostate cancer.

Methods: In a prospective study, we compared 18F-FDG and L-methyl-11C-methionine (11C-methionine) PET with conventional imaging modalities (CIM), which included the combination of 99mTc-methylene diphosphonate scintigraphy, CT, or MRI.