Publications by authors named "Henry U Arnold"
Article Synopsis
- This study presents a cancer phenotyping method using targeted sequencing of cell-free DNA (cfDNA) specifically for small cell lung cancer (SCLC).
- The researchers developed a targeted capture panel that analyzes transcription factor (TF) binding sites and gene transcription start sites, successfully detecting mutations and TF activity in SCLC samples.
- The prediction models for specific TF activities demonstrated high accuracy, with potential for distinguishing different lung cancer types and monitoring tumor transformations, indicating broader applications for other cancer types.
Purpose: The addition of immune checkpoint blockade (ICB) to platinum/etoposide chemotherapy changed the standard of care for small cell lung cancer (SCLC) treatment. However, ICB addition only modestly improved clinical outcomes, likely reflecting the high prevalence of an immunologically "cold" tumor microenvironment in SCLC, despite high mutational burden. Nevertheless, some patients clearly benefit from ICB and recent reports have associated clinical responses to ICB in SCLC with (i) decreased neuroendocrine characteristics and (ii) activation of NOTCH signaling.
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