Sneaky Sarcoidosis or a Metastatic Masquerade? - A case of nodular sarcoidosis.

Sarcoidosis is a multisystem disease of unclear pathogenesis that peaks between ages 20 to 39. Sarcoidosis is more common in women and affects blacks three times more frequently than whites. Nodular sarcoidosis is a rare variant of sarcoid that occurs in 1-4 percent of patients.

Hepatocellular carcinoma xenograft supports HCV replication: a mouse model for evaluating antivirals.

Aim: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.

Methods: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice.