Publications by authors named "Henry Richard Johnston"
Article Synopsis
- * Researchers developed an experimental system to screen for signaling pathways during early 3D invasion in lung adenocarcinoma, revealing that loss of LKB1 enhances BMP6 signaling, which influences iron regulation and tumor growth.
- * In pre-clinical models, targeting the ALK2/BMP6 signaling pathway showed significant anti-tumor effects, and elevated BMP6 levels were found in lung cancer patients with LKB1 mutations, suggesting a potential treatment approach for these patients.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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- Asthma affects people differently depending on their race, and there haven't been enough studies on people of African ancestry.
- A new study looked at data from 7,009 people with asthma and 7,645 without, and found strong links to four previously known gene areas.
- The study also discovered two new gene areas that might be especially important for asthma risk in people of African ancestry.
A primary goal of The Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) is to develop an 'African Diaspora Power Chip' (ADPC), a genotyping array consisting of tagging SNPs, useful in comprehensively identifying African specific genetic variation. This array is designed based on the novel variation identified in 642 CAAPA samples of African ancestry with high coverage whole genome sequence data (~30× depth). This novel variation extends the pattern of variation catalogued in the 1000 Genomes and Exome Sequencing Projects to a spectrum of populations representing the wide range of West African genomic diversity.
View Article and Find Full Text PDFThe African Diaspora in the Western Hemisphere represents one of the largest forced migrations in history and had a profound impact on genetic diversity in modern populations. To date, the fine-scale population structure of descendants of the African Diaspora remains largely uncharacterized. Here we present genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas.
View Article and Find Full Text PDFGeneticists have, for years, understood the nature of genome-wide association studies using common genomic variants. Recently, however, focus has shifted to the analysis of rare variants. This presents potential problems for researchers, as rare variants do not always behave in the same way common variants do, sometimes rendering decades of solid intuition moot.
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