Publications by authors named "Henry T P Annecke"
J Biomol NMR
December 2024
Article Synopsis
- Understanding nucleic acids' structure and function in their natural cellular environment is essential for structural biology, with in-cell NMR spectroscopy being a key method used to achieve this.
- Challenges such as sample decay, low signal intensities, and RNA degradation hinder the effectiveness of in-cell NMR in human cell lines, limiting the structural information obtainable.
- The study optimizes the detection of imino proton signals in HeLa cells using selective excitation, improving measurement speed and signal quality, and providing insights into the dynamics and structure of nucleic acids within cells.
